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Biomedical subjects

L Gärtner

Publications and source records attributed to L Gärtner.

At least 19 recordsLinked to original sources
PubMed1988

[Hantaan virus infections as a cause of acute kidney failure. 3 cases in West Germany].

Three cases of Hantaan virus infection (Korean haemorrhagic fever) leading to acute renal failure are described. All three had mild haemorrhagic fever with a renal syndrome. It had started with acute fever followed by oliguria, proteinuria and microhaematuria (in two patients) in the further course of the disease, as well as urea and creatinine retention. One patient needed to be dialysed twice. Hantaan virus-specific IgG antibodies were demonstrated in all three patients; one also had IgM antibodies.

Acute Kidney Injury↗
PubMed1985

[Herpes simplex virus infections].

There are two serological types of herpes simplex virus, HSV-1 and HSV-2. The types can be differentiated by different methods. After a primary infection HSV reaches the sensory ganglions by the way of peripheral nervous tracts. The virus remains for life in the ganglion as virus genome. After activation and return movement a new infection can appear. A lot of various diseases are caused by primary infection, reactivation or reinfection. The diagnosis in herpes virus diseases includes the detection of virus or viral antigens and the demonstration of specific antibodies against HSV. Effective antiviral drugs are available for chemotherapy of HSV-infection. Acyclovir is a beneficial drug without toxic secondary effects. The prevalence of HSV-antibodies in the population is very high.

Antiviral Agents↗
PubMed1985

[Serologic diagnosis of primary cytomegalovirus infections in patients following kidney transplantation using the indirect immunofluorescence technic and the complement-fixation test].

Sera of 22 recipients of kidney transplants with clinically and serologically (complement binding reaction) ascertained cytomegalovirus infection were retrospectively examined for virus-specific antibodies of the class IgM by means of the indirect immunofluorescence test. Already two to five days after the appearance of the adequate clinical symptoms (leucopenia, fever, T-lymphocytopenia, increase of creatinine and thrombocytopenia) CMV-IgM-antibodies could be proved. On average a positive complement binding reaction was found only two weeks later. In other 13 patients of the actual control programme the CMV-IgM-antibody findings first obtained were compared with the results of the complement fixing reaction obtained later. Neither falsely positive nor falsely negative results could be found.

Antibodies, Viral↗
PubMed1984

Antibodies to cytomegalovirus-induced pre-early nuclear antigen in the anticomplement-immunofluorescent test in comparison to IgG and IgM antibodies in the indirect and direct enzyme-linked immunosorbent assay in diagnosing cytomegalovirus infections.

Development of antibody to pre-early nuclear antigen (anti-PENA) in persons with primary cytomegalovirus (CMV) infection was tested in serial serum specimens of four renal transplant patients and four patients undergoing open heart surgery using the anticomplement-immunofluorescent test (ACIF). In patients undergoing open heart surgery seroconversion of anti-PENA was mostly concomitant with the rise of IgG or IgM antibodies determined in the indirect or direct enzyme-linked immunosorbent assay (ELISA) whereas in all renal transplant patients developing anti-PENA a delayed rise of this antibody compared to IgG and IgM antibodies was observed. Significant rise of anti-PENA accompanied by an increase of IgG and IgM antibodies in indirect and direct ELISA was also found in three patients undergoing open heart surgery with recurrent CMV-infection. Anti-PENA was shown to persist longer than IgM antibody. Moreover, anti-PENA was present in the serum of nearly two-thirds of 30 persons with IgG antibody but without IgM antibody. It is concluded that antibody determination to PENA can serve as an additional means of diagnosing primary and recurrent CMV infections. Because of its long persistence only seroconversion or significant rise of this antibody may be considered evidence of infection. In some patients a delayed development of anti-PENA must be taken into consideration.

Adult↗
PubMed1983

Persistence of IgM antibodies to cytomegalovirus-induced late antigen in pregnancy and postpartum.

21 women with IgM antibodies to cytomegalovirus-induced late antigen (CMV LA) as determined in the first, second or third trimester were tested for the persistence of these antibodies during pregnancy and postpartum. Out of 21 women 16 still showed IgM antibodies against CMV LA by 6-9 months after delivery. No striking differences could be found between women with primary or recurrent CMV infections as well as those who had intrauterine infection.

Antibodies, Viral↗
PubMed1983

Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, tonsillar carcinoma and control groups.

In the sera of 17 patients with nasopharyngeal carcinoma (NPC) and of 19 patients with tonsillar carcinoma (TC) the titres of IgA, IgG and IgM antibodies to EBV VCA (viral capsid antigen) and of IgG antibodies to EBV EA (early antigen) were determined by the indirect immunofluorescence (IF) method. Significant difference was observed in the frequency of IgA antibodies to EBV VCA and IgG antibodies to EBV EA between NPC patients and controls. There was also a significant difference between the frequency of IgM antibody to EBV VCA and EBV EA antibody titres in TC patients and controls. The geometric mean titre (GMT) of IgG antibodies to EBV VCA was significantly higher in the NPC and TC patients as compared to controls.

Adult↗
PubMed1982

In vitro stimulation of lymphocytes by different strains of cytomegalovirus.

The in vitro stimulation of lymphocytes from 15 healty adult donors by 5 different stains of CMV resulted in a positive stimulation ratio of lymphocytes from CMV seropositive donors with each of the 5 different strains. Differences in the absolute strength of the response was observed among the 5 strains for each individual, but we concluded that the use of antigen prepared with 1 strain of CMV is sufficient to obtain a positive or negative result. A maximum value for the in vitro lymphocyte stimulation test, however, will only be obtained using different antigen concentrations from several different CMV strains simultaneously.

Antigens, Viral↗
PubMed1981

[IgM antibodies against cytomegalovirus in pregnancy and incidence of intrauterine infections in pregnant women with positive IgM antibody reaction (author's transl)].

In 47 of 620 pregnant women (7.6%) examined during the first, second and third trimester, it was possible to identify IgM, antibodies against late antigen (LA) of the cytomegalovirus during one or several examinations. 6 of 37 examined children of mothers with positive IgM antibody reaction were found to have intrauterine infection, although there had been no clinical signs of an infection at the time of delivery. All 6 children with intrauterine infection were from 32 mothers (18.8%) with IgM antibodies during the first trimesters. The IgM antibodies of the mothers with children having intrauterine infection did not differ fundamentally from the IgM antibody levels of the mothers with non-infected children with regard to titration value and persistency.

Adolescent↗
PubMed1980

[Immunostaging of patients with chronic pancreatitis. I. A study of humoral and cell-mediated immunity (author's transl)].

Immunostaging was performed in patients with chronic pancreatitis of different etiologic groups. Immune responifveness was assessed by immunoglobulin serum levels, non specific autoantibody formation, C3 levels, antistreptolysin reaction, antibody titer against Toxoplasma gondii, E. coli, Herpes simplex-, Mumps- and Cytomegalovirus and screening for soluble immune-complexes (PEG precipitation assay), number of T- and B-lymphocytes, lymphocyte responsiveness to PHA, PPD, tetatoxoid and mumps-antigen in a whole blood assay, skin testing with candidin, trichophytin, tuberculin and streptokinase and HLA-typing. In some cases we found a depressed cell-mediated immune responsiveness. Patients were divided into two groups based on this main finding. Cellular hyporesponsiveness was correlated to the severity of the disease and a high incidence of HLA-B5 but not to any etiologic factor of the disease.

Adult↗