PubMed Health⌕ Search

Biomedical subjects

L Giarelli

Publications and source records attributed to L Giarelli.

At least 37 records · Page 2Linked to original sources
PubMed1986

Optic nerve in diabetes mellitus: a case control study.

The pathology of optic nerve in 80 diabetic subjects has been investigated in a morphologic study performed on autoptic material. Gliosis and demyelination resulted as the most frequently observed lesions (respectively 19 and 18 cases) and were associated to long history of diabetes. Additional findings were focal infarctions, atrophy, and broad spectrum of vascular lesions, mostly affecting the microcirculation, including thickening, hyalinosis, microaneurysms, as well as thromboses. An age-sex-matched control group, made of non diabetic subjects, did not share significantly lesions with the diabetics. Therefore, the authors suggest that diabetes mellitus plays an important role in the development of pathological changes in the optic nerves, thus claiming the marked vascular damage of early age onset diabetes as a possible pathogenetic factor.

Aged↗
PubMed1984

Incidence of hepatocellular carcinoma in the Trieste area over a 15-year period (1968-1982).

An analysis of 26,700 unselected autopsies performed consecutively over a 15-year period was made to establish the incidence of hepatocellular carcinoma (HCC) and its relationship to cirrhosis of the liver in the Trieste area. In our series, considering the period 1968-1980, the average value of the annual age and sex incidence rates of HCC standardized to the European population proved to be 10.58/100,000 in cirrhotic males and 1.3/100,000 in cirrhotic females, whereas in non-cirrhotics it was 1.14/100,000 and 0.34/100,000, respectively. In cirrhotic males autopsied during the period 1977-1980 the above incidence increases, its average value being 16.53/100,000.

Adult↗
PubMed1979

Giant-cell pneumonia and lung tumorlets in a leukemic four-year-old child.

The authors report a case of a 4-year-old child whose death resulted from acute lymphoblastic leukemia (ALL) and giant-cell pneumonia. Typical lung tumorlets were occasionally observed. On electron microscopy study it was possible to demonstrate a large number of neurosecretory granules in the tumorlet's cells, identical to those present in Kulchitsky's cells. These studies suggest the occurrence of an abnormal immunitary process.

Child, Preschool↗
PubMed1978

[Pathological observations on patients carrying pacemakers and clinical consequences. Reports of 105 observed cases (author's transl)].

In subjects carrying pacemakers, the catheter-electrode can induce, over a period of time, specific modifications at the level of the veins and the heart. The organism reacts to extraneous bodies with adhesive and sometimes thrombotic phenomena. The latter can occasionally be the cause of a pulmonary embolism (8 cases out of 105) or more rarely, the seat of a mycotic infection (one case). In the casuistry are included two cases of the complete perforation of the right ventricle (one of which was fatal) and four cases of partial perforation; in another subject a papillary muscle was perforated. Finally, one case of endocarditis was noted, the so called traumatic type, of the tricuspid valve.

Cardiovascular System↗
PubMed1977

14 cases of cavernous degeneration of the optic nerve.

After a brief bibliographical introduction the author's report on 14 cases of cavernous degeneration of the optic nerve, based upon the study of 1,831 autoptic cases. All the subjects examined showed lesions of a senile degenerative type in the vessels afferent to the retro-laminar segment of the optic nerve. The pathogenetic mechanism of the lesion under examination seems therefore to be attributable to ischaemic cause of a chronic type. Myopia and glaucoma, if present, would also seem to contribute, as they cause disorders of the blood system in this region.

Aged↗
PubMed1975

[Pathogenesis of cerebral hemorrhage considered in the light of objective lesions in the arteries of the brain (in 226 cases studied by autopsy)].

Conclusions drawn from the post-mortem examination of 226 subjects who died of cerebral haemorrhage are presented. There were slightly more women than men (53%) in the series. Arterial hypertension (68%) was the main cause of death, while renal disease, leukaemia, angioma of the pons, and embolism due to bacterial endocarditis were also observed. The most frequently noted sites are listed. Since cerebral haemorrhage follows the rupture of one or more already damaged deep arteries, as assessment was made of the part played by vascular lesions. 13 cases due to leukaemia and 35 to rupture of aneurysms of the polygon of Willis were discarded. In only 20 cases out of 138 in which convincing microscopic evidence of the vascular situation could be obtained was there an absence of significant alterations. The remaining cases consisted of serious hyalinosis (56%), fibrinoid necrosis (13%), and siderocalciosis (12%). An account is also given of the special pathogenetic conditions applicable to cerebral haemorrhage associated wtih serious gastrointestinal haemorrhage or recent myocardial infarct.

Brain Neoplasms↗