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Biomedical subjects

L Filippini

Publications and source records attributed to L Filippini.

At least 19 recordsLinked to original sources
PubMed1992

[Intramural rupture and intramural hematoma of the esophagus: 3 case reports and literature review].

Together with three of our own observations of intramural rupture (IRO) or hematoma (IHO) of the esophagus, we have analyzed 91 case reports from the literature. Precipitating factors were identified in 63% of all patients. Most frequently potentially traumatic events such as vomiting (22%) or instrumentation (17%) preceded IRO/IHO. In 21% there were disturbances of hemostasis, either alone (15%) or in addition to a traumatic event (6%). 37% of IRO/IHO were spontaneous. In 35% the typical clinical triad of acute retrosternal pain, odynophagia or dysphagia and hematemesis was complete; in 46% only two out of three symptoms were present. IRO/IHO was managed conservatively in 84% of the patients, whereas 9% required surgery for complications. 7% were operated on without a precise indication. One patient died following surgery for endoscopic perforation. The rare syndrome of IRO/IHO must be considered in patients with acute retrosternal pain. Treatment is primarily conservative and the prognosis is excellent.

Aged↗
PubMed1978

[Endobrachyesophagus (Barrett's syndrome)--a not sufficiently familiar disease pattern (author's transl)].

The clinical picture of endobrachyesophagus (Barrett's Syndrome) which is little known among radiologists, is described, taking the authors' own observations into account. As soon as the complications leading to clinically manifest complaints occur, consisting of high or centrally positioned peptic stenosis and/or ulceration, diagnosis can be established by means of the usually characteristic findings when a barium sulfate contrast medium is made to pass through the esophagus. Endoscopic-bioptic exploration of the esophagus is mandatory to verify the diagnosis, and, in particular, to exclude any malignant process, the more so since malignant degeneration of cylindrical cell metaplasia, on which endobrachesophagus is based, must be reckoned with in up to 10% of the cases.

Esophageal Stenosis↗
PubMed1977

[Prognosis of acute upper gastrointestinal bleeding before and after the introduction of emergency endoscopy (author's transl)].

A total of 416 patients had been admitted to hospital for acute upper gastrointestinal bleeding, about half of them before the introduction of endoscopy. There was a highly significant decrease in total mortality rate by 18 percent since the introduction of endoscopy. The reason for this is probably largely the much higher number of correct identification or localisation of bleeding points by endoscopy (98 percent) when compared with conventional radiological examination.

Adult↗
PubMed1977

[Alcohol-induced hyperlipoproteinemia].

Tests on 100 alcoholic patients revealed increased lipoprotein levels in 24%. Type IV was the most frequently ecountered (80%), followed by type II or V. The average plasma triglyceride level of the alcoholic group was significantly increased in comparison with a control population. The causal mechanism of alcoholic hyperlipoproteinemia remains poorly understood. The combination of a genetic defect of lipid metabolism, nutritional factors and acute alcohol excess may have an essential bearing on the incidence of hyperlipoproteinemia. Acute excessive intake of alcohol was significantly increased in comparison with alcoholic subjects wihtout hyperlipoproteinemia. The critical dose may be a daily ethanol consumption of about 200 gm. There appeared to be no correlation between acute pancreatic injury or active liver disease and serum lipid elevation. On the other hand, the observation was confirmed that alcoholic patients with hepatic cirrhosis usually do not develop hyperlipoproteinemia. Ethanol-induced hyperlipoproteinemia may be a risk factor for the development of atherosclerosis and pancreatitis.

Adult↗
PubMed1977

[Diverticular disease of the colon (author's transl)].

Admission diagnosis of 100 patients with diverticular disease of the colon indicated that the clinical features of the disease is still relatively unknown. The most important cardinal symptoms are abdominal complaints, irregular stools and/or bleeding from the large intestine. These symptoms occur with about equql frequency in patients with diverticular disease, whether or not there was evidence of inflammatory complications. If there is clinically manifest diverticulum formation of the colon, the term "diverticular disease" seems appropriate, since transition between diverticulosis and diverticulitis is fluid. In addition to bleeding and attacks of diverticulitis, fistulae and gut narrowing with or without ileus are other complications. Mechanical small-intestinal ileus with involvement of the small intestine in the inflammatory diverticulitis mass was a feature of several of the authors' cases. Low-residue diet is contra-indicated because such food probably plays an important part in the aetiology and pathogenesis of diverticular disease.

Adult↗