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Biomedical subjects

L Fonzi

Publications and source records attributed to L Fonzi.

At least 37 records · Page 2Linked to original sources
PubMed1980

[A rare case of continuous type spleno-gonadal fusion].

The authors present a case of continuous spleno-testicular fusion in a three year old child and emphasize the rarity of this condition, on the basis of an examination of the literature. The pathogenic mechanisms and clinical characteristics of this condition are studied in the light of the reported cases, and are discussed.

Adolescent↗
PubMed1980

Respiratory tract lesions induced in rabbits by short-term exposure to N-hexane.

New Zealand rabbits were exposed in inhalation chambers to 3,000 ppm of n-hexane 8h/d for 8 d, and the acute respiratory effects were studied by light and electron microscopy. Animals intoxicated showed morphological changes in the lung parenchyma characterized by centriacinar emphysema and scattered micro haemorrhages. Lung damage was most severe at the transition zone from terminal bronchiole to alveolar ducts. This centriacinar lesion consisted to degenerative and necrotic phenomena in bronchiolar epithelium with cellular desquamation, increased number of macrophages within proximal alveoli of alveolar ducts, increased number and size of lamellar bodies in alveolar type II cells, changes in the vascular endothelium. Focal subpleural atelectasis, alveolar and interstitial oedema were also found. The segmental distribution of the pulmonary lesions were confirmed by transmission electron microscopy.

Animals↗
PubMed1979

[Pulmonary damage in the rabbit caused by porcine pancreatic elastase and leukocyte lysate: unusual microscopic aspects].

Intratracheal injection of rabbit whole leukocyte homogenate induced emphysema-like lesions in rabbits. The lesions were produced only by preparations having elastinolytic activity. The pathological aspects appeared similar to those induced by the administration of porcine pancreatic elastase. The pulmonary changes, resembling several of the anatomic appearances of panacinar human emphysema, may be a suitable experimental model for studying histogenesis of panacinar human emphysema. Numerous abnormal fenestrations were present in air spaces walls and were a constant feature in opposition to that has been reported in elastase-treated hamsters. For the presence of a prominent dilatation of the periarterial lymphatic network, this experimental model might be used also for studying the ultrastructural features of pulmonary lymphatic vessels.

Animals↗
PubMedDate not supplied

Ultrastructural abnormalities in respiratory cilia and sperm tails in a patient with Kartagener's syndrome.

Ultrastructural abnormalities of spermatozoa and respiratory cilia have been reported in a male patient with Kartagener's syndrome and infertility. In this patient both respiratory cilia and sperm tails showed defects in radial spokes and dynein arms. Such defects are heretofore undescribed in the same subject with immotile cilia syndrome. Absence of both inner and outer dynein arms and absence of the inner dynein arms only were detected in spermatozoa and in respiratory tract cilia, respectively. Moreover, total absence of axoneme was seen in several sperm tails from this patient. The possibility that the features described are of genetic origin is discussed.

Adult↗
PubMedDate not supplied

[Biocompatibility and physico-mechanical properties of the new Venezia root canal sealer. In vivo and in vitro test according international standards].

At the moment, in most countries, there are laws in force which impose to the manufacturers well regulated testing in order to investigate and guarantee an acceptable biocompatibility of medical devices before their commercialization. Many international laboratories are committed to the definition of investigation methodologies and to the evaluation of biocompatibility in order to obtain research standards, capable to provide reproducible and comparable objective quantitative data. In every country, technical committees were put together for a standardization of methodological procedures, followed by European and international technical boards which proposed and codified methodologies and investigation approaches. UNI-EN-ISO laws contain all the results and constitute a reference point for any consideration on or evaluation of the biocompatibility of a medical device. Based on these laws, we evaluated the biocompatibility and determined the physical-mechanical characteristics of the new Venezia (Cabon S.p.A.) endodontic ZOE sealer. The Subcutaneous Implant Technique according Safavi et al. (in vivo test, ISO 10993: 1-6 Biological evaluation of medical and dental materials and devices) and Autian test of Emolysis on Rabbit Erythrocytes (in vitro test) allowed us to evaluate a good biocompatibility of the new product. Furthermore, its Setting and Working time, its radiopacity, Solubility and its Flow value completely satisfy the requirements of international standards (ISO/DIS 6876 Dental root Canal Sealing Materials). We can finally deduce that Venezia fulfil the ideal functional properties of an endodontic cements.

Animals↗
PubMedDate not supplied

[Enamel pearls: the ultrastructural aspects and morphogenesis hypotheses].

Five enamel pearls were examined by scanning electron microscope. Some external pearls presented a bare enamel surface, others were covered by a thin layer of cementum. The enamel pearls showed irregular dystrophic enamel surface or a thin layer without structure, rows of irregular Tome's processes pits, enamel caps and focal holes. Some enamel pearls revealed little areas of enamel surface resorption like-resorbing lacunae with, in some cases, areas of tissue repair.

Dental Enamel↗
PubMedDate not supplied

[In vivo and in vitro biocompatibility tests of endodontic cements].

The major goal endodontic therapy has been achieved by condensing filling materials into the root canal. It's not uncommon to find excess material into the periapical tissue. It therefore becomes obligatory to use fillings materials that have acceptable biocompatibility. The purpose of this investigation was to obtain a "toxicity profile" of some endodontics materials and to compare our observations to results present in literature. The gutta-percha and five endodontic filling cements were tested "in vivo" and "in vitro". The in vivo biocompatibility involved the placement of the test material in 10 mm. Teflon tubes with an outer diameter of 1.3 mm which were implanted subcutaneously into rats. The implants were left in situ for periods of 30 and 90 days. The "hemolysis test" is designed for "in vitro" evaluations. The histological examination showed different intensity and extent cellular responses. In some cases severe infiltration of inflammatory cell and areas with necrotic were seen. At conclusion, the endodontics material evaluated showed slight, moderate and severe reactions; therefore a different pattern in tissue response.

Animals↗