PubMed Health⌕ Search

Biomedical subjects

L Gualandri

Publications and source records attributed to L Gualandri.

11 recordsLinked to original sources
PubMed2003

Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and L-cysteine.

The aim of the present study was to investigate the possible normalizing effect of antioxidants on certain parameters indicative of oxidative stress in Down's syndrome (DS). The study was performed in pediatric patients with DS with proven redox imbalance, who were advised to take a dietary supplementation composed of alpha-lipoic acid and L-cysteine for several treatment cycles (one treatment cycle = 30 days dietary supplementation plus 30 days wash-out). Serum thiol groups, serum total and septic reactive oxygen species (ROS) and total antioxidant status of serum were determined before and after dietary supplementation, using commercially available kits. In all the evaluable patients (n = 20), after 3.8 +/- 1.1 treatment cycles, thiol group serum concentrations and total antioxidant status of serum significantly increased (p < 0.0001 for both parameters) in comparison with basal values, while serum total and septic ROS significantly decreased (p < 0.0001 for both parameters). On the basis of these results it is impossible to demonstrate the clinical effects of the biochemical normalization obtained in patients with DS after supplying alpha-lipoic acid and L-cysteine. These data suggest that delaying the clinical expression of redox imbalance in patients with DS might be feasible by normalizing their redox balance.

Adolescent↗
PubMed1999

Neck location of basal cell carcinomas: a new-significant variant?

Basal cell carcinoma of the neck has been suggested to have a distinct clinical, histological and prognostic significance. The aim of our study is to verify this assumption. Among 1,185 basal cell carcinomas, we have observed 42 tumors localized on the neck. The mean age did not differ from that of patients with basal cell carcinomas on other sites, and there was no difference in incidence between sexes. The frequence of recurrence was 4.76%, similar to the recurrence rate of basal cell carcinomas on other sites. The lesions were typed histologically according to accepted criteria. The patterns observed were: nodular (62.8%), superficial (21.1%), mixed (4.7%), micronodular (5.9%), and infiltrative (5.7%). These frequencies did not differ significantly from those observed in the basal cell carcinomas on other sites. Thus, in comparison with the overall basal cell carcinoma population, the tumors of the neck do not represent a particular clinical and histologic subtype and do not have a particular recurrence potential. We think that basal cell carcinomas localized on the neck do not represent a particular subtype of these tumors; their treatment can be the same as that of basal cell carcinomas on other regions.

Adult↗
PubMed1998

Acquired self-healing Blaschko dermatitis in an adult.

A 24-year-old woman with a 3 year history of Blaschkitis is presented. The dermatosis consisted of erythematous vesicular papules following Blaschko's lines on her left trunk. A moderate itching was described by the patient initially. Resolution occurred spontaneously after 3 months with hypopigmentation. Histological examination demonstrated a perivascular inflammatory infiltrate in the subpapillary dermis with lymphocytic exocytosis.

Adult↗
PubMed1998

Previous diathermic therapy at the site of the development of basal cell carcinomas. A hypothesis of association.

BACKGROUND: Factors associated with the development of basal cell carcinomas (BCCs) are radiation exposure, sunlight, trauma, and burns. OBJECTIVE: We wish to further document the relationship between the development of BCCs and previous diathermic exposure for therapeutical purposes. Moreover, we compared the histological subtypes of BCCs developed in patients with or without previous therapy. METHODS: A retrospective study of 1053 patients with BCCs seen at our dermatologic clinic was performed. RESULTS: Twenty-three patients had histories of diathermic therapy for different osteoarticular problems. The interval of time between the treatments and the appearance of the tumor was 12-31 years. The histologic subtypes involved were the same of other BCCs on the same areas. CONCLUSIONS: Our study supports the association of BCCs and diathermic therapy in the development of the tumor of the previously treated areas. Histological subtypes do not seem to be affected by environmental factors but are a characteristic of the site location of the tumor.

Basal Cell Carcinoma↗
PubMed1997

Regional eruptive neurofibromas.

A 71-year-old woman presented with multiple, flesh-colored, papular lesions on the left dorsal side of the hand which had erupted 5 years earlier. No cafè-au-lait spots, freckles, or Lisch nodules were detected. Family history did not disclose neurofibromas or abnormal pigmentation. Two biopsy specimens of the lesions showed circumscribed, non-encapsulated neurofibromas. Segmental neurofibromatosis is characterized by the unilateral, segmental appearance of neurofibromas and/or cafè-au-lait spots in the absence of genetic transmission. The authors discuss the significance of localized multiple cutaneous neurofibromas in the absence of family history and suggest the possibility of a cutaneous hamartoma.

Aged↗
PubMed1995

Basal cell carcinomas of the auricular region: a study of 23 cases.

Basal cell carcinomas (BCCs) of the auricular region are not frequently reported, especially in the Japanese literature. Predisposing conditions such as sun exposure or frostbite are possibly involved in their development. In this study, we report our cases of auricular BCCs, discussing the obtained results, the possible significance of predisposing conditions, and the correlation with the histologic subtypes involved. Among 1094 patients with BCCs, auricular tumors were observed in 23 patients (2.1%), 4 women and 19 men. All of them were present on the external sun-exposed auricular side. Histologic patterns were nodular and micronodular (13 cases) and infiltrative (10 cases). No differences were observed between sexes. The relative degree of elastosis was higher in men than in women. Frostbite was recorded in 4 cases. The ear is an anatomical region that is heavily exposed to sun-light and equally prone to frostbite. Our data showed that all the lesions were located on the auricular region more or less exposed to sunlight. There was a recorded previous history of predisposing factors in most cases, and the high degree of elastosis suggests the involvement of these predisposing factors. Moreover, the high prevalence of infiltrative subtypes observed in our survey suggests a possible correlation between some histologic subtypes, sun-exposure, and frostbite. The differences between the relatively high number of auricular BCCs reported in the literature in contrast with the Japanese observations suggest the involvement of social or local conditions.

Age Distribution↗
PubMedDate not supplied

Multiple familial smooth muscle hamartomas.

Smooth muscle hamartoma is a cutaneous abnormality characterized by a disorganized proliferation of normal muscle fibers of arrector pili. Usually a single congenital hypertrichotic plaque involves the trunk and the extremities. Multiple lesions have rarely been reported in the literature. We describe three members of the same family with multiple skin-colored patches on the back and legs, histologically confirmed as smooth muscle hamartomas. To our knowledge this is the first report of multiple smooth muscle hamartomas in different members of the same family and quite interestingly involving the same skin site.

Adult↗
PubMedDate not supplied

Eruptive dermatofibromas and immunosuppression.

Multiple and eruptive dermatofibromas are, on the contrary, unusual. Often the patients who show this peculiar cutaneous pattern are referred for immunosuppressive therapy or they have an immunosuppressive disease. We report the case of a woman affected by mycosis fungoides, who developed, in 2 months, 14 dermatofibromas on her legs. The personal history of the patient revealed a previous immunosuppressive treatment with systemic corticosteroids for interstitial pneumonia. Different etiological hypothesis have been proposed to explain the eruptive presence of multiple dermatofibromas and the alteration of the immune response, but the real mechanism is still unclear. Dermatofibromas are benign tumours usually encountered in dermatology.

Diagnosis, Differential↗