Biomedical subjects

L Gamra

Publications and source records attributed to L Gamra.

6 recordsLinked to original sources

PubMed2006

[Carcinosarcoma of the skin].

BACKGROUND: Carcinosarcoma of skin is a biphasic tumor composed of intimately admixed malignant epithelial and mesenchymal components. Various terms have been used to designate these tumors (metaplastic carcinoma, pseudosarcoma, spindle cell carcinoma, etc.). However, the histogenetic conception has changed and carcinosarcoma is currently regarded as authentic sarcomatoid carcinoma. CASE REPORT: The authors report the case of a 32-year-old women initially presenting with a budding and ulcerating tumor at the site of an old cutaneous scar on the right leg. Histopathological and immunohistochemical evaluation led to a diagnosis of cutaneous carcinosarcoma. One month after treatment, the patient developed inguinal lymph node metastasis. DISCUSSION: Our case and a review of other cases in the literature confirm the dual epithelial and sarcomatous phenotype of sarcomatoid carcinoma. Progressive transition between the cells of the two components on microscopic analysis and their positive immunostaining for anti-p53 antibody suggest a clonal origin of the tumor. The carcinomatous component seems to influence the course of the disease with the development of metastases, particularly at the lymph nodes. It thus seems advisable to combine lymphadenectomy with surgical tumor excision.

Adult↗

PubMed2005

[Uterine carcinosarcoma in a teenager: report of a case macroscopically mimicking rhabdomyosarcoma].

Uterine carcinosarcoma (malignant mixed mullerian tumor) is uncommon. We report the case of a 17-year-old patient who complained of pelvic pain and abnormal genital bleeding, and had a voluminous hemorrhagic tumor protruding through the vaginal os. Hysterectomy was performed. The histopathologic and immunohistochemical evaluation led to the diagnosis of uterine carcinosarcoma. Adjuvant chemotherapy was given. In spite of the surgical treatment, the evolution was fatal with widespread metastases. From data of the literature, we discuss the diagnosis, histogenesis and treatment of this rare tumor.

Adolescent↗

PubMed2004

[Diagnostic problems associated with intestinal amoeboma: case report].

Amoeboma is an inflammatory mass of the colon. It is uncommon with most cases occurring in Latin America and South Africa. When amoeboma is the presenting symptom of amoebiasis, it poses the problem of differential diagnosis of colon cancer. This report describes the case of a 60-year-old patient who presented a painful mass in the left hypochondrium. Radiologic and endoscopic examinations depicted a ring-like stenosis of the transverse colon in association with a mesenteric reaction. The presumptive diagnosis was colon cancer and the patient was referred to the National Oncology Institute for surgical treatment. Histological examination of the surgical specimen after segmental colectomy confirmed diagnosis of intestinal amoeboma. The patient was treated medically using metronidazole. Since intestinal amoebiasis is common in our country, amoeboma must be considered as a rare but potential diagnosis in patients presenting masses of the colon. Differential diagnosis of carcinoma is necessary to avoid the risks associated with unnecessary surgery.

Amebiasis↗

PubMed2002

[Pelvic actinomycosis simulating adnexal malignant tumor].

The purpose of this report is to describe the case of a 35-year-old patient admitted to the National Oncology Institute in Rabat, Morocco for pelvic pain and deteriorating general status ongoing for 8 months. Clinical and ultrasonographic examination showed a heterogenous mass measuring 7 cm in maximum width located inferior and lateral to the inferior aspect of the right side of the uterus. These findings were suggestive of a malignant tumor of the right ovary. Ovariectomy and omentectomy were performed. Histological examination of surgical specimens demonstrated right tubo-ovarian actinomycosis associated with peritonitis. Genital tract actinomycosis is an uncommon finding in women of childbearing age. It is due to colonization by a pyogenic bacteria (Actinomyces) usually secondary to a gastrointestinal infection, e.g. ileocecum, and sometimes in association with the presence of an intrauterine device or foreign body. Based on this case report, the authors discuss abdominopelvic actinomyocosis with emphasis on tumor-like findings that can lead to misdiagnosis by clinicians and radiologists.

Actinomycosis↗

PubMed1997

[Leiomyosarcoma of the vagina: a rare case].

Vaginal leiomyosarcoma is unfrequent. We report on a case in a 50-year-old multipara patient who had presented a posterior vaginal swelling since 6 months. The tumor was discovered at the occasion of pains and non hemorragic discharge. The histological pattern of the tumor was well-differentiated spindle cell sarcoma with pleiomorphic areas. The immunohistochemistry confirmed the smooth myogenic differentiation. The treatment consisted of posterior pelvic exenteration extended to the vagina. The patient is alive and free of disease at 20 months of fellow-up.

Female↗

PubMed1996

[A rare cause of retroperitoneal fibrosis: actinomycosis].

The authors report a case of retroperitoneal fibrosis secondary to actinomycosis with consequences on the urinary tract. They insist on the difficulty of diagnostic, the antibiotic's sensibility and the evolution towards fibrosis which can lead to renal function deterioration.

Abdominal Abscess↗