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Biomedical subjects

L G Wheaton

Publications and source records attributed to L G Wheaton.

27 records · Page 2Linked to original sources
PubMed1979

Relationship of seminal volume to size and disease of the prostate in the beagle.

The seminal volume of young adult Beagles was correlated with the size of and disease in their prostates. The ejaculate volume of naturally collected semen increased in a linear manner with prostatic weight in dogs with normal or glandular hyperplastic prostates. This correlation was not observed in the dogs with cystic hyperplasia, in which there was a reduction in volume of 50% in the semen produced for each gram of prostate. There were no significant differences in other seminal characteristics regardless of prostatic size of disease.

Animals↗
PubMedDate not supplied

Total colectomy with ileorectal anastomosis in the cat.

Total colectomy with end-to-end ileorectal anastomosis was performed in eight healthy adult cats. Hydration status, body weight, attitude, appetite, and stool consistency were monitored for 24 weeks. Ileal water absorption was determined at weeks 1, 6, 12, 18, and 24 using the double-lumen catheter intestinal perfusion technique with polyethylene glycol as the indicator substance. Bowel adaptation was evaluated by histologic morphometric analysis of full-thickness ileal biopsies taken at the time of total colectomy and at weeks 6, 12, 18, and 24. The anastomoses were examined at necropsy for evidence of leakage and development of strictures. All cats resumed normal activity in 48 hours and maintained or gained weight during the study. Small volumes of watery diarrhea were present immediately after surgery, but by week 1 all cats had a semi-solid nonformed stool. At month 2, three cats developed semi-solid formed stools. One cat had occasional perineal soiling and five cats had at least one episode of hematochezia. There was improvement in ileal water absorption in two cats, and there were significant increases in villus height, enterocyte height, and enterocyte density in all cats. Results of postmortem examination of the anastomosis showed no evidence of stricture in any cat.

Adaptation, Physiological↗
PubMedDate not supplied

Postoperative catecholamine response to onychectomy in isoflurane-anesthetized cats. Effects of analgesics.

Twenty-four healthy adult cats were anesthetized with isoflurane in oxygen. Six cats (group 1) served as controls; onychectomy of the forefeet was performed in the other three groups. Saline was administered intravenously to group 1, and morphine, xylazine, and salicylate were administered to groups 2, 3, and 4, respectively. Mixed venous blood samples were drawn for catecholamine analysis before induction of anesthesia, after recovery from anesthesia, and 30 minutes and 60 minutes after administration of the analgesic agent. Plasma catecholamine concentrations were determined by high performance liquid chromatography. Isoflurane anesthesia alone induced a transient increase in epinephrine concentration. Norepinephrine and epinephrine concentrations increased significantly after onychectomy. Morphine and xylazine significantly decreased postoperative norepinephrine and epinephrine concentrations; salicylate did not.

Analgesics↗
PubMedDate not supplied

Evaluation of canine-derived fibrin sealant as a hemostatic agent.

The purpose of this study was to determine whether canine-derived fibrinogen concentrate applied with bovine thrombin was a safe and effective topical hemostatic agent. A canine liver biopsy model was selected to test this product. Cryoprecipitate was prepared from frozen canine plasma using two freeze/thaw/centrifugation cycles. Six healthy adult dogs (weighing more than 18 kg) were used in the fibrin sealant study, and an additional three dogs were used as controls for the liver biopsy. A 1 x 3 cm liver biopsy specimen was obtained, digital pressure was applied to reduce bleeding, and the fibrinogen concentrate was immediately sprayed on the bleeding surface simultaneously with bovine thrombin (1,000 IU/mL). The mean +/- standard error of the mean (SEM) blood pressure at time of biopsy was 98 +/- 9 mm Hg, and the rate of hemorrhage from the cut liver edge was 8.0 +/- 1.1 mL/min. The total blood loss during fibrin sealant application was 37 +/- 9 mL and total time for hemostasis was 5.5 +/- 1.3 minutes. There was no additional hemorrhage after application of the fibrin sealant. In the three control dogs, fibrin sealant was not applied and only digital compression was used to decrease hemorrhage. Before digital compression, the rate of hemorrhage from the cut liver edge was 13.1 +/- 3.1 mL/min. Bleeding had not stopped after 10 minutes of compression and the mean postcompression rate of hemorrhage was 4.0 +/- 2.6 mL/min. Signs of secondary bleeding after fibrin sealant was applied were not evident during the immediate postoperative period or over the next 14 days.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Hematometra secondary to anticoagulant rodenticide toxicity.

An adult, intact female Australian shepherd presented for frank vaginal bleeding of unknown duration. The only coagulation profile abnormality upon presentation was mild prolongation of the partial thromboplastin time (PTT). The uterus was removed at surgery and contained a large amount of coagulated blood. Clotting profiles were markedly abnormal 48 hours postoperatively. Serum analysis was positive for brodifacoum, an anticoagulant rodenticide. Preoperative coagulation was most likely normalized by vitamin K1 therapy administered prior to presentation. The only manifestation of anticoagulant rodenticide was hematometra. Rodenticide intoxication should be considered in the differential diagnosis list of hematometra or metrorrhagia.

4-Hydroxycoumarins↗