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Biomedical subjects

L Franchini

Publications and source records attributed to L Franchini.

11 recordsLinked to original sources
PubMed1996

Fluvoxamine and lithium in long-term treatment of unipolar subjects with high recurrence rate.

We prolonged from 24 to 36 months a follow-up study of unipolar subjects with a high probability of recurrence treated with fluvoxamine (n = 32) or lithium (n = 32). During the extra observation period, two patients developed mania and were excluded from the study. There were no further recurrences in either the lithium or the fluvoxamine group. In our sample, previous prescriptions of tricyclics seem to predict a worse prognosis.

Adult↗
PubMed1995

A family study of schizotypal disorder.

Direct, blind interviews were used to study the risk for and prevalence of DSM-III-R Axis I and II disorders in 93 first-degree relatives of outpatients with schizotypal personality disorder (SPD) and outpatients with other personality disorders. Risks for SPD (at a slightly loosened diagnostic threshold) and schizoid personality disorder were significantly higher in the families of probands with SPD. Schizophrenia was present only among relatives of probands with SPD, accounting for a morbid risk of 4.1 percent. Neither familial risks for mood and anxiety disorders nor the prevalence of other Axis II disorders significantly differed in the two groups of relatives. It is suggested that SPD is a familial disorder representing a phenotypic expression of liability to schizophrenia.

Adolescent↗
PubMed1995

Postoperative infections after neurosurgery and cardiosurgery: the value of labelled white blood cells.

Post surgical-infections in neurosurgery and cardiosurgery are infrequent, but potentially fatal complications. The aim of this study was to compare the utility of 99mTc-HMPAO white blood cells scintigraphy (WBCS) with traditional diagnostic approaches in post-surgical complications, in order to obtain timely demonstration of a current infection. We studied 23 patients with a suspicion of infection after major cardiosurgery or neurosurgery. Planar imaging was performed at 4 and 20 hours after injection of autologous white blood cells labelled with 99mTc-HMPAO. Eight patients underwent CT scan, but only in one case did CT findings lead to a clear definition of a bulky inflammation process of the chest. WBCS identified one or more sites of focal increased uptake of the radiopharmaceutical in 6 patients: five of these patients were scheduled for a "second look" surgical operation that confirmed the sites and extention of the primary infection, thus confirming the presence of an abscess. In 3 cases WBCS showed only a weak increase of focal uptake and in 14 cases there was no evidence of abnormal uptake. The absence of deep infections was confirmed at surgery or at clinical follow-up. Thus WBCS seems to be useful in evaluating patients with the clinical suspicion of infective complications after surgery.

Adult↗
PubMed1994

A 24-month follow-up study of unipolar subjects: a comparison between lithium and fluvoxamine.

The authors compared rates of new episodes in a sample of 64 unipolar subjects treated with fluvoxamine (n = 32) and lithium (n = 32) during a follow-up period of 24 months. Unipolar patients on lithium treatment had a worse outcome with a higher frequency of new recurrences compared with of new recurrences compared with patients on fluvoxamine during the course of preventive treatment.

Adult↗
PubMed1993

A study of relapses in subjects with mood disorder on lithium treatment.

In a sample of 213 mood disorder subjects on long-term lithium treatment, we analyzed the recurrence indices of relapses during the prophylactic treatment period. The differences found in the recurrence rates were due to the current age and age of onset, duration of illness and polarity of the probands. The patients with personality disorders showed the worst relapse indices and could represent a group of mood disorder subjects with a bad outcome of lithium treatment.

Aging↗
PubMed1991

[The CT aspects of a case of chondromatosis of the temporomandibular joint].

The CT picture of a case of synovial chondromatosis of the temporomandibular joint is described. The distinctive feature of the case was the presence of ossified loose bodies surrounding the head of the condyle. Three-dimensional image reconstruction was also employed to obtain better overall visualization of the alterations.

Chondromatosis, Synovial↗
PubMed1989

[CT in the follow-up of rectal neoplasms].

CT-scans were performed in the follow-up of 124 patients surgically treated for rectal carcinoma. CT allowed direct visualization of possible local recurrences and infiltration of neighbouring structures chiefly muscles and bones; it can also prove post surgical abscesses, metastatic spreads to lymph nodes and other structures such as liver, lung and bones; many of these lesions cannot so quickly and safely be demonstrated by other investigations. CT is also very helpful in radiation therapy planning. A CT guided percutaneous fine-needle aspiration biopsy can discriminate post surgical fibrosis from initial recurrences.

Biopsy, Needle↗
PubMed1984

[Computerized tomography in the study of rupture of abdominal aneurysms].

The authors present the CT aspect of 3 patients with massive retroperitoneal hemorrhage, caused by leaking of aneurysms of the lumbar aorta (2 cases) and of the right iliac artery (1 case). CT is a first choice examination in studying suspect ruptured aneurysms; in fact it can show dimensions and place of the aneurysm, and it is also possible an exact evaluation of retro and intraperitoneal hematoma.

Aged↗