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L G Stark

Publications and source records attributed to L G Stark.

At least 55 records · Page 3Linked to original sources
PubMed1977

Undergraduate pharmacological training programs applicable to agricultural science majors.

Undergraduate training programs leading to degrees in pharmacology or toxicology do not exist on most university campuses. Agricultural science students who may ultimately use large quantities of herbicides, pesticides, and other agricultural products may obtain degrees without any exposure to the disciplines of pharmacology or toxicology; some reasons for this are discussed. The design and implementation of some courses suited to the qualifications of most undergraduate agricultural science majors are outlined. In general, a blend of lectures, discussions, and student presentations facilitates adequate presentation of the course material. Specific suggestions for student term projects are mentioned. Some of the available textbooks suitable for undergraduate courses of this type are very briefly discussed. It is suggested that in order to educate nonacademic users of agricultural chemicals, pharmacologists and toxicologists may have to work closely with both industry and those closer to the agricultural community such as county agricultural extension agents and farm youth organizations.

Agriculture↗
PubMedDate not supplied

Chlorinated hydrocarbon pesticides and amygdaloid kindling.

Previous studies by our laboratory have shown that exposures to either lindane or dieldrin enhanced the rate of acquisition of the fully kindled amygdaloid seizure in the rat. To examine whether this enhancement generalizes to all groups of chlorinated hydrocarbon pesticides, the effect of dichlorodiphenyltrichloroethane (DDT) or chlordecone (kepone) was examined on the acquisition rate of the kindled amygdaloid seizure in the rat. Daily DDT exposure (5, 10 or 20 mg/kg, PO) failed to modify the rate of acquisition of the kindled amygdaloid seizure despite resulting in tremors in many of the rats in the high dose group. A single high dose of kepone (50 mg/kg) which resulted in up to 9 days of tremors and weight loss in the treated animals, also failed to modify the rate of kindling acquisition. These data demonstrate that not all CNS active chlorinated hydrocarbon pesticide exposures result in enhancement of kindling acquisition. The kindled amygdaloid seizure model of epilepsy appears to differentiate between the neurotoxic consequences of chlorinated hydrocarbon pesticides that cause myoclonus and seizures (e.g., lindane and dieldrin) and those that primarily cause tremors (DDT and kepone).

Amygdala↗