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Biomedical subjects

L Garbe

Publications and source records attributed to L Garbe.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Extrapancreatic hypoglycemic tumors. Apropos of a case of pleural fibrosarcoma].

The authors report a case of pleural fibrosarcoma associated with severe hypoglycaemia. Chromatography of the patient's serum and tumour fragments revealed a substance with a high molecular weight and an insulin-like activity. Professor Poffengarger's laboratory identified this substance as Non Suppressible Insulin-Like Protein or NSILAp which induces insulin-like effects on various tissues. A review of the literature is presented in the light of this case.

Adult↗
PubMed1992

[Post-traumatic osteolysis of the distal extremity of the clavicle. Anatomopathological study of 2 cases].

Two patients with post-traumatic osteolysis of the distal end of the clavicle undergoing surgery 5 months and 22 months respectively after the initial trauma were evaluated histopathologically. The lysed zone was replaced by tissue of fibrous appearance, with little blood supply and non-inflammatory, the presence of which could be suspected by magnetic resonance. The synovial membrane, non-inflammatory but hypervascularised, participated in the process but did not appear to be directly responsible for the osteolysis. The osseous tissue of the patient, operated upon early, showed signs of osteoclastic resorption but there was neither stasis, vasodilatation nor signs of osteogenesis. These various findings suggest that post-traumatic osteolysis of the distal end of the clavicle does not result from local ischemic events. These appearances seem identical to those described in multifocal primary osteolysis, the cause of which also remains unknown.

Adult↗
PubMed1991

[Respiratory failure in a HIV seropositive heroin addict female].

A 31-year-old woman, heroin addict since ten years, and infected by the human immunodeficiency virus (HIV) since one year, was admitted to the intensive care unit for respiratory failure (PaO2 = 40 mmHg and PaCO2 = 14.8 mmHg, despite breathing pure oxygen). She had been followed up for 6 months for increasing dyspnoea due to chronic cor pulmonale for which no satisfactory explanation had been put forward. Artificial ventilation with 8 cmH2O positive end-expiratory pressure and 100% oxygen was completely inefficient. She died within a few hours. Postmortem lung biopsy revealed talc particles within interalveolar walls and alveolar macrophages as well as the expected alterations in blood vessels. Pulmonary hypertension due to talc microemboli is a well-known cause of respiratory failure in heroin addicts. Such a diagnosis should not be overlooked in a patient infected with HIV. Respiratory failure may not be only due to opportunist infections, or tumours related to the HIV infection.

Adult↗
PubMed1991

Malignant transformation of an osteoblastoma of the skull: an exceptional occurrence. Case report.

What is apparently the first reported case of spontaneous malignant transformation of a benign osteoblastoma of the skull is described. The initial lesion was completely removed surgically and showed the histological features typical of a benign osteoblastoma. No radiotherapy was performed. Eleven years later the patient developed an osteosarcoma of the skull. Review of the literature showed that malignant transformation of benign osteoblastomas is extremely rare and could take place spontaneously. However, the risk of this occurring seems higher after inadequate initial treatment (curettage or partial excision). Follow-up monitoring of patients with osteoblastoma of the cranial vault is suggested.

Adult↗
PubMed1991

[Pulmonary hypertension secondary to talc microemboli in a HIV seropositive heroin-addict woman].

Severe pulmonary hypertension presenting as acute cor pulmonare was observed in a HIV positive heroin addict. The usual aetiological investigations were negative. The apparently primary pulmonary hypertension was resistant oxygen and vasodilator therapy and was fatal in 6 months. Anatomopathological examination revealed the presence of talc microemboli in the pulmonary arterioles, severe medial hypertrophy and fibrous subendothelial thickening. The presence of the talc suggests that the pulmonary hypertension in this case was due to obstruction of the pulmonary vascular bed by the obstructive arterial lesions, despite the context of HIV infection.

Adult↗
PubMed1990

Primary intracerebral plasma cell granuloma: a light, immunocytochemical, and ultrastructural study of one case.

A case of primary intracerebral plasma cell granuloma without meningeal attachment is presented. Histologically, the lesion showed two different patterns. At the center, it displayed the features of a benign fibrous histiocytoma. At the periphery, a mixture of polyclonal plasma cells, lymphocytes, and "epithelial-like" cells was observed. Electron microscopy and immunocytochemistry confirmed the histiocytic nature of the "epithelial-like cells." The differential diagnosis and histogenesis of such a lesion are discussed.

Brain Diseases↗
PubMed1990

[Pleural fibroma: apropos of a case].

