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L Giarelli

Publications and source records attributed to L Giarelli.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Primary liver cancer in non-cirrhotic liver. Epidemiological study based on autopsies performed in Trieste, Italy and Kurume, Japan.

This study, aimed at elucidating the epidemiological features of primary liver carcinoma developing in non-cirrhotic livers, was based on 25,103 autopsies performed between 1975 and 1984 in Trieste, Italy. These autopsies correspond to approximately 70% of all deaths that occurred in this area. Various factors allegedly related to carcinomas were analysed in reference to our previous study on cirrhotic livers and in comparison with 5,603 autopsies in Kurume, Japan. There were 28 cases of hepatocellular carcinoma (HCC), 16 of cholangiocellular carcinoma (CCC) not associated with cirrhosis in Trieste, and 48 HCC and 19 CCC in Kurume. On the basis of our findings, it was concluded that cirrhosis, regardless of its cause, is the main pathogenetic factor in HCC; it is responsible for a much higher frequency (14.2:1) than in non-cirrhotic livers, as well as for early occurrence of tumours (an average of 6 years earlier in cirrhotic liver) in Trieste. Patients in Trieste were older than those in Japan, and the frequency of HCC among all autopsies was much greater in the latter. By contrast, the influence of cirrhosis on cholangiocellular carcinoma (CCC) was negligible, as such association appeared purely coincidental or absent. The incidence of CCC among autopsies was greater in Japan. Our data on CCC were not sufficient to demonstrate any clear aetiopathogenetic association between this tumour and alcohol abuse and hepatitis B virus (HBV) infection, except for a possible aetiological role of gallstones. The frequency of CCC relative to HCC was greater in Trieste than in Japan; the incidence of HCC was much less in Trieste, whereas CCC was more frequent in Japan.

Adenoma, Bile Duct↗
PubMedDate not supplied

[Ovarian metastases of extragenital tumors. Anatomo-pathological contribution to their interpretation].

Ovarian metastases from extragenital malignant tumours. An anatomohistopathologic approach. 102 cases of ovarian metastases from extragenital malignant non hematopoietic primaries have been studied in the Institute of Anatomy and Histopathology of the Trieste University. Breast cancers, followed by colonic, gastric and pancreatic tumours are the most frequent spreading primaries to the ovaries. Generally speaking the ovarian metastases seems to be closely related to the lower age at the tumour onset and to the width of metastatic spreading; this is true mainly for breast and colorectal cancer. These features should suggest that tumour aggressiveness, rather than some tropism of malignant cells, could play the most important role in the metastatic involvement of ovaries. A double behaviour should be instead suggested for gastric cancer: the first one is consistent with those previously described for the other tumours, the second one is related to a less aggressive gastric cancer, arising in the elderly (mean age 73 years old) with isolated involvement of the ovary showing the features of Krukenberg tumours.

Adult↗
PubMedDate not supplied

[Pure squamous cell carcinoma and mixed transitional and squamous carcinoma of the bladder. A clinico-histopathological comparative study].

The histopathological features and clinical courses of 32 patients with pure squamous cell carcinomas of urinary bladder and 42 mixed squamous and transitional carcinomas were compared. The natural history of 2 patients populations was based on the staging of specimens on which first histological diagnosis was made and on the specific treatments adopted. No significant differences in behaviour between two histological types were observed, even though median survival of pure squamous forms was lower than that of mixed forms. Only radical treatments seemed to offer a better prognosis for mixed transitional and squamous forms with pT2 stage, whereas none of the patients with squamous carcinomas survived for two years regardless of stage and treatment performed. A common origin between the two histological types of tumour is supposed.

Aged↗
PubMedDate not supplied

[Primary adenocarcinoma of the bladder].

A clinicohistopathological study of 12 cases of primary adenocarcinoma of the bladder diagnosed over an 11 year period is presented. Six of these were pure adenocarcinomas, while the remainder consisted of 2 adenocarcinoma with transitional malignant elements, 2 adenosquamous carcinomas and 2 mesonephric adenocarcinomas. The biological behaviour of these neoplasms was particularly aggressive: in none of the cases was the neoplasm limited to the bladder epithelium, but was generally seen to have infiltrated the muscular wall. Leaving aside the specific treatment carried out, the prognosis was in all patients poor and a complete clinical recovery was achieved for just 2 subjects. Except for one case, death was always directly attributable to bladder cancer, but as a result of obstructive and inflammatory diseases relating to the size and the degree of local infiltration of the tumor rather than metastatic spread.

Adenocarcinoma↗