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Biomedical subjects

L García García

Publications and source records attributed to L García García.

16 recordsLinked to original sources
PubMed2001

[Long-term effect of angiotensin-converting inhibitors in children with proteinuria].

BACKGROUND: Prolonged proteinuria is a risk factor for renal damage. Angiotensin-converting enzyme (ACE) inhibitors can reduce proteinuria in adults with different types of nephropathy. PATIENTS AND METHODS: We evaluated treatment with low doses of ACE inhibitors (captopril and enalapril) in nine children with proteinuria due to chronic glomerular nephropathy. The patients' diagnoses were Henoch-Schönlein nephropathy, Berger's disease, Alport's disease, and chronic glomerulonephritis (GN) (membranous GN, focal and segmental GN, and membranoproliferative GN). None of the patients were receiving concomitant treatment. Those who had received corticoids, immunosuppressive or hypotensive drugs during the previous 3 months were excluded. The medication was administered over a prolonged period (mean 26.6 6.36 months). RESULTS: Proteinuria was initially in the nephrotic range (M = 55.34 10.44 mg/m2/h). In all patients concentrations fell significantly after 6 months and at the end of the treatment(p = 0.01 and p = 0.05). No adverse reactions to the medication were observed. The decrease in glomerular filtration rate was not significant. No significant changes in arterial pressure were found during treatment. CONCLUSIONS: ACE inhibitors could be an effective alternative for reducing proteinuria in children with prolonged nephropathy. These inhibitors do not produce the adverse effects associated with other drugs and can therefore be used for long periods.

Adolescent↗
PubMed1998

[Risk of transmission of Trypanosoma cruzi by blood transfusion in Mexico].

Data from the late eighties indicate that 1.6% of the Mexican population was infected with Chagas' disease and that transmission by way of blood transfusion was taking place in nearly every state, in areas of different sizes. The risk of transmission via that route has seldom been documented in Mexico, and for this reason a sentinel survey was conducted in 1994 in 18 blood banks belonging to the Ministry of Health and located in various states. The purpose of the study was to determine the risk of transmission via blood transfusion and to calculate the national prevalence of infection among potential donors, so as to have a set of general indicators of the prevailing disease burden and of the importance of this transmission route. Participants were selected on the basis of operating criteria: all government-run transfusion centers with the capacity to screen blood donors for at least one year and persons seeking to donate blood (n = 64,969) who satisfied the Official Mexican Standards (Norma Official Mexicana) for the therapeutic use of human blood and blood products. For the analysis of the results the centers were grouped according to migration flow in order to detect any possible influence the latter may have had on Chagas' disease transmission within the country. Screening was done with indirect hemagglutination using a reagent produced by the Instituto Nacional de Diagnóstico y Referencia Epidemiológicos and donated to the blood banks. Positive cases were confirmed by indirect immunofluorescence. Positive results were detected in 996 persons, for a prevalence of 1.5% (95% CI: 1.44 to 1.63). Concordance between the final results obtained by local labs and by the central lab was given by a kappa index of 0.87 (95% CI: 0.862 to 0.877). Cities having the highest emigration rates had three times the risk of transmission as compared to cities that drew immigrants (odds ratio = 2.82; 95% CI: 2.18 to 3.65). We recommend that mandatory serologic screening be enforced throughout Mexico, since migration makes it difficult to determine which areas are endemic.

Animals↗
PubMed1997

Treatment of superior and inferior vena cava syndromes of malignant cause with Wallstent catheter placed percutaneously.

Superior vena cava syndrome (SVCS) and inferior vena cava syndrome (IVCS) represent a severe symptomatic complication of some malignant tumors. Although radiation therapy and chemotherapy are elective, symptomatic relief takes 7-10 days to be achieved, and poor symptomatic benefit can be obtained in relapsed or resistant tumors. We report on a palliative approach using Wallstent catheters placed percutaneously in a series of 16 patients. Results obtained in relief of symptoms were excellent (complete response of cephalea, jugular enlargement, and collateral circulation achieved in 100% [16/16] of patients; complete response of edema obtained in 93% [15/16] of patients). Achievement of symptomatic response was obtained for all symptoms during the first 24 h poststenting, except for edema and dyspnea. Mean duration of patency of the stents was 6.4 months (range 2-17 months). Rates of morbidity and complications were very low. Dyspnea was a quite resistant symptom, and only four of 13 patients (31%) obtained complete response, while partial improvement was obtained in the other nine (79%). However, placement of the stents does not preclude the use of radiation therapy or chemotherapy. We think that these results and those from other studies warrant larger multicentric trials.

Aged↗
PubMed1996

[Nephrolithiasis in children].

We reevaluated the medical records of 112 children with urolithiasis. The prevalence of this condition was 1/4.500 children admitted to our hospital. The mean age was 8.2 years and 54.4% of the afflicted patients were males. Fifty percent of the patients studied had a family history of urolithiasis. The two most frequent etiologies were urinary tract infections and metabolic disorders (hypercalciuria states, distal renal tubular acidosis and cystinuria). The etiology of the urolithiasis was unknown in 15% of our patients. The levels of magnesium and citrate, inhibitors of crystallization, were moderately low in some of the cases in which it was determined. Fifty percent of the children with urolithiasis showed urinary or renal complications. The extracorporeal lithotripsy was an effective treatment of urolithiasis in the patients in which it was performed. The recurrence rate was 8%. In one third of the urolithiasis associated with urinary infections and/or urinary tract malformations we found chronic pyelonephritis.

