Biomedical subjects

L Fortier

Publications and source records attributed to L Fortier.

At least 19 recordsLinked to original sources

PubMed1995

Similar distribution of trans fatty acid isomers in partially hydrogenated vegetable oils and adipose tissue of Canadians.

The objective of this study was to evaluate the composition of trans fatty acids in the subcutaneous fat of Canadians relative to the composition of dietary sources of trans fatty acids. The fatty acid composition, total trans acid content, and the geometric and positional isomer distribution of unsaturated fatty acids of subcutaneous adipose tissue of Canadians were determined using a combination of capillary gas-liquid chromatography and silver nitrate thin-layer chromatography. The mean total trans fatty acid content was 6.80% at the abdominal site and 5.80% at the lateral thigh site. Total trans isomers of linoleic acid (18:2n-6) were present at 1.17% in abdominal and 1.59% in thigh adipose tissue, with 9c.12t-18:2 being the most prevalent isomer followed by 9c-13t-18:2 and 9t,12c,-18:2. The oleic acid (18:1) trans isomer distribution in adipose tissue differed from that in butter fat, but it was similar to that in partially hydrogenated vegetable oils. The reverse was true for the 18:1 cis isomers. Total 18:1 trans isomers were inversely related to 18:2n-6 content in adipose tissue, suggesting the trans fatty acid intake is inversely related to the intake of linoleic acid. Partially hydrogenated vegetable oils appear to be the major source of trans fatty acids in adipose tissue of Canadians.

Adipose Tissue↗

PubMed1989

Mortality rates among patients with end-stage renal disease in Canada, 1981-86.

We assessed the mortality rates by age, sex, race, blood type, primary diagnosis, treatment and transplantation history of 8432 patients in Canada for whom end-stage renal disease (ESRD) was diagnosed between 1981 and 1986. Significant differences in the probability of dying were found between those with and without diabetes mellitus, between those who had received a renal transplant and those who had not, between white and nonwhite patients and between various age groups. The mortality rates of the ESRD patients were at least three times higher than those of the general Canadian population. Primary diagnosis and treatment were significantly associated with the risk of dying among the ESRD patients. For those who had received a transplant, the length of time spent waiting for a transplant was positively associated with the risk of death from ESRD. Patients who had received peritoneal dialysis before transplantation had a higher risk of death than those who had received either hemodialysis (risk ratio 1.3) or transplantation (risk ratio 3.2) as the first treatment. No significant differences were found in the cause of death between those who had received peritoneal dialysis and those who had received hemodialysis. Almost half of the deaths among women without diabetes who had received a transplant were due to infection.

Adolescent↗

PubMed1984