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Biomedical subjects

L Giacchetti

Publications and source records attributed to L Giacchetti.

7 recordsLinked to original sources
PubMed1993

Usefulness of neonatal eosinophil counts as a marker of atopy?

Eosinophil count (EC) were obtained from 312 newborns with and 172 without family history of atopy (FHA). The EC were higher in infants with than without FHA. Elevated EC were recorded in babies of parietaria sensitive mothers born in the spring, as compared to other seasons. The predictive value of EC with regard to development of atopic diseases up to 18 months of age was prospectively studied in 103 newborns with FHA. Using 5 x 10(8) cells/l as cut-off level the predictive allergy value was 41%. Elevated EC appears to be a marker of atopy in newborns.

Biomarkers↗
PubMedDate not supplied

[Basophil count of the newborn is not useful in prediction of allergic diseases].

Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 108 children were prospectively studied with a follow-up to 18 months of age for development of topic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil count higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (r = 0.013), between basophil count and serum total IgE levels (r = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was respectively only 33% and 27%. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.

Age Factors↗
PubMedDate not supplied

Basophil count in neonates is not suitable for atopy predictivity.

Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 102 children were prospectively studied with a follow up to 18 months of age for development of atopic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil counts higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (rs = 0.013), between basophil count and serum total IgE levels (rs = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was only 33% and 27%, respectively. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.

Basophils↗
PubMedDate not supplied

[Respiratory function tests in the newborn and the infant].

We evaluated respiratory mechanics in healthy or with respiratory diseases newborns and infants. We used a facial mask collected with a pneumotachograph and a software. We obtained flow-volume and flow-time loops which are useful for evaluating lung function in non collaborating infants. We studied babies with pulmonary broncho-dysplasia, vascular ring, bronchial asthma and others neonatal respiratory problems. Tptef/Texp evaluated in healthy newborns during flow-time seems to be predictive for respiratory problems.

Humans↗
PubMedDate not supplied

Low breast milk IgA and high blood eosinophil count in breast-fed newborns determine higher risk for developing atopic eczema after an 18-month follow-up.

Eosinophil count and IgA breast milk were evaluated at birth in 120 mother-newborn pairs with an 18-month prospective follow-up study. Our study showed a higher risk of developing atopic eczema in newborns with eosinophil count higher than 500 cell/mm3 and with IgA breast milk less than 220 mg/dl (odds ratio 17.6 CI 5.4 to 57.2 p < 0.000086). IgA breast milk is significantly less and eosinophil count is significantly higher at birth in children who develop atopic eczema. This study demonstrates the usefulness of newborn eosinophil count and mother total IgA breast milk level as combined risk factors in the development of atopic eczema in breast-fed babies.

Adult↗