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Biomedical subjects

L Gage-White

Publications and source records attributed to L Gage-White.

6 recordsLinked to original sources
PubMed1998

Practical environmental modifications for the inhalant allergy patient.

Environmental management of inhalant allergens is an important part of a comprehensive allergy management program and is the most controllable aspect by the patient. The safest and most effective way to eliminate an allergic reaction is to eliminate exposure to the antigen that provokes the response. The basic control principles for all inhalant allergens are to (1) remove the source of the allergen if possible, (2) remove accumulated allergen, and (3) prevent the return of the allergen. This article examines the published evidence for environmental control measures in terms of effectiveness, cost, and ease of implementation.

Air Pollutants↗
PubMed1989

Perichondrial cutaneous graft. An alternative in composite skin grafting.

The perichondrial cutaneous graft (PCCG) is a composite skin graft that is an alternative to the full-thickness skin graft (FTSG). The PCCG is harvested from the ear and contains epidermis, dermis, scant subcutaneous tissue, and the perichondrial layer. This experiment examined the differences in contraction properties of PCCGs and FTSGs. Twenty FTSGs and 20 PCCGs were harvested from the ears and grafted onto the backs of seven New Zealand white rabbits. The results confirmed that the PCCG provides superior coverage to the FTSGs with regard to thickness, contraction properties, and hair retention. This graft has potential in reconstructive head and neck surgery. When skin grafting is appropriate, the PCCG may provide superior results.

Animals↗
PubMed1988

Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs.

Two side effects which limit the use of cisplatin in cancer chemotherapy are severe nephrotoxicity and ototoxicity. The concurrent administration of sodium thiosulfate with cisplatin reportedly protects from cisplatin nephrotoxicity, however, protection from ototoxicity has not been documented. The purpose of this study was to examine the efficacy of using thiosulfate to ameliorate the ototoxic effects of cisplatin. Toward this end, the effects of cisplatin alone, cisplatin administered concurrently with sodium thiosulfate (CIS/THIO), and sodium thiosulfate alone on the auditory brainstem response (ABR) of guinea pigs were compared. ABR waveforms, comparing latencies, amplitudes and response thresholds, were monitored before, immediately after, and 30 days post treatment. Sodium thiosulfate administered with cisplatin (CIS/THIO) consistently protected animals from hearing loss and surprisingly yielded significant increases in amplitude when compared to baseline and saline controls. However, ABRs of CIS/THIO animals returned toward baseline values after 30 days.

Animals↗
PubMed1988

Frontal sinus fractures: some problems and some solutions.

Head trauma can result in serious injuries leading to life-threatening situations. Often accompanying these injuries are fractures involving the frontal sinus. Some fractures are subtle and difficult to diagnose, while others are massive and difficult to treat. The experience at this institution in the management of frontal sinus fractures is examined. Particular emphasis is placed on the problematic cases. These include fractures that were nearly overlooked, those that were associated with massive CSF leaks, and those which were extensively comminuted. In treating some of the most severe compound injuries, a frontalis myofascial flap has been used successfully to "plug" the site of CSF leakage. The review will include the types of fractures encountered, associated injuries, errors in diagnosis, the treatment rendered, and the complications which resulted. As encountered in other studies relating to trauma, adequate follow-up has been a serious shortcoming. The protocol presently used in the management of these injuries will be outlined.

Adolescent↗
PubMed1988

Incidence of Zenker's diverticulum with hiatus hernia.

The concomitant occurrence of Zenker's diverticulum and hiatus hernia in several patients prompted an investigation to determine whether there is a statistically significant increased incidence of hiatus hernia in patients with Zenker's diverticulum. Radiologic reports contained in 104 charts of patients from the University of Iowa with a diagnosis of Zenker's diverticulum were analyzed retrospectively for the presence of hiatus hernia. Radiologic reports contained in charts of a control group of patients, who had a barium swallow for work-up of a head and neck malignancy, were also analyzed. The control group had a 16% incidence of hiatus hernia, which was consistent with published data. The Zenker's diverticulum group had a 39% incidence of hiatus hernia, a statistically significant increase over the control group. The pathophysiology linking these conditions and the clinical implications of their relationship are discussed.

Adult↗