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L Groch

Publications and source records attributed to L Groch.

27 records · Page 2Linked to original sources
PubMed1993

[Are central hemodynamics the decisive factor in the manifestation of chronic heart failure?].

In the past some authors revealed that data assembled during examinations of the central haemodynamics, echocardiography, subjective complaints, physical findings and load tolerance in patients with chronic heart failure are not mutually consistent. The authors examined therefore comprehensively 40 patients with different grades of cardiac failure. They revealed very loose relations between the grade of functional classification, echocardiographic and invasive haemodynamic parameters at rest on the one hand and spiroergometric indicators on the other hand. Closer relations with spiroergometric findings were obtained with values of invasive haemodynamic parameters after a load, in particular values of the cardiac index, and systemic vascular resistance. The authors conclude that for clinical manifestations of chronic cardiac failure the peripheral circulation and tissue metabolism is at least equally important as changes of central haemodynamics. Moreover, the importance of the right ventricular function and diastolic cardiac function is not sufficiently appreciated.

Adult↗
PubMed1993

[The effect of creatine phosphate (Neoton) in acute myocardial infarct (a prospective multicenter pilot study].

The authors investigated in a group of 106 patients with a first myocardial infarction treated by thrombolysis the effect of i.v. administration of creatine phosphate (a new drug with cardioprotective action--Neoton Alfa Schiapparelli Wassermann Co). In the course of treatment electrocardiographic changes were recorded and the presence of arrhythmias examined by the Holter technique. The Neoton group displayed a statistically insignificant but nevertheless obvious trend of electrocardiographically less serious forms of infarction and a lower incidence of infarctions, as compared with the control group.

Female↗
PubMed1992

Cardiac arrhythmias in chronic heart failure.

It has been proven that treatment of chronic heart failure (CHF) with some modern drugs is able to reduce mortality in groups of patients with the severest grades of this disease. The risk of sudden death has been unchanged, however. Out of 49 patients on long-term follow-up, 28 patients are surviving (group A) and 21 died (group B). 52.3% of the dead patients died suddenly. Eight patients in NYHA classes I-II died, all of them suddenly. Contrary to this, sudden death was the cause of death only in three of 13 patients in NYHA classes III-IV (p < 0.001). More severe heart failure was present in group B (NYHA class 2.95 +/- 0.96 vs. 2.18 +/- 0.48 in group A--p < 0.1). Antiarrhythmic drugs were given more frequently in group B (in 47.6% of pts vs. 17.9% in group A--p < 0.05). It is concluded that the occurrence of sudden death is higher in patients with less severe forms of CHF and has not been reduced by the means employed. Use of antiarrhythmic drugs may be dangerous and their indication should be based on results of a comprehensive examination. Use of the implantable cardioverter-defibrillator seems to be the most promising approach in indicated cases.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1991

[The effect of nifedipine and diltiazem on left ventricular function in patients with stable angina pectoris and severe left ventricular dysfunction].

In a double blind crossover five-week trial with a randomized onset in 12 patients with normal blood pressure, stable angina pectoris and more severe left ventricular dysfunction (ejection fraction less than or equal to 40%) the effect of placebo nifedipine and diltiazem on left ventricular function and tolerance of exercise was compared. The investigation was done by means of echocardiography after a load with stimulation of the heart by an oesophageal electrode. As compared with placebo, only diltiazem retarded significantly the period before development of stenocardia on stimulation of the heart. There was no significant difference between nifedipine and diltiazem as regards the effect exerted on the ejection fraction and time which elapsed after stimulation before stenocardia developed. The authors observed an unequal response of patients to the administration of nifedipine and diltiazem (some patients had less favourable findings, although they were not subjectively aware of this deterioration). Therefore these drugs must be administered to patients with angina pectoris and more severe left ventricular dysfunction with care and only if other drugs (nitrates or angiotensin convertase inhibitors) do not eliminate ischaemia and pain.

Adult↗
PubMed1991

[Microscopic changes in intercaruncular endometrium and ovarian follicles in cows 35 days after parturition].

Surface epithelium of intercaruncular endometrium in pluriparous cows, crossbreds of Bohemian Pied cattle with Holstein-Friesian cattle, was not coherent until day 15 after parturition, with a variable height of cells (16-64 microns). Oedematous nature of lamina propria was subsiding gradually. From day 15 to day 20 after parturition the cell height of coherent surface epithelium and uterine glands became equable and stabilized (16-32 microns), and the lamina propria assumed its cellular nature with marked infiltration of polymorphonuclears and lymphocytes. Noticeable symptoms of atresia were demonstrated to occur more frequently in ovaries in the follicular population until day 15 after parturition. From day 10 to day 25 after parturition an increasing occurrence of luteinized follicles with diameters of maximally 3 mm was demonstrated.

