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Biomedical subjects

L Grubin

Publications and source records attributed to L Grubin.

8 recordsLinked to original sources
PubMed1987

Enzyme immunoassay for detection of Neisseria gonorrhoeae from urogenital samples.

A solid-phase enzyme immunoassay (Gonozyme) was used to detect Neisseria gonorrhoeae; the results were compared with the results of cultures taken simultaneously from 201 patients from sexually transmitted disease clinics or family planning clinics. Cultures were positive in 32 of 201 consecutive patients seen in the clinics, while the Gonozyme was positive in 28 of these patients. Overall, five positive cultures were not detected by the Gonozyme, and one positive Gonozyme was not confirmed by culture in the 201 patients tested. The overall sensitivity of the enzyme immunoassay was 84.4% and the specificity 99.4%. The predictive values of a positive and negative Gonozyme result were 96.4 and 97.1%, respectively.

Female↗
PubMed1987

Infection with multiple sexually transmitted agents.

A patient named as a contact by an individual with gonorrhea and syphilis was found to be an asymptomatic carrier of seven organisms known to be transmitted sexually. Cultures were positive for Neisseria gonorrhoeae, Chlamydia trachomatis, Gardnerella vaginalis, Mycoplasma hominis, Ureaplasma urealyticum, and Herpes simplex virus. Trichomonas vaginalis was detected by a wet preparation and the Papanicolaou smear. The cervix was found to have an ulcer on the posterior lip that yielded Herpes simplex on culture. Although the venereal disease reaction level (VDRL) and the fluorescent treponemal antibody-absorption tests (FTA-ABS) were negative, and treponemes were not identified on dark-field microscopy, a Jarisch-Herxheimer reaction on this patient raised the possibility that she also had incubating syphilis.

Adult↗
PubMed1985

Evaluation of a serum gonococcal antibody test.

The authors evaluated the Gonosticon Dri-Dot system as a tool for the determination of the prevalence of gonococcal serum antibody in two female populations. This paper discusses their findings.

Adolescent↗
PubMed1982

Vaginitis in sexually active women: relationship to nine sexually transmitted organisms.

Women seen for symptoms suggestive of vulvovaginitis were studied for the detection of Mycoplasma hominis. Ureaplasma urealyticum, yeast, Neisseria gonorrhoeae, Chlamydia trachomatis, Gardnerella vaginalis, herpes simplex virus, group B beta-hemolytic streptococci, aerobes, anaerobes, and Trichomonas vaginalis. Asymptomatic women who reported to be sexually active and agreed to undergo comprehensive genital cultures were used as controls. There was a significant association of vulvovaginitis with the recovery of sexually transmitted organisms. However, all organisms were also recovered from asymptomatic patients. A total of 468 sexually transmitted organisms were recovered from 253 symptomatic patients (1.85 organisms per patient), while 125 were recovered from 130 asymptomatic patients (0.96 organisms per patient). The difference in prevalence between symptomatic and asymptomatic women for Chlamydia trachomatis, group B streptococcus, and the mycoplasmas was not statistically significant. Factors that predispose patients to the manifestations of symptoms are not clearly understood.

Adolescent↗
PubMed1980

Gonorrhea screening. Comparison of three techniques.

A total of 1,336 men were screened for gonococcal urethritis by one or more of three techniques: Gram-stain smears, urethral cultures, and cultures of first-voided urine (FVU). The sensitivity of these techniques in a group of 113 symptomatic patients was 99.1%, 98.2%, and 95.6%, respectively. In a group of 248 asymptomatic men, FVU cultures yielded a positivity rate of 2.4%, comparable to the 2.8% obtained with urethral cultures. In view of the reduction in time, cost, and patient discomfort associated with the use of FVU cultures, it appears to be a valuable diagnostic technique for asymptomatic gonococcal urethritis.

Bacteriological Techniques↗
PubMed1979

Genital bacteriology: a comparative study of premenopausal women with postmenopausal women.

Premenopausal women are reportedly at a higher risk than postmenopausal women of postoperative infection following vaginal hysterectomy. A study was designed to determine whether a relationship exists between bacterial flora and patient age that may explain the difference in the risk of postoperative infection. No statistically significant difference was found in the number or type of bacterial species isolated from the cervix or vagina of premenopausal and postmenopausal women. Postmenopausal women on a regimen of conjugated estrogens had genital flora similar to that of the other women studied.

Adult↗
PubMedDate not supplied

Colonization of the pharynx with Neisseria gonorrhoeae: experience in a clinic for sexually transmitted diseases.

At a clinic for treatment of sexually transmitted diseases, 1,453 patients were examined for pharyngeal colonization with Neisseria gonorrhoeae. A history of oral sex was reported by 895 (61.2%) of the patients. N. gonorrhoeae was isolated from the pharynges of 42 (2.9%) of the 1,453 patients. Twenty-seven of the 42 patients with N. gonorrhoeae-positive cultures gave histories of oral sex, and all 42 patients reported orogenital contact when questioned again at a follow-up visit. Seven patients with positive cultures had pharyngeal symptoms; all seven practiced fellatio. Eleven of the infected men were asymptomatic heterosexuals whose only orogenital contact was cunnilingus.

Adolescent↗