Microorganisms isolated from pulp chambers.
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Bacteria↗
Biomedical subjects
L Fujimoto
Publications and source records attributed to L Fujimoto.
A simple and compact total artificial heart for temporary use.
Thromboembolism and anatomic fit are the major issues to be addressed in the design of a heart replacement device for total circulatory support. In an attempt to overcome these problems, a simple 70 mm3 displacement pusher plate, low pressure, pneumatically driven TAH was developed for temporary use. For optimal anatomic fit, easy implantation, and better flow patterns, the 5.7 X 10.7 cm total artificial heart (1) TAH was made of two essentially flat pumps integrated into a single unit. This single package approach avoids the dead space that occurs between the two pieces of conventional TAH and thus minimizes overall volume. It was designed to be positioned in the pericardial sac in a fashion similar to the natural ventricles and, based upon previous anatomic studies, fit in the average sized adult patient. In contrast to conventional free diaphragm pumps, the diaphragms of this TAH are supported by pusher plates that have a unique guide mechanism at the center to ensure a linear-controlled diaphragm motion and consequent uniform blood flow distribution. The guide of each pusher plate nests into the other, resulting in minimal thickness of the package. By using a simple displacement transducer, reliable output monitoring, with the possibility of selection of various pumping modes and adjustment of stroke volume, is possible. The authors anticipate this efficient and practical TAH to be a suitable temporary heart replacement device.
Heart Failure↗
In vitro and in vivo performance evaluation of a totally implantable electrohydraulic left ventricular assist system.
The biolized electrohydraulic left ventricle assist devices were tested in 14 calves with an average survival time of 162 days and as long as 250 days without the use of anticoagulants. In vitro, the system pumped 4.1 L/min at a low 4.8 mmHg fill pressure with a mean afterload of 100 mmHg and rate of 46 bpm. A flow rate of 13.5 L/min was observed at 155 bpm and 110 mmHg afterload. Motor frequency and current increased with increasing flow rate (162 Hz, 0.67 amp at 2.5 L/min; 484 Hz, 2.43 amp at 13.5 L/min). Flow rate did not change significantly with afterload pressure. The complete system was implanted in a 100 kg calf. Synchronization of the blood pump with the natural heart was demonstrated at heart rates of 85 to 167 bpm. The synchronized flow rate varied from 6 to 10.5 L/min despite the considerable heart rate changes and stroke variations. The system hemodynamic performances were acceptable and met NIH requirements.
Animals↗
Study of heat dissipation to the lung from a thermal ventricular assist system.
The thermally powered left ventricular assist system (LVAS) requires that heat be dissipated to surrounding lung tissue and blood. This acute study was conducted in three anesthetized calves (weighing 84.3 +/- 14.3 kg) to evaluate the mechanisms involved in the dissipation of heat to the lung tissue. The heaters were placed in contact with the left lung surface and skeletal muscle tissue. Compared to the muscle tissue, heat flux to the lung was approximately three times higher for the same surface temperatures. For a constant heat flux, lung interface temperature tended to vary inversely with the cardiac output and ventilatory flow. This preliminary study demonstrated that the level of heat generated by the thermal LVAS can be effectively dissipated to the lung, with the convection mechanisms of airflow and blood flow playing a major role.
Animals↗
An intrathoracic left ventricular assist system: utilization of results from a development program.
An intrathoracic, electrohydraulically actuated, left ventricular assist system (LVAS) was subjected to formal device readiness testing. Endurance testing was initiated on eight systems before testing was halted due to failure of four of the systems. Three failed due to environmental leakage. Solutions were straightforward, involving gasket changes and o-ring resizing. The fourth failure involved a magnetic coupling piston swelling and seizing. The failure was attributed, after long investigation, to hydrogen adsorption by the samarium-cobalt magnets. An unknown number of coupling magnets were affected in this fashion, necessitating complete replacement of magnets to resolve the problem. However, this was beyond the scope of the program, and no further endurance testing was accomplished. The test experience of the Nimbus/CCF LVAS has demonstrated all functional aspects of the complete LVAS, both in vitro and in vivo, and the endurance and reliability potential is indicated as well. Although the LVAS program is currently inactive, its legacy of technical innovations continue to drive the development of other medical devices.
Animals↗