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Biomedical subjects

L Ferrante

Publications and source records attributed to L Ferrante.

At least 91 records · Page 5Linked to original sources
PubMed1988

Pharmacokinetics of teicoplanin.

We investigated the pharmacokinetic properties of teicoplanin, after 200 mg i.v. and i.m. administration in 10 healthy male subjects by assuming a three-compartment open model with elimination from the central compartment. The mean peak plasma level was 7.16 micrograms/ml reached after 2.26 h. The half-life, the plasma and renal clearances, evaluated from i.v. data were 44.49 h, 15.31 and 9.08 ml/min, respectively. The same parameters after i.m. administration were 45.62 h, 15.31 and 9.46 ml/min. The estimates of creatinine clearance (Clcr greater than 80 ml/min), renal clearance and the low free fraction (fB approximately equal to 0.1) suggested a tubular reabsorption, FR, of the drug. The distribution volume at steady state after i.v. and i.m. administration (Vss = 41.29 and 44.76 litres) were nearly total body water. Bioavailability of the drug (F = 92.4%) showed an almost completely absorption of teicoplanin after i.m. administration. Urinary recovery was 49.6 and 47.9% of the dose after i.v. and i.m. administration, respectively.

Adult↗
PubMed1988

Tension pneumocephalus after CSF shunting procedures.

We report a case of tension pneumocephalus following the insertion of a ventriculoperitoneal shunt for hydrocephalus secondary to aqueduct stenosis and discuss the possible genesis of the complication, diagnosis and treatment.

Cerebrospinal Fluid Shunts↗
PubMed1988

Tuberculoma of the ulnar nerve: case report.

A peripheral nerve tuberculoma, the third on record, involved the ulnar nerve, as did the other two. This case report is followed by a discussion of the pathogenesis and diagnosis of this lesion. Its pathogenesis is unclear. Direct infection from a tuberculous sister was disproved, and infection via a local wound is highly unlikely. A previous, silent form of tuberculosis seems to have been the cause.

Adult↗
PubMed1988

Supratentorial hemangioblastoma. Report of a case and review of the literature.

Hemangioblastoma is a benign tumor of vascular origin that develops usually in the posterior cranial fossa and only very rarely in the supratentorial region. A case of supratentorial hemangioblastoma is reported and the 71 published cases are reviewed. The features that distinguish this tumor from angioblastic meningioma are discussed, the clinical and biological features of supratentorial and subtentorial hemangioblastoma are compared, the neuroradiological findings examined and the results of treatment assessed.

Adult↗
PubMed1987

Association between intracranial aneurysms and pituitary adenomas. AEtiopathogenetic hypotheses.

Of 144 cases of pituitary adenoma operated on in the period 1981-1985, 53 underwent angiography and two of these had an associated intracranial aneurysm. The aetiological hypotheses are viewed in the light of these two cases and of the 60 published cases of this association. The most convincing hypotheses involve mechanical, microcirculatory and hormonal factors. On the hormonal front, GH seems to have a predisposing influence on intracranial aneurysm formation.

Adenoma, Acidophil↗
PubMed1987

Intrasellar tuberculoma: case report.

We report a unique case of exclusively intrasellar tuberculoma. The patient was operated on by the transsphenoidal approach, which allowed total removal of the lesion and prevented cerebrospinal fluid contamination. After histological diagnosis, the patient was treated with isoniazid, 300 mg daily for 3 months, as prophylaxis against tuberculous meningitis.

Female↗
PubMed1987

Sulbenicillin: pharmacokinetics and penetration into bronchial secretion in elderly patients.

