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Biomedical subjects

L Gastoł-Lewińska

Publications and source records attributed to L Gastoł-Lewińska.

8 recordsLinked to original sources
PubMed1994

The role of alpha-1 adrenergic receptors in the stimulating effect of neuropeptide Y (NPY) on rat behavioural activity.

The role of noradrenergic alpha-1 receptors in increasing the behavioural activity after neuropeptide Y (NPY) injection into the frontal cortex was examined in rats. NPY (1 micrograms/1 microliter) injected into the frontal cortex of rats with chronically implanted cannulae, increased their locomotor and exploratory activity in the open field test. Similar effects were observed after injection of the alpha-1-adrenergic agonist phenylephrine (PH) (3-19 micrograms/1 microliter). Behavioural stimulation after NPY or PH was totally abolished by pretreatment with benextramine (1.73-173 micrograms/1 microliter), a compound blocking NPY and alpha-adrenergic receptors. The NPY-induced activation of behaviour was also abolished by i.p. injection of prazosine (3 mg/kg), a specific alpha-1-adrenergic receptor antagonist. It is concluded that: 1) NPY injected into the rat frontal cortex induces an increase in the locomotor and exploratory activity of the animals; and 2) indirect activation of alpha-1-adrenergic receptor seems to play a crucial role in the observed behavioural effects.

Adrenergic alpha-Antagonists↗
PubMed1992

Structure-activity relationship studies of CNS agents. Part 4: 2-[3-(4-aryl-1-piperazinyl)propyl]-1,2,3,4-tetrahydro-beta-carbolin+ ++ -1-one derivatives as potential central anti-serotonin agents.

Seven derivatives of 1,2,3,4-tetrahydro-beta-carbolin-1-one have been prepared. Three of them showed significant central anti-serotonin activity, comparable with that of trazodone or etoperidone. Some structural features were found to be important for the central antiserotonin activity of the investigated class of compounds.

5-Hydroxytryptophan↗
PubMedDate not supplied

Influence of N-3-pyridoyltryptamine (tryptamide) on fetal development in rats and mice.

N-3-pyridoyltryptamine (Tryptamide, TRP) was examined for embryotoxic and teratogenic activities in rats and mice. Female Wistar rats and Albino Swiss mice were given TRP per os on days 6-14 of gestation. The rats were killed on day 21, and mice on day 18 of pregnancy. The general health and reproduction of females were evaluated, and fetuses were examined and processed to characterize external, visceral and skeletal malformations. TRP given to mothers in doses of 10 to 500 mg/kg po did not produce statistically significant embryotoxic or teratogenic effects in rats. It was not teratogenic also in mice but in this species the dose of 500 mg/kg produced embryotoxic effects.

Animals↗
PubMedDate not supplied

Karyometric studies in brains of fetuses from mothers kept under conditions of low methionine supply.

Volumes of nuclei of nervous cells of cortex (C) and caudate nucleus (CN) in brains of fetuses of mothers maintained on methionine--low diet (MLD) or on standard diet (STD) for 2 months before conception and throughout pregnancy were compared acc. to Hintzsche. In both brain areas the class ranges of C and CN nuclei of nervous cells were shifted to the left in fetuses from mothers maintained on MLD and this distribution difference was highly statistically significant. This shows that the nuclei of nervous cells of fetuses of mothers maintained on MLD were retarded in growth.

Animals↗
PubMedDate not supplied

Lack of teratogenic and embryotoxic properties of (2S, 2'S) N,N'-dimethyl-N,N'-bis [1-(3', 4', 5'-trimethoxybenzoyloxy)-butyl-2] ethylenediamine dihydrochloride (M-71).

(2S,2'S) N,N'-dimethyl-N, N'-bis[1-(3', 4', 5'-trimethylbenzoyloxy-butyl-2] ethylenediamine dihydrochloride (M-781, Craviten Polfa) was examined for teratogenic and embryotoxic activities in rats, golden hamsters and rabbits. Doses ranging from 3 to 450 mg/kg po i.e. 1/1500 to 1/10 of LD50 for mouse in all examined species showed no action suggesting teratogenic and embryotoxic properties. In contrary the development of fetuses of rats and hamsters (as indicated by body weight and length) was significantly better after all doses tested.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Karyometric studies on brains of the golden hamster fetuses from mothers kept under low methionine supply.

We investigated the size of cell nuclei in brains of the golden hamster fetuses from mothers kept on protein-methionine-low diet (PMLD) from two months before conception through pregnancy. The frequency of volume class ranges of nervous cell nuclei in the cortex and caudate nucleus of 16 days old fetuses from PMLD mothers significantly differed from that in fetuses from mothers fed with standard diet. The differences in distribution of the frequency of occurrence of cell nuclei volumes indicated an inhibition of the mitotic activity in the PMLD fetuses.

Animals↗
PubMedDate not supplied

Phenylalanine deficiency in the food of rat. Part II. Decrease in fertility by phenylalanine deficiency in pregnancy.

Female rats fed on a phenylalanine-low diet (PheLD) before mating and 21 days afterwards did not become pregnant. Feeding with PheLD after mating, for shorter periods, diminished fertility and caused malformations in fetuses. Continuation of PheLD in feeding mothers for 3 weeks post partum caused the death of all newborns, while if mothers fed with PheLD during pregnancy were switched to standard diet post partum, their offspring did not show signs of phenylalanine deprivation.

Animals↗