PubMed Health⌕ Search

Biomedical subjects

L G Dukov

Publications and source records attributed to L G Dukov.

16 recordsLinked to original sources
PubMed1999

[Effective correction of lung hyperinflation in pneumonia using positive end-expiratory pressure].

AIM: Study of PEEP effects on breathing biomechanics in patients with pneumonia. MATERIALS AND METHODS: In 37 patients with pneumonia breathing biomechanics was studied using Masterlab (Jaeger). PEEP (3-10 cm H2O) was employed during 20 min. RESULTS: Sputum expectoration, expiration and inspiration were improved, lung hyperventilation observed in pneumonia reduced after PEEP. CONCLUSION: There is early expiration obstruction of the airways in pneumonia. PEEP removes this obstruction through control of lung hyperinflation. Thus, PEEP can be applied in the treatment of pneumonia.

Acute Disease↗
PubMed1997

[The effect of positive end-expiratory pressure on respiratory biomechanics in bronchial asthma].

The influence of PEEP breathing has been studied in 43 patients with exacerbation of bronchial asthma (BA) during 20 min in resistance of 5, 7 or 9 sm. Sputum expectoration and inspiration were found improved after PEEP breathing. Moreover, in some patients mild BA attacks relieved. Lung hyperinflation, bronchial obstruction reduced. A positive effect was observed in moderate asthma in PEEP breathing of 7 and 9 sm more frequently. This, PEEP breathing can be applied in the treatment of BA.

Adult↗
PubMed1992

[Disorders of the protease-antiprotease system of a bronchial washout in patients with bronchiectasis and the means for their correction].

Patients with bronchiectatic disease show imbalance between the activity of proteolytic enzymes and their inhibitors contained by bronchial wash-out, manifesting in a reduction of the inhibitory potential and a rise of the activity of trypsin-like proteinases. After the standard basic treatment the protease-antiprotease system in bronchial wash-out shows a definite improvement. Endobronchial therapy with contrykal given in a dose of 20-30 thousand ATpE for 5-7 days does not ameliorate imbalance in the protease-antiprotease system in bronchiectatic disease patients as compared to the common basic therapy.

Adult↗
PubMed1991

[Procoagulant and proteolytic activities of leukocytes in the foci of acute abscesses and gangrene of the lungs].

Essential role in development of acute purulent destruction of the lungs in attributed to proteinases of polimorphonuclear leukocytes. Poor localization of the destruction focus seems to result from low procoagulant activity of pulmonary macrophages. If the activity of purulent and destructive process stands high the ability of phagocytes to synthesize and release proteinases is realized fully. epsilon-Aminocaproic acid prohibits phagocytic proteolytic activity from growing under the influence of stimulators. Correction of defective leukocytic proteolysis and mononuclear activity can be done with prodigiozan, streptokinase and epsilon-aminocaproic acid.

Acute Disease↗
PubMed1980

[Ventilation-perfusion ratios and pulmonary shunt].

A group of 63 healthy subjects aged from 17 to 29 years were studied in a sitting posture. The following indices of pulmonary ventilation were revealed: Vd, phys/VT-30 +/- +/- 0.6%, AaDO2-10 +/- 0.9 mm Hg, aADCO2 (PA, CO2 = = Pet, CO2)-5.0 +/- 0.4 mm Hg, Qva/QT (air)-2.3 +/- 0.3% Qs/QT (O2)-1.8 +/- 0.2%. In general VA/Qc is normal being 0.86 +/- 0,03. No differences in VA/Qc are recorded in males and females. The anatomic shunt and perfusion of nonventilated alveoli play the leading role in the formation of QVa/QT in healthy persons.

Adolescent↗
PubMedDate not supplied

[The differential use of fibrinolysis activators and inhibitors in treating acute abscesses and gangrene of the lungs].

The authors examined 25 patients with acute abscesses and gangrene of the lungs to study the condition of the phagocyte system and its effect on processes of fibrin formation and destruction in the focus of inflammation. They found marked increase of the number of polymorphonuclear leucocytes and decrease of alveolar macrophages in lavage fluid of the diseased lung. The fibrinolytic, procoagulant, and oxygen-dependent metabolic activity of phagocytes was increased. With the degree of these changes and the clinical and endoscopic signs of the activity of the inflammatory process taken into account, the choice of the fibrinolysis activators and inhibitors for endobronchial administration can be differentiated and the results of treatment improved.

Acute Disease↗