Biomedical subjects

L G Gomez

Publications and source records attributed to L G Gomez.

10 recordsLinked to original sources

PubMed1983

Aspergillus epiglottitis.

A 21-year-old woman with acute lymphocytic leukemia developed clinical and radiographic signs of epiglottitis. Premortem and postmortem histologic studies showed invasive aspergillosis; Aspergillus flavus was grown in culture. The necrotizing nature of this infection is explained by the predilection of Aspergillus sp. for invasion of blood vessels. The usual causative agents of epiglottitis are bacteria; the association with fungal infection has not been previously described.

Adult↗

PubMed1983

Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin.

Among 32 neuroendocrine carcinomas of the skin, 11 were from patients with previous or concomitant squamous carcinoma. The medical records and pathologic material for these 11 cases were reviewed, and the diagnosis of neuroendocrine carcinoma was confirmed in each instance by electron microscopy. In two cases, the squamous and neuroendocrine carcinomas were admixed, but each preserved its identity and transition between the two was not identified. Despite the lack of evidence for origin from a single cell, the observations nevertheless indicate a common carcinogenetic influence for squamous and neuroendocrine carcinomas of the skin.

Adenocarcinoma↗

PubMed1982

Immunoblastic lymphoma of small intestine complicating late-onset immunodeficiency.

A malignant lymphoma of the small bowel developed in a 75-year-old woman who had severe late-onset hypogammaglobulinemia with intestinal malabsorption and nodular lymphoid hyperplasia. The tumor arose in the midst of the abnormal lymphoid follicles and appeared to be of B-immunoblastic type. Immunoperoxidase staining, however, failed to reveal immunoglobulins in the tumor cells. In vitro immunologic studies showed that immunoglobulin production by the patient's peripheral lymphocytes had decreased and that this decrease was mediated by hydrocortisone-sensitive suppressor cells. These findings suggest that nodular lymphoid hyperplasia of the intestine in the context of severe immunodeficiency is a premalignant condition.

Agammaglobulinemia↗

PubMed1982

Systemic amyloidosis associated with a benign mesenteric lymphoid mass.

This report describes the case of a patient with a mesenteric lymphoid mass with clinical and histologic features suggestive of giant lymph node hyperplasia (GLH) who died as a result of complications related to systemic amyloidosis. To our knowledge, this is only the second case of amyloidosis associated with a benign mesenteric lymphoid mass reported in the literature. The possible relationship of amyloid with GLH will be discussed.

Adult↗

PubMed1982

In vivo steroid studies in luteoma of pregnancy.

Endocrine studies were performed in 2 cases of luteoma of pregnancy. Even though both luteomas were discovered incidentally at the time of postpartum tubal ligation and cesarean section, they were found to be functionally active, secreting several androgens. Steroid concentrations were measured in the ovarian vein blood draining the luteoma in one patient and in peripheral vein blood in both patients. Peripheral testosterone, androstenedione, and dihydrotestosterone concentrations were increased severalfold higher than the normal controls and were comparable to the concentrations reported previously in virilizing luteomas. Progesterone, 17 alpha-hydroxyprogesterone, and estradiol concentrations were increased as well. The concentrations in the ovarian vein were significantly greater than those in the peripheral vein, which indicates active secretion of these steroids by the luteoma. In spite of the high concentrations of androgens, neither the mothers nor the infants were virilized. Concentrations of androgenic steroids in the cord blood were in the normal range. Determination of steroid concentrations in the serum, taken at intervals post partum, indicated spontaneous regression of the luteomas.

Adult↗

PubMed1981

Clinical and hormonal studies in hyperthecosis of the ovaries.

Endocrine studies were performed in five women with ovarian hyperthecosis. Measurement of testosterone (T), dihydrotestosterone (DHT), androstenedione (A), 17 alpha-hydroxyprogesterone (17-OHP), progesterone (P), estradiol (E2), and estrone (E1) in the peripheral and ovarian vein serum obtained simultaneously at the time of surgery indicated that the hyperthecotic ovaries secreted large amounts of potent androgens T and DHT. There was a less marked increase in A secretion. Peripheral P and 17-OHP levels were elevated, with a significant peripheral ovarian gradient. E1 comes entirely from peripheral conversion, while at least a portion of E2 comes from direct secretion from the ovaries. Circulating FSH and LH levels were low or normal. The gonadotropin response to LH-RH was in the normal range. No patient ovulated with Clomid treatment. The hirsutism did not improve with ovarian suppression with birth control pills, possibly because of the absence of tonic elevation of LH. The hypothalamic pituitary physiology in hyperthecosis is different from that in polycystic ovarian disease.

Adult↗

PubMed1979

Uterine leiomyosarcoma.

A series of uterine leiomyosarcomas was reviewed in an attempt to assign prognostic significance to clinical and pathologic features. Extension of the sarcoma at the time of initial diagnosis was associated with a dismal outcome; no patient with disease beyond the confines of the uterus survived. Histologic grade was a useful prognostic feature, although low-grade sarcoma can be associated with metastases. Mitotic count was also useful in prognosis, although it did not correlate as well with clinical outcome as did histologic grade. There was no number of mitoses below which the diagnosis of leiomyosarcoma was excluded.

Adult↗

PubMed1979

Separate pancreatic gastrin cell and beta-cell adenomas: report of a patient with multiple endocrine adenomatosis type 1.

A patient initially showed symptoms of peptic ulcer disease in 1953 and was later found to have hypercalcemia and hyperparathyroidism. Peptic ulcer symptoms persisted after parathyroidectomy, and results of studies provided evidence of the Zollinger-Ellison syndrome. Evaluation of the patient's family showed a classic pattern of multiple endocrine adenomatosis type 1. The patient underwent total gastrectomy and excision of a gastrin cell adenoma in 1971 with relief of symptoms, but with persistent hypergastrinemia. He remained in good health until January 1976, when symptoms of hypoglycemia developed. Results of laboratory studies were compatible with the diagnosis of a pancreatic beta-cell adenoma. At the time of operation, an adenoma of the head of the pancreas was found. The tumor was excised; no other metastatic tumors were found. The tumor was compatible with a beta-cell adenoma and was found to contain high concentrations of insulin; there was no important amount of gastrin. Symptoms of hypoglycemia have entirely disappeared.

Adenoma↗

PubMed1979

Human pulmonary dirofilariasis presenting as a solitary pulmonary nodule.

A case of human pulmonary dirofilariasis had positive serologic testing postoperatively. Increased awareness of this entity as a cause of solitary pulmonary nodules may lead to preoperative serologic and intradermal testing, and to the possibility of arriving at a preoperative diagnosis.

Diagnosis, Differential↗

PubMed1979

Papillary endothelial proliferation in cystic lymphangiomas. A lymphatic vessel counterpart of Masson's vegetant intravascular hemangioendothelioma.

Papillary endothelial proliferation similar to that of Masson's "vegetant intravascular hemangioendothelioma" of the blood vessels was observed in two cases of cystic lymphangiomas. They are believed to be the lymphatic vessel counterpart of Masson's entity. Twenty-five other specimens of various lymphangiomas examined (18 patients) did not contain the same change. As was emphasized previously for Masson's lesions, lymphangiomas containing similar endothelial changes should also not be mistaken for malignant vascular tumors, since in these two cases, no unusual clinical course supervened. Although the histogenesis of the lesion as proposed by Masson has been disputed, both primary and secondary endothelial proliferation seem to remain possible in the formation of these lesions.

Cell Division↗