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5-Fluorouracil and recombinant interferon alfa-2a: review of activity and toxicity in advanced colorectal carcinomas.

Improved response rates in metastatic colorectal carcinoma recently have been observed for the combination of 5-fluorouracil (5-FU) and recombinant interferon alfa-2a (rIFN), compared to those obtained in historical trials of single-agent 5-FU. The mechanism of interaction between these agents has not been explored adequately but may relate to biochemical modulation of 5-FU by rIFN. Toxicities resulting from this combination have included fever, chills, myalgias, granulocytopenia, mucositis, diarrhea, skin rash, neurological symptoms, and hand-foot syndrome. Future studies of 5-FU with rIFN should investigate schedules aimed at reducing toxicity without compromising efficacy and also should explore mechanisms of enhanced activity.

Aged↗

PubMedDate not supplied

[IgG antibodies against Toxoplasma gondii in Cuban blood donors].

Sera from 1036 donors at the Hemotherapy Service of the General Hospital "Luis Díaz Soto" were evaluated for IgG anti-Toxoplasma gondii antibodies. No significant difference was found among sexes. The presence of T. gondii antibodies were distributed in eight age categories; a minor and a major presence of specific IgG for the young and old age groups, respectively was found. The relationship of specific antibodies and ABO blood groups were considered for the masculine gender. The AB blood group a significant difference (P < 0.05), except for the B blood group in the rate of T. gondii antibodies.

ABO Blood-Group System↗