Child↗
PubMed1993

[The percutaneous management of stenosis in uretero-intestinal diversions].

Five patients with a stenotic uretero-intestinal diversion were submitted to percutaneous balloon dilatation. The stricture was successfully dilated without complications in all cases. One case, however, required another dilatation procedure due to restenosis 30 days later. The low cost, short hospital stay, absence of important complications and low recurrence rate make percutaneous balloon dilatation the procedure of choice in these patients.

Aged↗
PubMed1985

[Schoenlein-Henoch nephropathy in childhood. Clinical and histologic study of 31 cases].

A series of 31 cases of children affected by nephropathy, out of a total of 120 presenting with Schönlein-Henoch syndrome, observed in a period of seven years is reviewed. 87% of the patients evidenced renal involvement in the first month of disease. The manifestations of nephropathy were: Isolated hematuria. Hematuria-proteinuria less than 40 mg/m2/h. Nephrotic syndrome. Hematuria-nephrotic syndrome. Hematuria-nephrotic syndrome renal insufficiency. Biopsy was performed in 13 cases (41.9%). With regard to the ISKDC rules, the histological classification was: type I, one patient; type II, three patients; type III, seven patients; type V, one patient; type VI, one patient. Evolution was favorable in 30 cases, independently of treatment applied, and a complete remission was obtained in all of them.

Acute Kidney Injury↗
PubMed1984

[Review of pseudohypoaldosteronism. Apropos of a clinical case in a 2-month-old girl].

The case of a two month-old child admitted because of dystrophy is presented. At physical examination she presented a growth retardation (-2DS) as well as cutaneous and mucosal pallor. Metabolic acidosis, hyponatremia, hyperkaliemia and salt loss were demonstrated. Aldosterone, both plasmatic and urinary, was increased. Plasma renin activity, was also increased. In respect to renal function, hypercalciuria was found but not other abnormalities neither in the renal nor suprarrenal function were noticed. The electrolytic levels in sweat, saliva and feces were also normal. The clinical and laboratory findings were not modified with the DOCA test. Spirolactone caused an increase in salt loss. Treatment with indometacine improved both the clinical and analytical findings. On the other hand, treatment with chloride sodium (4 gr p.o. per day) also improved dramatically the disturbances. In the last 12 months she has growth up normally. At the same time, the renal loss of sodium has decreased and aldosterone, both plasmatic and urinary, is not so increased as it was at diagnosis. Finally, electrolytic parameters are fully normal.

Age Factors↗
PubMed1982

[Berger's disease. Study of eleven cases (author's transl)].

Among 39 patients with recurrent hematuria, 11 accomplished criteria of Berger's disease. The frequent association between recurrent hematuria and upper respiratory tract infections as well as constant elevation of serum IgA are emphasized. Their finding as well as the deposition of IgA on the mesangium and C'3 without C1q and C'4 suggest an alternative activation of the complement system which could explain the role of the IgA in the pathogenesis of Berger's disease. The disease can begin as acute glomerulonephritis and occasionally as a nephrotic syndrome, and its' prognosis is generally good in most instances.

Child↗
PubMed1982

[Arterial hypertension in acute post-infection glomerulonephritis based on case reports].

Sixty-six cases of acute post-infectious glomerulonephritis, 31,4% of all glomerulopathies diagnosed in our Service were studied. Patients were classified according to the presence (33,3%), or not (66,7%) of arterial hypertension during the acute phase of disease. As far as clinical and analytical data are concerned, the more symptomatic forms were observed among cases with arterial hypertension. However, after the acute phase of disease clinical evolution was similar in both groups.

Acute Disease↗
PubMedDate not supplied

[Primary tumors of the parotid. An anatomicoclinical review].

It was studied 54 cases of tumors of parotid treated in the Hospital Universitario of Granada from 1978 to 1989. It was also studied the patient age and sex, the year and month of disease arise, the tumors stages at diagnosis, the different treatments followed and the histological classification. Finally the results are discussed.

Adenocarcinoma↗
PubMedDate not supplied

[Nephrotic syndrome and hereditary spherocytosis (author's transl)].

A case of nephrotic syndrome associated with hereditary spherocytosis in a 22 month old girl is reported. In an attempt to explain the relationships between these two entities and alteration of lipidic metabolism, red cells count and serum cholesterol during relapses of nephrotic syndrome were compared. Until now only two cases involving this association have been published.

Female↗
PubMedDate not supplied

[Functional nasal tests for the evaluation of the mucociliary transport].

A study was made of a noninvasive functional test of mucociliary clearance using micronized indigo blue colorant, which is insoluble in airway secretions. Transport time to the nasopharynx was measured optically with an endoscope. This method was more objective and less irritating than others tested by other authors. Measurements were made in each subject using different endoscopes. The results were highly suggestive of a difference in nasal mucociliary clearance time between healthy and unhealthy subjects. This may mean that chronic inflammation, atrophic rhitis, dyskinesia, and other diseases lead to malfunction of the nasal mucociliary system.

Adolescent↗