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Biomedical subjects

L Frána

Publications and source records attributed to L Frána.

14 recordsLinked to original sources
PubMed2001

[Prednicarbate and cetirizin dihydrochloride in the treatment of atopic eczema in the acute phase in children].

The aim of the study was to monitor the impact of local application of prednicarbat (Dermatop, Hoechst-Biotika) and oral administration of cetirizin (Zyrtec, UCB) on the development of the acute stage of atopic eczema (AE) or acute exacerbation of the chronic form of AE in two groups of patients. Effectiveness and safety of both preparations were being evaluated in 80 children undergoing an outpatient treatment. In the first group, only prednicarbat cream was applied to affected places twice a day for a maximum of 10 days, while in the other group also cetirizin was administered once a day in a dosage according to the patient's age. On the treated places, erythema, infiltrate and excoriation were evaluated with respect to the intensity of manifestation. The results of the study show favourable effects of both preparations on AE development, already during the first days of the therapy. In both groups there was a complete remission of the monitored symptoms in more than 80 per cent of the patients. There was no deterioration of the disease in any patient, and no cases of adverse reactions were registered.

Acute Disease↗
PubMed1991

[Aarskog's syndrome].

The authors described the rare Aarskog syndrome in a 6-year-old boy, associated with left-sided Brown's syndrome. Another 4-year-old boy came from an affected family where the brother suffered also from Aarskog's syndrome and in the mother some microsymptoms were detected. The authors recommend that patients who on examination of a refraction defect or strabism display uncommon features in the face or other parts of the body should be always subjected to a general examination incl. genetic examination.

Abnormalities, Multiple↗
PubMed1976

Infantile cortical hyperostosis.

The genetic aspects of infantile cortical hyperostosis are discussed. A pedigree is presented, based on the history and clinical and radiological investigations of all living members of the family, with data from 11 cases with the condition in two generations, and one possible case from a third generation. The data suggest that an autosomal dominant gene with varying expressivity could be responsible in this family and, though the genetic outlook is unfavourable, it is fully balanced by the benign character of the disease. A chronic form of infantile cortical hyperostosis affecting 2 girls and 1 boy in the family is described with a follow-up of 3 to 5 years. There was no deterioration in the general state of health of the patients and no abnormality was detected in laboratory investigations. At the end of the second year of life, curving of the long bones was usually present radiologically and the appositionless corticalis was paper thin with extended marrow cavity. With increasing age the bowing of the bones became less noticeable (but can be permanent in some cases), the corticalis thickened, while marrow cavity volume decreased. In the marrow cavities the remains of insufficiently resorbed original hyperostoses were seen. All the affected bones exhibited both numerous Park's stress lines and osteoporosis, more marked in the bones of the lower extremities. Even these changes disappeared with increasing age. Neither the metaphyses nor epiphyseal ossification centres were affected by the condition.

Child, Preschool↗