[Controlled clinical testing of a corticosteroid-salicylic-acid tincture (EMD 29 358)].
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Biomedical subjects
Publications and source records attributed to L Gip.
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Fine, brownish lines, similar to chloroquine keratopathy, were observed in two of 19 psoriatic patients given clofazimine. There was no functional disturbance and the changes were reversible.
The percutaneous absorption of betamethasone-17, 21-dipropionate and salicylic acid was studied after one and two weeks' treatment of psoriaris and eczema. The treated areas varied between 8 and 41 dm2. No change in the plasma cortisol levels was detectable by the routinely used laboratory method. The treatment gave no detectable salicylate concentrations in plasma.
Eight patients had pyoderma gangrenosum. They were given a phendimetrazine tartrate derivative, clofazimine (Lamprene [Britain]), which is a chemotherapeutic agent used mainly in certain mycobacterial infections and which also has phagocytosis-enhancing properties. The effect of this drug was remarkably good, with rapid healing of the lesions commencing 3 to 14 days after treatment was started. The mechanism for the effect of clofazimine in pyoderma gangrenosum is not known.
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