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Biomedical subjects

L Fonzi

Publications and source records attributed to L Fonzi.

At least 37 records · Page 2Linked to original sources
PubMed1982

Response of lung enzyme activities in rabbits following short-term exposure to n-hexane: correlation between morphological and biochemical changes.

The activity of lactate dehydrogenase, beta-glucuronidase, glucose-6-phosphate dehydrogenase, acid and alkaline phosphatase was studied in lung homogenate from New Zealand rabbits exposed to 3000 p.p.m. of n-hexane 8 h per day for 8 days of filtered air. In hydrocarbon-treated animals all enzymes examined, except alkaline phosphatase, were markedly increased. The biochemical changes correlated well with the morphological changes and the results of cytological evaluation of bronchopulmonary lavage. It is suggested that high values in lung lysosomal enzymes from treated rabbits reflect the acute inflammation whilst the increase in lung glucose-6-phosphate dehydrogenase may depend upon reparative process subsequent to n-hexane-induced lung damage.

Alkaline Phosphatase↗
PubMed1982

Ultrastructural observations on morphogenesis of atypical cilia.

Though ultrastructural studies of bronchial epithelium both in man and in experimental animals revealed in a variety of conditions the presence of pathologically altered cilia, little is known about their genesis and significance. In this work we have described the alterations noticed in ciliary morphology during the formation of atypical cilia. A probable mechanism for their production is also proposed on the basis of our results.

Animals↗
PubMed1980

[A rare case of continuous type spleno-gonadal fusion].

The authors present a case of continuous spleno-testicular fusion in a three year old child and emphasize the rarity of this condition, on the basis of an examination of the literature. The pathogenic mechanisms and clinical characteristics of this condition are studied in the light of the reported cases, and are discussed.

Adolescent↗
PubMed1980

Respiratory tract lesions induced in rabbits by short-term exposure to N-hexane.

New Zealand rabbits were exposed in inhalation chambers to 3,000 ppm of n-hexane 8h/d for 8 d, and the acute respiratory effects were studied by light and electron microscopy. Animals intoxicated showed morphological changes in the lung parenchyma characterized by centriacinar emphysema and scattered micro haemorrhages. Lung damage was most severe at the transition zone from terminal bronchiole to alveolar ducts. This centriacinar lesion consisted to degenerative and necrotic phenomena in bronchiolar epithelium with cellular desquamation, increased number of macrophages within proximal alveoli of alveolar ducts, increased number and size of lamellar bodies in alveolar type II cells, changes in the vascular endothelium. Focal subpleural atelectasis, alveolar and interstitial oedema were also found. The segmental distribution of the pulmonary lesions were confirmed by transmission electron microscopy.

Animals↗
PubMed1979

[Pulmonary damage in the rabbit caused by porcine pancreatic elastase and leukocyte lysate: unusual microscopic aspects].

Intratracheal injection of rabbit whole leukocyte homogenate induced emphysema-like lesions in rabbits. The lesions were produced only by preparations having elastinolytic activity. The pathological aspects appeared similar to those induced by the administration of porcine pancreatic elastase. The pulmonary changes, resembling several of the anatomic appearances of panacinar human emphysema, may be a suitable experimental model for studying histogenesis of panacinar human emphysema. Numerous abnormal fenestrations were present in air spaces walls and were a constant feature in opposition to that has been reported in elastase-treated hamsters. For the presence of a prominent dilatation of the periarterial lymphatic network, this experimental model might be used also for studying the ultrastructural features of pulmonary lymphatic vessels.

Animals↗
PubMedDate not supplied

Ultrastructural abnormalities in respiratory cilia and sperm tails in a patient with Kartagener's syndrome.

Ultrastructural abnormalities of spermatozoa and respiratory cilia have been reported in a male patient with Kartagener's syndrome and infertility. In this patient both respiratory cilia and sperm tails showed defects in radial spokes and dynein arms. Such defects are heretofore undescribed in the same subject with immotile cilia syndrome. Absence of both inner and outer dynein arms and absence of the inner dynein arms only were detected in spermatozoa and in respiratory tract cilia, respectively. Moreover, total absence of axoneme was seen in several sperm tails from this patient. The possibility that the features described are of genetic origin is discussed.

Adult↗
PubMedDate not supplied

[Biocompatibility and physico-mechanical properties of the new Venezia root canal sealer. In vivo and in vitro test according international standards].

At the moment, in most countries, there are laws in force which impose to the manufacturers well regulated testing in order to investigate and guarantee an acceptable biocompatibility of medical devices before their commercialization. Many international laboratories are committed to the definition of investigation methodologies and to the evaluation of biocompatibility in order to obtain research standards, capable to provide reproducible and comparable objective quantitative data. In every country, technical committees were put together for a standardization of methodological procedures, followed by European and international technical boards which proposed and codified methodologies and investigation approaches. UNI-EN-ISO laws contain all the results and constitute a reference point for any consideration on or evaluation of the biocompatibility of a medical device. Based on these laws, we evaluated the biocompatibility and determined the physical-mechanical characteristics of the new Venezia (Cabon S.p.A.) endodontic ZOE sealer. The Subcutaneous Implant Technique according Safavi et al. (in vivo test, ISO 10993: 1-6 Biological evaluation of medical and dental materials and devices) and Autian test of Emolysis on Rabbit Erythrocytes (in vitro test) allowed us to evaluate a good biocompatibility of the new product. Furthermore, its Setting and Working time, its radiopacity, Solubility and its Flow value completely satisfy the requirements of international standards (ISO/DIS 6876 Dental root Canal Sealing Materials). We can finally deduce that Venezia fulfil the ideal functional properties of an endodontic cements.

Animals↗