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L Farwell

Publications and source records attributed to L Farwell.

4 recordsLinked to original sources
PubMed2006

The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.

To date, three loci have been validated to confer susceptibility to inflammatory bowel disease (IBD): the CARD15/NOD2 gene, the discs large homolog 5 gene (DLG5), and the IBD5 locus on 5q31 (IBD5). We have explored the possibility that these loci may also be associated with susceptibility to two other chronic inflammatory diseases, multiple sclerosis (MS) and systemic lupus erythematosus (SLE). As the CARD15 risk alleles had previously been assessed in our collection of 496 MS trios, we focused our efforts on the DLG5 risk allele and the IBD5(risk) haplotype (IBD5(risk)) for MS. While there is no evidence of association within our MS sample with either of these polymorphisms, screening of 1027 subjects with SLE suggests that IBD5(risk) may have a modest contribution to disease risk in the subset of SLE subjects without lupus nephritis. In addition, a pooled analysis of existing published and unpublished data in 1305 cases of SLE genotyped for the CARD15 risk alleles suggests that only the CARD15(908R) IBD risk allele may have a strong effect on risk of SLE. Our data, therefore, suggest that both the CARD15 gene and the IBD5 locus may have a role as general susceptibility loci for certain common, genetically complex inflammatory diseases.

Chromosomes, Human, Pair 5↗
PubMed1998

Narcissistic processes: optimistic expectations, favorable self-evaluations, and self-enhancing attributions.

Three studies investigated the relationship between narcissism (as measured by the Narcissistic Personality Inventory; Raskin & Hall, 1979) and three forms of self-enhancement. In Study 1, narcissism positively correlated with predictions of own final course grades, but not with actual grades received. In Study 2, narcissism positively correlated with estimated current course grades; high narcissists tended to overestimate their grades, while low narcissists tended to underestimate them. In Study 3, narcissism was associated with optimistic expectations for own performance on a laboratory interdependence task and with attributions of a successful task outcome to own ability and effort, but it did not correlate with attributions to a partner's ability or effort, suggesting self-aggrandizement but not other-derogation. Narcissism was also associated with weaker gratitude and liking. Results are discussed in terms of their implications for the origins and generality of self-enhancement and for the relationship between narcissism and self-functioning in the social domain.

Female↗