Animals↗
PubMed1982

[The effect of long term administration of aflatoxins on the health status of male rats and pigs with respect to morphological changes in the testes].

Long-continued administration of differentiated doses of aflatoxins was studied as to its effect on the over-all health conditions of male rats and pigs. Crude extract of the toxicogenic strain of Aspergillus flavus and was used for the experiments. The amount of aflatoxins is related to the actual content of aflatoxin B1, determined fluorometrically. Feed containing 1.0 mg aflatoxin per kg was administered in feeding trials with rats. Differentiated concentrations (20.0, 4.0, 2.0 and 0.2 mg aflatoxin B1 per day for 211 days) in feed were used in adult boars. After a longer time of administration, rats showed worse health condition and morphological changes corresponding to chronic aflatoxicosis. Serious changes were found during the histological examination of testes, including regressive changes of different intensity in the germinal epithelium of tubules, in some cases resulting in severe dystrophic alterations leading up to complete devastation of the spermiogenic epithelium. Interstitial tissue was considerably oedematous. Clinical manifestation of aflatoxicosis was observed in the boars given 20.0 mg aflatoxin B1 daily. When lower doses of aflatoxin were administered, no clinical manifestation of intoxication was recorded. In all cases, though no clinical disease occurred, feed conversion was impaired and weight gains decreased, depending directly on aflatoxin doses. The health condition was evaluated objectively by haematological examination and by the determination of clinico-biochemical values in blood plasma. The pathoanatomic changes indicated chronical aflatoxicosis. Histological changes in the testes of boars given 4.0 and 20.0 mg aflatoxin B1 daily in feed occurred within 63 to 190 days. The testes showed different degrees of dystrophy leading to the destruction and atrophy of spermiogenic epithelium and to oedema in the tissue. The extent of the histological changes testifies to a significant damage caused to the spermiogenic epithelium of seminiferous tubules after long-continued administration of high doses of aflatoxins.

Aflatoxins↗
PubMed1982

[Cytodiagnosis of pleural exudates with electron microscopy. I. Activated pleural mesothelium].

Detailed examination of 48 pleural exudations showed that a sequence of morphological changes [desquamation, proliferation, activation, degeneration] was a uniform response of mesothelium to various pathological stimuli. Desquamated mesothelial cells grow round and bigger, their nuclei increase, multiply, become irregular and get a coarse chromatin pattern. Their cytoplasm is less often homogeneous, a bit basophil and mostly vacuolized to some extent; fusion of vacuoles can lead to a signet-ring appearance. Provided that highly activated mesothelial cells phagocytize foreign corpuscular material, they cannot be distinguished from the macrophages. Their cytoplasmic organelles multiply progressively. More frequent lysosomes occur sometimes with dense lamellated myelin-like bodies. Glycogen particles increase in number substantially in peripheric cytoplasmic zone. Tonofilaments are very conspicuous, arranged round the nucleus, but disappear during progressive mesothelial activation and degradation. Numerous microvilli are gradually reduced in number, change into voluminous plasmatic blebs, and finally, mesothelial surface grow irregular or smooth. In dubious cases, electron microscopy [transmissive and scanning] gives more precise features of organelles and surface structures in activated mesothelial cells and helps to differentiate them from other exudation cells especially the neoplastic ones.

Adolescent↗
PubMed1982

[Cytodiagnosis of pleural exudates with electron microscopy. II. Tumorous exudates of glandular origin].

Detailed examination of 26 pleural exudations by transmissive and scanning electron microscopy gave new cytodiagnostical possibilities. In addition to confirming the light-microscopical criteria of malignancy transmissive electron microscopy characterized the cells of adenocarcinoma by microvilli with common structure, various length, irregular orientation and crossing over or branching. They tend to be a bit widened at their base or top and to cover all the surface of cells. Microvilli in the neighbouring parts of cells are less numerous, irregularly oriented, shortened and interdigitating. Not even here is the surface of carcinoma cells quite smoth in contrast to neighbouring mesotelial cells. Scanning electron-microscopical examination being neither technologically sophisticated nor time consuming enables a scope on cellular surfaces uniformly covered by countless microvilli densely distributed.

Adenocarcinoma↗