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Biomedical subjects

L G Larsson

Publications and source records attributed to L G Larsson.

At least 91 records · Page 5Linked to original sources
PubMed1986

Smoking and lung cancer with special regard to type of smoking and type of cancer. A case-control study in north Sweden.

The aetiologic role of tobacco smoking was elucidated in a case-control study comprising 579 cases of male lung cancer registered during 1972-1977 in northern Sweden. The population aetiologic fraction attributable to smoking was about 80% in this series. Pipe smoking was as common as cigarette smoking and gave similar relative risk. The pipe smoking cases, however, had significantly higher mean age and mean smoking years at the time of diagnosis than the cigarette smoking cases. An obvious dose-response relation was found for both cigarette and pipe smoking. In ex-smokers, the relative risk gradually decreased from five years after cessation of smoking. This decrease was, however, much less pronounced in ex-pipe smokers than in ex-cigarette smokers. High relative risks were obtained for small cell and squamous cell carcinomas. For adenocarcinomas the relative risk was considerably lower but still significantly increased. Two types of controls were used, i.e. decreased and living. Comparison with living controls gave generally higher risk estimates than comparison with deceased controls.

Adenocarcinoma↗
PubMed1986

Mortality and cancer incidence among Swedish dock workers--a retrospective cohort study.

The study originates from the arousal of suspicions that, in connection with loading and unloading work involving the use of trucks, exposure to diesel exhaust fumes may be carcinogenic. This report describes a register study in which a broad mapping of the cause-of-death pattern and cancer morbidity has been carried out through the matching of locally compiled personal data with those from a central register, the Cause-of-Death Register, and the Cancer Register. The results obtained thus far show a low total mortality--irrespective of cause of death--but a tendency towards an excess risk for cancer morbidity, mainly due to lung cancer.

Humans↗
PubMed1985

Professional driving, smoking, and lung cancer: a case referent study.

In a case referent study of about 600 cases of male lung cancer in northern Sweden the risk in professional drivers was specifically studied. Data concerning occupations, time and type of employment, and smoking habits were collected by questionnaires directed to close relatives. On average, professional drivers were heavier smokers and this was the chief cause of a slightly increased crude risk ratio in the study as a whole. Smoking drivers in an upper age group (70 and over) had a high relative risk of lung cancer, whereas in a lower age group (under 70) no significant increase was found. The relative risk in non-smoking drivers in the upper age group was moderately raised with borderline statistical significance. The high relative risk estimated for smoking drivers in the upper age group suggests a synergistic effect between smoking and occupational exposure.

Adult↗
PubMed1985

Underground mining, smoking, and lung cancer: a case-control study in the iron ore municipalities in northern Sweden.

A case-control study of lung cancer in males was performed in two municipalities in northern Sweden with large iron ore mines. Previous studies had revealed an increased lung cancer risk for underground workers in these mines, with all probability related to radon daughter exposure. Data concerning underground mining and smoking were obtained from questionnaires. All analyses suggested an interaction of a multiplicative type between underground mining and smoking in the causation of lung cancer in this population. The calculated population etiologic fraction was about 45% for underground mining and about 80% for smoking.

Aged↗
PubMed1985

Acute febrile neutrophilic dermatosis (Sweet's syndrome). Successful treatment with short term corticosteroids.

Acute febrile neutrophilic dermatosis is a disease of unknown etiology characterized by fever, tender skin lesions, and arthritis. Histopathologic examination shows a perivasculitis of the skin with lack of inflammation of vessels. It occurs in a female: male ratio of 4:1 with middle age females affected most frequently. We report a 17-year-old male with acute febrile neutrophilic dermatosis in whom the relationship between the arthritis, skin eruptions, white blood cell count and erythrocyte sedimentation rate are presented. The young man was treated with prednisone for only 5 days with complete resolution of the signs and symptoms and without relapse for 11 months.

Acute Disease↗
PubMed1984

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria--an epidemiological investigation.

Some environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma (HCC), 15 cases of intrahepatic cholangiocellular carcinoma (CC), 3 cases of haemangiosarcoma and 1 case of unspecified sarcoma in the liver--102 cases in total. Two matched controls were used in each case. One case with haemangiosarcoma was exposed to polyvinyl chloride. The case with unspecified soft-tissue sarcoma was exposed to phenoxy acids. A 4-fold increase in the risk of HCC was seen in alcoholics, and regular drinking gave a 3-fold increase in the risk. Exposure to organic solvents gave a 2-fold increase in the risk of HCC. No increased risk was observed for cases exposed to various other chemicals. Three cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases with PLC had polyphyria cutanea tarda (PCT) which in 4 cases was related to alcoholism and in one case to haemochromatosis.

Acute Disease↗
PubMed1984

Occurrence of other malignancies in patients treated for basal cell carcinoma of the skin. A cohort study.

The patient with basal cell carcinoma of the skin has sometimes been thought to run an increased risk for developing other malignancies. A retrospective cohort study of 468 cases including about 4 400 person-years of observation did not reveal a significant deviation from expected values estimated either from cancer register data or from cancer incidence in matched controls.

Basal Cell Carcinoma↗
PubMed1982

Combined effects of mining and smoking in the causation of lung carcinoma. A case-control study in northern Sweden.

Within a case-control study of male lung carcinoma in northern Sweden combined effects of underground mining (iron ore mines) and smoking were analysed. A synergistic effect was found approximately of multiplicative type. Cases with lung carcinoma exposed to underground mining had a considerably lower average cumulative tobacco consumption than other lung carcinoma cases as an expression of the fact that smoking is particularly dangerous in underground miners. Small cell undifferentiated carcinoma was overrepresented among the cases exposed to underground mining and were especially often low tobacco consumers. In the 2 municipalities where the iron mines were located 74 per cent of the male lung carcinoma incidence could be explained by smoking and 55 per cent by underground mining (etiologic fractions).

Aged↗
PubMed1982

Interaction between underground mining and smoking in the causation of lung cancer: a study of nonuranium miners in northern Sweden.

Combined effects of underground mining (nonuranium mines) and smoking were analyzed in a case-control study of male lung cancer in northern Sweden. Lung cancer cases exposed to underground mining had a considerably lower average cumulative tobacco consumption than other lung cancer cases, indicating that smoking is especially dangerous for underground miners. When relative risks were estimated, a synergistic effect of multiplicative type was found between smoking and underground mining.

Humans↗