PubMed Health⌕ Search

Biomedical subjects

L GRODSKY

Publications and source records attributed to L GRODSKY.

14 recordsLinked to original sources
PubMed1961

Transitional cell cancer of the anus and rectum.

A study was made of all cases of transitional cell cancer of the anus or rectum in the records of the University of California Medical Center, San Francisco. None was listed until 1945, then an additional seven between 1954 and 1960. During the latter period there were 192 cases of adenocarcinoma of the rectum, six cases of squamous cell or epidermoid rectal cancer and 12 cases of squamous cell cancer of the anus.Distinctive and highly malignant anal and rectal epithelial tumors will occasionally arise at or near the anorectal junction from inconstant embryologic entodermal cloacal vestiges. These atypical nonkeratinizing lesions are very similar microscopically to transitional cell tumors found in the cloacogenic portions of the lower genitourinary tract. Review of the literature indicates that the prognosis of cloacogenic anal and rectal lesions appears to be relatively graver than that for the more common adenocarcinomas and keratinizing squamous cell epitheliomas. Early diagnosis and prompt, radical excision seem to offer the only hope for survival.

Adenocarcinoma↗
PubMed1959

Common anorectal complications in pregnancy. Methods of management.

The hormonal, anatomic and pelvic vascular changes of pregnancy have a profound effect on the anorectum, making hemorrhoidal disease the most common anorectal complication of pregnancy. Anal infections such as fissures, abscesses and fistulas are relatively infrequent.Physiologic engorgement of the hemorrhoidal vessels during pregnancy is quite common, transitory and requires only simple palliation. True symptomatic hemorrhoidal disease, however, is less common, more permanent and will usually need corrective treatment to prevent immediate complications and future aggravation. Serious rectal and colonic diagnostic problems demand endoscopic investigation regardless of the pregnancy. Clinical experience and studies seem to indicate that extreme conservatism in the treatment of severe complicated hemorrhoidal disease during pregnancy appears to be unwarranted. After consultation and agreement, surgical treatment of severe, disabling, symptomatic hemorrhoids that are not responsive to palliation can be safely accomplished during the second trimester of pregnancy. Once true hemorrhoidal disease develops, correction should be done before a subsequent pregnancy to avoid later increased aggravation and morbidity.

Abscess↗
PubMed1956

Leukoplakia of the anus.

Anal leukoplakia is catalogued as precancerous because of the high incidence of malignant transformation found in lesions of this type.Biopsy must be done to substantiate the clinical diagnosis of leukoplakia, to demonstrate the stage of the process, and to indicate the proper effective therapeutic approach. Surgical excision is advisable in the early stage to avoid later carcinomatous changes and mutilating operations necessary for advanced malignant growth. Three cases of leukoplakia involving the anoderm of the anal canal are presented herewith.

Anal Canal↗