Topiramate for binge-eating disorder.
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Biomedical subjects
Publications and source records attributed to L Fontenelle.
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Set-shifting ability and therapeutic response to serotonin reuptake inhibitors were investigated in 20 patients with obsessive-compulsive disorder. A clear relationship was found between impaired performance on two Wisconsin Card Sorting subtests (categories completed and perseverative errors) and positive treatment response.
OBJECTIVE: To provide pediatricians with updated information about the neurological problems that most frequently affect adolescents, allowing doctors to diagnose, investigate and treat migraine headaches and seizures, and other conditions. METHODS: Non-systematic review of medical literature combined with clinical experience acquired at the Martagão Gesteira Institute of Child Care and Pediatrics, Universidade Federal do Rio de Janeiro. RESULTS: Neurological conditions account for an increased frequency of medical appointments among adolescents. A significant number of these patients have seizures, and behavioral and learning disorders. CONCLUSIONS: Most cases can be assessed by non-specialists. This articles aims at supplying pediatricians with tools that will help them diagnose and treat a great number of the situations.
In the last few years we have been able to diagnose a larger number of cases of Moebius syndrome, perhaps due to its increased incidence--since a number of environmental factors have been related to the genesis of the syndrome. Out of the cases evaluated in two specialized ambulatory, it is worthwhile to mention one of them due to an uncommon association with cortical heterotopy, among others malformations.
Kleine-Levin syndrome is characterized by periodic hypersomnia, hyperphagia, sexual disinhibitions and behavioral disturbances. The prognosis is generally benign, with normal cognitive and social functions after the episodes. We describe a typical case of Kleine-Levin syndrome associated with apparent academic decline, neuropsychological sequelae and personality alterations after the second episode of the illness. Further research in the natural history of Kleine-Levin syndrome is needed, for example, to determine whether early intervention would improve long-term prognosis.
The predictive value of quantitative electroencephalography (EEGq) was investigated with regard to the pharmacological treatment of 10 non-medicated obsessive-compulsive disorder (OCD) patients diagnosed according to DSM-IV criteria. The following variables were selected: bipolar relative power in alpha band for Cz-C3, Cz-C4, T3-T5, T4-T6, T3-F7 and T4-F8; bipolar relative power in theta band for Cz-C3, Cz-C4, T3-T5, T4-T6, T3-F7 and T4-F8; and monopolar relative power in theta band for Fp1, Fp2, F7, F3, Fz, F4 and F8. There was statistically significant deviations in five patients with regard to bipolar relative power in alpha band for central regions when compared to normative data bank (control group). This group of patients had a significantly lower age of OCD onset and worse response to pharmacotherapy with serotonin reuptake inhibitors.
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The study of epileptic syndromes in children displaying a poor prognosis reveals common characteristics which allow the delineation of a clinical profile. In this study, hospital records of a treatment of convulsions in children were analysed during a two year period. We observed that the majority of cases presented this clinical profile.
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