This study evaluates the pharmacokinetics of sulbenicillin (alpha-sulfobenzylpenicillin) in elderly subjects after single and multiple doses and the penetration into bronchial secretion in elderly patients with chronically superinfected bronchial pathology. Peak plasma levels were 53.34 micrograms/ml (group I); 55.80 and 57.82 micrograms/ml (group II) after 1 h. The half-life (t 1/2 beta) was 1.47 h (group I); 1.49 and 1.62 h (group II). Renal clearance was 6.68 l/h; 6.25 and 5.44 l/h; whereas the volume of distribution was 18.02 l; 17.84 and 17.21 l for groups I and II respectively. The mean percentage of the recovered active drug in urine over 12 h was 77.72% of dose. The mean peak reaching the bronchial secretion was 3.60 micrograms/ml at the 4th hour. The results of the multiple dose study indicated that there was no apparent change in the distribution or elimination kinetics of sulbenicillin after 2 g i.m. administration. Thus, the kinetics from the multiple dose study were in close agreement with those from the single dose study and no accumulation of sulbenicillin was observed. This study provided satisfactory results and confirmed the significant presence of sulbenicillin into bronchial secretions.

Absorption↗
PubMed1986

Discontinuous oral absorption of cimetropium bromide, a new antispasmodic drug.

The pharmacokinetic profiles of cimetropium bromide, after either intravenous injection of 10 mg or oral ingestion of 200 mg, were determined in eight healthy volunteers. After intravenous administration, the plasma levels and urinary excretion indicated that the drug is distributed and eliminated at a rapid rate (terminal half-life, 50 +/- 8 min) and that urinary excretion is not the exclusive route of elimination (46 +/- 2%) of the administered dose). After oral administration, a low percentage of the drug is absorbed (1-4% of the administered dose), however, the amount is sufficient for therapeutic effect. The absorption is discontinuous, with two distinct phases, and ends abruptly during the second phase.

Administration, Oral↗
PubMed1986

Subarachnoid haemorrhage of unknown origin.

This study concerns 64 patients with angiographically negative subarachnoid haemorrhage (SAH) hospitalized in the period 1970-1982. Requisites for inclusion in the study were adequate angiographic demonstration of the carotid and vertebrobasilar systems and no clinical signs of spinal SAH or spontaneous intracerebral haematoma. The clinical data on the 64 cases confirm the close similarity, except for the prognostic factors, between angiographically negative SAH and SAH secondary to rupture of an intracranial saccular aneurysm. The study underlines the benign character of the clinical course and of the medium and long-term prognosis of the condition under study. In view of this, the hypothesis advanced sometime ago relating angiographically negative SAH to the rupture of microaneurysms (phi less than 2 mm) of the large cerebral arteries with subsequent complete repair of the artery wall, or to the spontaneous thrombosis of intracranial saccular aneurysms, with the possibility of subsequent recanalization and risk of fresh rupture, would appear to be a reasonable one.

Brain Neoplasms↗
PubMed1985

Cysticercosis cerebri. Report on seven cases.

The authors report the clinical features, diagnosis and treatment of seven personal cases of cerebral cysticercosis. The epidemiology, anatomical location and therapeutic possibilities are studied. A brief review of the literature of 814 cases of neurocysticercosis is also reported.

Adult↗
PubMed1984

Haemangioblastomas of the posterior cranial fossa.

The clinical features, diagnostic and surgical aspects of haemangioblastoma of the posterior cranial fossa are discussed in the light of a series of 61 personal cases and the published data. CT and vertebral angiography are compared as diagnostic tools. With the aid of microsurgery even haemangioblastomas of the brainstem and fourth ventricle can be removed successfully.

Adolescent↗
PubMed1984

Cerebral arteriovenous malformations in children. Clinical features and outcome of treatment in children and in adults.

A study of 19 children with cerebral arteriovenous malformation (AVM) is reported; these children represent 12% of 161 patients with this disease at the Rome University Institute of Neurosurgery. The published data on intracranial arteriovenous malformations in children and in adults are reviewed and the clinical features and results of treatment in the two age groups compared. The results of surgical removal seem to be better in children while the follow-up mortality with conservative treatment is higher. The last point receives indirect confirmation from a study of the risk of bleeding in which the patients of our series were compared by age at clinical onset, viz. those under 15 years of age and those over 15 years. After an average follow-up of slightly over 10 years, the risk of bleeding is higher with onset before the age 15 years and significantly higher if the onset is nonhemorrhagic.

Adolescent↗