Biomedical subjects
Publications and source records attributed to L G Barabanov.
Hypophyseal, sehual gland, and adrenocortical functions have been examined in 15 patients with noncomplicated gonorrhea, in 13 ones with chronic gonorrhea complicated by scrotal organs inflammation, adn in 15 ones with that complicated by prostatitis. The complex of therapeutic meacures including ethymisole and inductothermy had a correcting effect on the hormonal systems functioning.
Traditional therapy of patients with new and chronic gonorrhea complicated with prostatitis has augmented testicular androgenic insufficiency, hyperprolactin- and hyperprogesteronemia, and estrogen share in the hormonal profile; inclusion into the complex of therapeutic measures of sustanon-250, a long-acting androgen, and of raveron have not corrected the hormonal ratio. Parlodel has normalized the hormonal parameters in cases with initially high blood prolactin levels and stages II-III oligozoospermia.
Chymotrypsin, a proteolytic enzyme included in combined therapy of 27 patients with gonorrhea complicated by the scrotal organs inflammation, has normalized the functions of the hypophyseo-gonadal and hypophyseo-adrenal systems, i.e. hypophyseal luteotropic function, adrenocortical gluco- and mineralocorticoid functions, and testicular androgenopoiesis. Hyperprolactin- and hyperprogesteronemia persisted after therapy, hyperestrogenism and follitropic hypofunction of the hypophysis have developed, that may become the reason of stable pathospermia and disordered fertility after therapy of complicated gonorrhea.
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The results of using ampicillin in treatment of 54 gonorrhea patients (41 males and 13 females) previously treated with other antibiotics without success are presented. Ampicillin was used in a daily dose of 500 mg administered 5 times a day at equal intervals and an 8-hour interval during the night time. The course dose was 6--10 g. Patients with chronic and fresh gonorrhea with insignificantly pronounced symptoms were subjected to immunotherapy before the treatment with ampicillin. Pure gonococcal strains sensitive to ampicillin were isolated from 16 patients before the ampicillin use. Clinical improvement after the treatment with ampicillin in most of the patients was observed by the end of the 1st day and was evident from elimination of the urethral discharges, absence of urination colics and urea clarification. Etiological recovery was recorded in all the gonorrhea patients due to the treatment with ampicillin. All the patients were crossed off the register. The clinical and laboratory investigations showed high efficiency of ampicillin in treatment of gonorrhea relapses. The antibiotic is rapidly absorbed into the blood. Its therapeutic blood levels are maintained during 24 hours. It is well tolerated by the patients.