Biomedical subjects

L G Kuz'menko

Publications and source records attributed to L G Kuz'menko.

At least 19 recordsLinked to original sources

PubMed2005

[Emergency care for acute wound entering of plutonium and americium into the body (real case)].

The article describes a case of slowly soluble plutonium and americium compounds entering human body via skin wound. During the wound healing, the authors followed features of biokinetics of the radioactive substances, determined the major route of their excretion, evaluated efficiency of surgical d-bridement and complexation medicine (pentacin). clinical and biophysicdata collected could serve to increase efficiency of urgent therapeutic and prophylactic measures aimed to individuals with wounds contaminated with radioactive substances.

Adult↗

PubMed1991

[Heterogeneity and polymorphism of the thymus hyperplasia syndrome in children in the first 3 years of life].

Sixteen years of observation over a large group of children with the syndrome of the enlarged thymus with the use of up-to-date methods of examining the CNS, immune, endocrine, neuroendocrine systems and the autopsy data allowed the heterogeneity and polymorphism of the given syndrome to be revealed. Both transitory and stable enlargement of the thymus may be observed. The syndrome of the stable-enlarged thymus is likely to be formed in the intrauterine period and postnatally as well. It may be associated and not associated with thymus-dependent immunodeficiency. The morphological investigation of the thymus may show an enlargement of the cortical area with enhanced T lymphocyte proliferation in it or formation of lymphoid follicles. In clinical practice, the syndrome of the stable-enlarged thymus should be differentiated with thymic tumor. The working classification of the syndrome and concept of the pathogenesis of the stable-enlarged thymus are offered.

Age Factors↗

PubMed1991

[T and B components of the immune system in acute bronchopulmonary diseases in children with thymomegaly and without it].

The immune status was estimated comprehensively and indicators of the level I and II tests of T and B components of the immunity system were defined in 120 children with thymomegaly (group I), in 30 children with unenlarged thymus (group II), and in 40 practically healthy children with unestablished size of the thymus, with a favourable family and personal disease history, who had never fallen ill before the immunologic examination (group III). The children belonging to groups I and II were examined at the acute disease period, during convalescence and clinical wellbeing. It has been established that during the acute bronchopulmonary disease, the group I and II children manifested the same regularities of immune response to the action of an antigenic stimulus. However, at the period of the clinical wellbeing, the group II children showed a higher lymphocytosis, impairment of the ratio of the T lymphocyte subpopulations, an increase of the EAC--RFC count, and a decline of the level of serum thymic factor. It is assumed that in the group I children, the system of immunologic defence is of weak safety within the first 3 years of life.

Acute Disease↗

PubMed1990

[New data on thymomegaly as a syndrome of congenital (primary) immunodeficiency].

Basing on a combined clinicomorphological investigation of the thymicolymphatic and neuroendocrine systems including measurements of blood thymic hormones and their levels in thymic tissue it is shown that congenital thymomegaly can be considered a dysfunction of the hypothalamo-hypophysial system. The dysfunction manifests with polyglandular endocrinopathy and congenital immunodeficiency related to the group of thymus-dependent immunodeficiencies. Thymomegaly is often coupled with congenital malformations.

Child, Preschool↗

PubMed1990

[The production of immunomodulating polypeptides by the thymus during its acute (accidental) involution in children].

The content of the thymalin polypeptides in the thymus is studied in the course of the 1st to 4th stages of the acute thymus involution in children dying from noninfectious and infectious disease. The results obtained were compared to the level of the circulating thymic factor and the number of T- and 'O' lymphocytes in the circulating blood of children with identical diseases and control group of the same age. It is concluded that the acute involution of the thymus in children with non-infectious and acute infectious diseases results in the progressive decrease of the production by the thymus of the immunomodulating polypeptides (thymic hormones) which is restored in the period of recovery.

Acute Disease↗

PubMed1986