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Biomedical subjects

L G Alexander

Publications and source records attributed to L G Alexander.

14 recordsLinked to original sources
PubMed1996

Healthcare reform.

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Attitude to Health↗
PubMed1985

Right ventricular subendocardial infarction in a patient with pulmonary hypertension, right ventricular hypertrophy, and normal coronary arteries.

Right ventricular infarction is usually associated with coronary artery disease and concomitant left ventricular infarction. Isolated right ventricular subendocardial necrosis was discovered at autopsy in a 52-year-old woman with pulmonary hypertension, right ventricular hypertrophy, and normal coronary arteries, who died with septicemia 41 days after mitral valve replacement. This represents the first well-documented report of isolated right ventricular subendocardial infarction associated with normal coronary arteries.

Bioprosthesis↗
PubMed1983

Long-term results of pulmonary resection for atypical mycobacterial disease.

From 1967 through 1981, 40 pulmonary resections were performed in 37 patients with Mycobacterium intracellulare infection. The patients ranged in age from 24 to 67 years, and 86% were men. Smoking and alcohol abuse seemed to be predisposing factors. Localized atypical mycobacterial infection unresponsive to chemotherapy was the operative indication for 38 of the 40 resections. All patients had cavitary disease. Mean length of preoperative drug treatment was 22 weeks. Sensitivity studies showed a very high incidence of in vitro drug resistance. Twenty-five patients were converted to sputum-negative status preoperatively; however, 23 of these had positive smears or cultures from their resected specimens. Resections performed included upper lobectomy in 31 patients, upper and middle lobectomy in 2 patients, upper lobectomy plus superior segmentectomy in 3, left completion pneumonectomy in 2, and wedge resection in 2. Two patients underwent staged bilateral upper lobectomies. There were no perioperative deaths. Complete follow-up in 33 patients (mean, 94 months) revealed only two reactivations at 3 and 5 years postoperatively. One of these patients is well following completion pneumonectomy 9 years after his first operation; the second patient responded to reinstitution of three-drug chemotherapy and is well 5 years later. Thirty-one patients have remained entirely free of disease. Excisional surgery remains the treatment of choice for localized M. intracellulare pulmonary infection.

Adult↗
PubMedDate not supplied

Abdominal wall reconstruction with a vascular external abdominal oblique myofascial flap.

A myofascial island flap for abdominal wall reconstruction was based on the lumbar component of the external abdominal oblique muscle and supplied by a major neurovascular pedicle consisting of branches of the cranial abdominal artery, cranial hypogastric nerve, and a satellite vein. The flap was elevated and sutured into a 10 cm x 10 cm body wall defect in five dogs. The dogs were observed for 26 to 28 days. Abdominal wall contour and function were preserved. All dogs developed seromas, two of which became infected. One dog developed a hernia at the dorsal margin of the flap, which was repaired. At necropsy, there was no evidence of dehiscence in any of the dogs. Loose adhesions of omentum to the inner surface of the flap occurred in four dogs. Results of histologic examination confirmed the clinical impression of flap viability. The myofascial island flap has a wide range of mobility over the ventral and caudal areas of the abdomen and lateral thoracic wall. It has potential clinical use for reconstruction of defects within its arc of rotation.

Abdominal Muscles↗