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Biomedical subjects

L Forman

Publications and source records attributed to L Forman.

53 records · Page 3Linked to original sources
PubMed1982

Polymorphonuclear cell chemotaxis to secretions of pathogenic and nonpathogenic Trichomonas vaginalis.

Polymorphonuclear cell chemotaxis to secretions of pathogenic and nonpathogenic strains of Trichomonas vaginalis were investigated. Cells from three groups, laboratory workers, patients with urogenital symptoms, and asymptomatic patients attending an antenatal clinic, all showed greater response to secretions of pathogenic strains, when the secretion was dilute. At higher concentrations of secretion, responses to both strains were similar, except in the pregnant group, where increased chemotaxis to pathogenic strains was still evident.

Animals↗
PubMed1980

In vitro attraction of polymorphonuclear leucocytes by Trichomonas vaginalis.

Boyden chambers were used to investigate the attraction of polymorphonuclear leucocytes to T. vaginalis. Chemotaxis to live organisms was demonstrated, and chemotaxis to T. vaginalis supernatant was shown to be concentration dependent. Both chemokinesis and true chemotaxis characterized the response to supernatants. There was no chemotaxis to the supernatant after it had been heated to 60 C for 1 hr, or to the supernatant from formalin-fixed T. vaginalis. The chemotactic factor in the supernatant did not pass through a dialysis membrane. Protein was found in the supernatant of T. vaginalis suspensions.

Adult↗
PubMed1979

Actinic chickenpox. Light-distributed varicella eruption.

When areas of the skin which are normally covered become sunburnt just before chickenpox eruption, there occurs a marked intensification of the rash on the freshly burnt parts. This phenomenon is not widely known. Its history, published reports and our original observations on this 'actinic' chickenpox are presented, with comment on its pathogenesis.

Adult↗
PubMed1977

Oral non-dystrophic bullous eruption mainly limited to the gingivae: a mechano bullous response. A variant of cicatricial mucous membrane pemphigoid?

Fourteen patients with recurrent blistering entirely restricted to the mouth have been observed for up to 7 years. Their average age was 52 years, and there was a predilection for females (ratio 2-5:1). Patients presented with thick-roofed blisters and denuded, red, boggy areas of mucosa. The area of maximal involvement with the labial gingiva, and whilst the blisters would arise spontaneously, mechanical trauma was the obvious provocative factor in all patients. Gentle friction on normal looking mucosa would produce a bulla which became blood filled. Re-epithelialization usually occurred within 1-3 weeks, with no scarring. Biopsies showed subepithelial bullae, and direct immunofluorescence was positive in the basement membrane zone of 2 of the 5 cases examined. The most striking feature was the extreme fragility of the epithelial attachment to the underlying corium, as shown by a useful clinical test with a probe. In 10 patients, the condition gradually remitted and the probe test became difficult to perform. The term acquired oral non-dystrophic epidermolysis bullosa was considered for the diagnosis, although a forme fruste of cicatricial mucous membrane pemphigoid remained an alternative.

Adult↗
PubMed1975

Bloom's syndrome: a probable new case with cytogenetic findings.

A 19-year-old Jordanian girl, born to first-cousin parents, has most features of Bloom's syndrome but is tall and has secondary amenorrhoea. Blood and skin cultures revealed a normal diploid female complement but about one-quarter of the cells show chromosome or chromatid gaps, breaks and rearrangements. These abnormalities were localized after trypsin banding and having been found non-randomly distributed along the chromosomes.

Abnormalities, Multiple↗
PubMedDate not supplied

Comparative chromosome morphology in three Callitrichid genera: Cebuella, Callithrix, and Leontopithecus.

A G-band karyotypic analysis was carried out in individual species groups of three Callitrichid primate genera: Cebuella, Callithrix, and Leontopithecus. Within Callithrix, the karyotypes of the morphologically distinct and geographically isolated morphotypes C. jacchus jacchus and C. jacchus penicillata were identical. Within the lion tamarin genus, Leontopithecus, the karyotypes of the three morphotypes (L. rosalia rosalia, L. rosalia chrysomelas and L. rosalia chrysopygus) were also indistinguishable from one another. These results are consistent with the taxonomic designation of subspecies rank to the different morphotypes. A comparison of type specimens among the three Callitrichid genera showed that their phyletic radiation has been paralleled by a limited number of chromosome rearrangements and a relatively high amount of karyotypic invariance. A fusion/fission event has been postulated to account for the difference in diploid number between Cebuella (2n = 44) and the other species (2n = 46). The karyotype of Callithrix jacchus was found to be more directly derived from Cebuella than was that of Leontopithecus. These findings differ from the previous proposition that Leontopithecus might have diverged from a common Callitrichid ancestor before the emergence of the genus Callithrix.

Animals↗
PubMedDate not supplied

Self-treatment for obsessive compulsive disorder using a manual and a computerized telephone interview: a U.S.-U.K. study.

Bt steps is a patient-centered behavioral therapy program that uses a manual and a computer-driven interactive voice response system to assess and treat obsessive compulsive disorder. This nine-step program contains a self-assessment module and a self-treatment module that provides teaching on exposure and ritual prevention. The patient reads about the steps in a manual and then uses a touch-tone telephone to contact the program, in which a recorded voice conducts the interview. Of 40 patients in an open 12-week trial in the United States and London, 35 completed the self-assessment module, and 17 completed at least two sessions of exposure and ritual prevention. The system produced statistically significant improvements on measures of obsessive compulsive disorder.

Adult↗