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Biomedical subjects

L Fattore

Publications and source records attributed to L Fattore.

At least 37 records · Page 2Linked to original sources
PubMed1997

Rewarding properties of gamma-hydroxybutyric acid: an evaluation through place preference paradigm.

Gamma-hydroxybutyric acid (GHB), a putative neurotransmitter or neuromodulator found in the mammalian brain, has been successfully used in clinical practice to alleviate both alcohol and opiate withdrawal symptoms. In the present study we used a conditioned place preference (CPP) paradigm to investigate whether GHB possesses rewarding properties in rats. In order to exclude possible artifacts due to experimental design, we evaluated the possibility of a shift in preference when rats are conditioned either on their non-preferred side or on a randomly assigned side of conditioning. In both experiments GHB was seen to induce CPP. Although to date the physiological role of this compound still remains unclear, there is no doubt that GHB, further to its proven effect on alcohol and opiates, possesses rewarding properties of its own. The abuse liability afforded by this drug suggests the use of particular caution in handling GHB as a clinically useful drug.

Animals↗
PubMed1993

Osteoporosis and osseointegration of implants.

According to medical literature, osteoporosis and related bone pathologies are increasing in epidemic proportions. The exact etiology of the disease is unknown, but hormonal, dietary, and genetic factors all contribute to the related loss of bone density. In the disease process, bone loss occurs throughout the body. Research indicates that the mandible and maxilla are affected, and show oral manifestations. There is no scientific data to contraindicate the use of two-step osseointegrated implants in osteoporotic individuals. The purpose of this article is to review the literature regarding osteoporosis and its relationship to oral bone loss.

Alveolar Bone Loss↗
PubMed1991

Use of an implant in repair of a fixed partial denture. A clinical report.

A repair technique for a fractured solder joint in a multiple-unit fixed partial denture has been presented. The advantages of this technique include (1) retention of part of an existing restoration; (2) provision of additional support to minimize future fracture; (3) removal of the implant crown for periodic evaluation and/or treatment; and (4) retention of a fixed partial denture where a removable prosthesis might otherwise be needed. The primary disadvantage of this technique is the time and expense associated with implant placement.

Adult↗
PubMed1989

The association of mucocutaneous lichen planus and chronic liver disease.

A possible association between mucocutaneous lichen planus and chronic liver disease has been previously postulated in the medical literature. Despite the frequency with which lichen planus occurs in the oral cavity, little mention of such a relationship has been made in the dental literature. A case of lichen planus occurring in a patient with primary biliary cirrhosis and a review of the subject are therefore presented.

Aged↗
PubMed1988

Use of a two-piece Gunning splint as a mandibular guide appliance for a patient treated for ameloblastoma.

Prosthodontic restoration in edentulous patients who have undergone hemisection of the mandible is difficult because of the instability of the mandible after resection and the lack of teeth necessary for successful retention of a guidance appliance. Successful prosthodontic restoration was accomplished through the use of a two-piece Gunning splint both for intermaxillary fixation and as a guidance appliance in an edentulous patient who underwent a hemisection of the mandible subsequent to treatment for an ameloblastoma. Because mandibular guidance therapy is most successful in patients whose resection involves only bony structures with minimal loss of soft tissue and no radical neck dissection or radiation therapy, the patient treated for ameloblastoma is an ideal candidate for the use of a two-piece Gunning splint for intermaxillary fixation and mandibular guidance therapy.

Ameloblastoma↗
PubMed1987

A technique for fabrication of a cheek recontouring prosthesis.

A technique has been described for fabrication of a removable prosthesis that restores proper cheek contour. This prosthesis is a modified removable partial denture with a retentive surface to hold an acrylic resin bolus to recontour the cheek from within. The advantages of such a prosthesis for the patient with facial nerve paralysis include restoration of fullness and proper contour to the cheek (Figs. 7 and 8), prevention of trauma to the buccal mucosa during mastication, and stretching of the cheek, which indirectly improves oral hygiene in the buccal sulcus. The disadvantages of this technique include limited improvement in esthetic and functional contour of the cheek, and food accumulation beneath the acrylic resin bolus, which requires more meticulous hygiene.

Acrylic Resins↗
PubMed1987

Radiation carrier for treatment of nasopharyngeal carcinomas.

A technique for intracavitary radiation therapy of nasopharyngeal carcinomas has been presented. This technique includes a direct impression technique of the nasopharynx and fabrication of a silicone carrier to house the radioactive source.

Brachytherapy↗
PubMed1987

Hyperbaric oxygen in the treatment of osteoradionecrosis: a review of its use and efficacy.

Hyperbaric oxygen (HBO) therapy is an established technology that is proving to be effective in the treatment of osteoradionecrosis. However, the studies that have shown this treatment modality to be effective have not established the optimum pressures, times of exposure, and frequency and number of treatment necessary for healing. In addition, most of the studies used HBO as an adjunctive treatment in the management of refractory osteoradionecrosis. The efficacy of HBO as a primary treatment modality has not as yet been established. Strictly controlled clinical trials are necessary for identification of patients who are likely to respond to HBO without aggressive surgery, to delineate a timetable for treatment of patients with HBO, and to coordinate surgery with HBO to resolve osteoradionecrosis when a significant amount of bone loss is involved.

Humans↗
PubMed1984

Clinical evaluation of the accuracy of interocclusal recording materials.

The importance of accurate, reliable recording mediums cannot be understated. Function and esthetics are directly related to this critical step. Dental recording materials must be accurate, easily manipulated, and economical for effective use. Five types of intraoral records of 31 patients were registered and placed on an arcon, semiadjustable articulator to measure the magnitude and direction of distortion. The results were the following. Polyether interocclusal recording medium without a carrier was the most accurate. Polyether and zinc oxide-eugenol pastes with carriers were the next most accurate recording mediums, but they required a disciplined technique. Recording waxes were consistently unreliable. Distortion occurred more frequently in a vertical direction, followed by an anteroposterior direction.

Clinical Trials as Topic↗
PubMed1984

Simplified method for fabricating a prong denture for atrophic maxillae.

A simpler technique for fabricating a prong denture has been described. The prong denture was placed in the mouth of a patient with an atrophic maxilla, who was suffering from ALS, a disabling motor disease. The patient was unable to manage a conventional denture. With the insertion of a prong denture, the patient experienced greatly increased retention and function of his maxillary prosthesis and a more favorable attitude toward himself and his disease.

Atrophy↗
PubMedDate not supplied

Gingival hyperplasia: a side effect of nifedipine and diltiazem.

Currently, calcium channel blockers are being used increasingly for the treatment of hypertension in the elderly. Several case reports in the dental literature suggest that patients treated with the calcium channel blockers manifest gingival hyperplasia similar to that seen in patients taking phenytoin (Dilantin, Parke-Davis). A small study of 89 patients undertaken at the Westside Veterans Administration Medical Center, Chicago seems to indicate that nifedipine and diltiazem do indeed cause gingival hyperplasia. A total of 83% of the patients studied receiving nifedipine showed evidence of hyperplastic tissue and 74% of those on diltiazem were found to have hyperplastic tissue.

Aged↗