'Mice' in the joint.
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Chondromatosis, Synovial↗
Biomedical subjects
L Fryer
Publications and source records attributed to L Fryer.
An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts.
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Amino Acid Sequence↗
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.
Structure-activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined by taking advantage of a concise synthesis that allowed diverse functionality to be explored at each position in a template. An ex vivo rat model and an in vivo rabbit model of stromelysin-induced cartilage degradation were used to further optimize these analogs for oral activity and duration of action. The culmination of these modifications resulted in CGS 27023A, a potent, orally active stromelysin inhibitor that blocks the erosion of cartilage matrix.
Administration, Oral↗
Mesodiverticular band: a cute little bleeder.
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Aged↗
Marijuana psychosis: a case report.
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Adult↗