The authors report a case of a pleural fibroma occurring in a 72 year old woman. The tumour presented with both an osteoarthropathy and hypoglycaemia. An X-ray revealed an abundant associated pleural effusion. Immune studies were positive for the presence of vimentin and negative for keratin, as occurred in this case, were in favour of a pure fibroblastic origin for these tumours.

Aged↗
PubMed1990

[Plasma cell granuloma. Report of a case].

The authors report a case of plasma cell granuloma of the lung, an inflammatory tumour occurring in a young Egyptian aged 23 without any history of chest diseases. The patient had had three weeks before his hospital admission light haemoptysis and associated with weight loss. The diagnosis was made on a bronchial biopsy. Thus a diagnosis could be made without recourse to surgery because of the occurrence of bronchial invasion. No aetiological factor was found to explain the pathogenesis of the granuloma.

Adult↗
PubMed1988

Sensitization to aluminium by aluminium-precipitated dust and pollen extracts.

We report 2 cases of aluminium sensitivity in adults. Each time, the means of sensitization was the inoculation of aluminium-precipitated pollen or dust extracts for hyposensitization. We conclude that aluminium allergy is not exceptional and that in these cases one can observe allergic reactions to the Finn Chamber tests.

Adult↗
PubMed1987

[Pulmonary localization of Kaposi's sarcoma].

The authors describe a case of a 61 year old man suffering from Kaposi's sarcoma with pulmonary involvement associated with a hairy cell leukaemia. The numerous associations with Kaposi's sarcoma are reviewed and the circumstances of the unexpected appearance of this disease, placing it in the group of opportunistic diseases. The prognosis is totally different according to whether it is an isolated Kaposi's sarcoma without visceral localisation or to a form with polyvisceral involvement and associated with another neoplasm or immunodepression.

Humans↗
PubMed1986

Appearance of specific antibody-bearing cells in human bronchial mucosa after local immunization with bacterial vaccine.

The immune response to local in vivo inhalation of a lysed bacteria vaccine was assessed in surgical specimens of main-stem bronchi from patients who had undergone pneumectomy for cancer. The patient population included 22 subjects; 11 of these received the aerosol vaccine twice a day for 10 days prior to surgery, while the remaining 11 patients were used as controls and were not immunized. The submucous glands of immunized subjects showed significantly more cells than did those of the controls, i.e., 62 +/- 8 versus 37 +/- 7, respectively (P less than 0.05). The following five antigens were chosen for study by fluorescence assay: Streptococcus pneumoniae types II and III, Haemophilus influenzae, Streptococcus sp. strain D19, and Klebsiella pneumoniae. An immunization-dependent correlation was found between immunoglobulin A, immunoglobulin A-bearing cells, and specific antibody-bearing cells on the one hand and three of the five antigens (S. pneumoniae types II and III and Streptococcus sp. strain D19) on the other hand. This is the first time that a relationship has been established between bacterial immunization of the lower respiratory tract and local immunoglobulin production in humans.

Adolescent↗
PubMed1982

Treatment of tracheobronchial lesions by laser photoresection.

One hundred eleven patients underwent 205 laser photo-irradiation treatments using a Neodynium YAG laser with a flexible bronchoscope or an open tube for various tracheobronchial conditions, such as obstructing bronchogenic carcinomas, bronchial adenomas, and postintubation tracheal stenosis. The procedure was performed with either local or general anesthesia. Results were especially rewarding with endobronchial tumors. Tracheal stenoses were best treated by a combination of laser surgery and tracheal dilatation. No complication was encountered. Specific indications suggested for laser surgery are resection of inoperable tracheobronchial tumors, correction of tracheal stenosis, removal of surgical sutures, retrieval of tissue-embedded foreign bodies, and cauterization of hemorrhaging endobronchial tissues.

Adolescent↗
PubMed1981

[Immunofluorescence of the synovial membrane. Study of 100 cases].

A study of the use of immunofluorescence of synovial membranes in one hundred cases of various arthropathies reveals the value of the cytoplasmic localization of immune deposits and their type (Ig) in orienting the diagnosis, the influence of therapy, the lack of correlation with optical anatomopathology of synovial tissue (performed on another tissue fragment). Certain recurrent images such as fluorescence of blood vessel walls or the presence of fibrin are of little interest; other such as the cytoplasmic fluorescence of infiltrating cells and particularly, IgG-IgM mixed cellular fluorescence or coupled fluorescence-cellular with Ig and interstitial granular with Ig and C3 orientate the diagnosis to RA. Immunofluorescence appears to be of interest for inflammatory monoarthritis and probable RA. It is less interesting when the etiological context is limited. In addition, a negative immunofluorescent study does not rule out any diagnosis.

Arthritis, Rheumatoid↗