Thin-layer chromatography of metallic derivatives of ethylenebis(dithiocarbamic acid) and their degradation products.
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Biomedical subjects
Publications and source records attributed to L Fishbein.
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Selenium occupies a unique position in regards to continuing conflicting aspects of its toxicological and nutritional significance. This review focuses on the environmental sources and sinks, transport and alterations of selenium. Both natural and anthropogenic sources of selenium are considered with primary emphasis on the occurrence and significance of selenium in soils, air, water, plants and foods. The patterns and trends of application of selenium are also highlighted in order to focus on the the potential populations at risk.
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This review summarizes salient features of the recently completed large-scale, long-term animal carcinogenicity study conducted at the National Center for Toxicological Research.
A variety of alkylating agents, acylating agents, peroxides, halogenated derivatives, and nitrogen derivatives have been reviewed, principally in terms of their synthesis, areas of utility, stability, distribution, reactivity, levels of exposure, population at risk, metabolism, carcinogenicity, and mutagenicity.
Use of animal data to estimate the human risk from long-term exposure to low doses of environmental carcinogens poses a number of biological, toxicological, and statistical problems. One of the problems is that of extrapolating animal dose-response relations from the high-dose range, where animal test data are available, to the low doses that humans might encounter. Different mathematical models for extrapolation are summarized, and the procedures for an problems of estimating human risk on the basis of animal studies are evaluated.
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