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Biomedical subjects

L Guize

Publications and source records attributed to L Guize.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Prevalence and course of Wolf-Parkinson-White syndrome in a population of 138,048 subjects].

The prevalence of the Wolff-Parkinson-White (WPW) syndrome, frequency of arrhythmias and their evolution were studied in a group of volunteers consisting in 79,978 men and 59,070 women, aged from 20 to over 70. The higher prevalence of WPW in men than in women (p less than 0.001) decreased significantly with age, much more in men (p less than 0.001) than in women (p less than 0.05). Ventricular pre-excitation was intermittent in 6.7 p. 100 of men and in 16 p. 100 of women. The probable site of pre-excitation, determined on the orientation of the delta wave was more often left than right (104 vs 66, p less than 0.02). The frequency of paroxysmal tachycardia increased with age: 10 p. 100 of the cases from 20 to 39 years of age, 29 p. 100 from 40 to 59, 36 p. 100 at 60 and over (p = 0.05). It was 1.7 times more frequent in cases of left pre-excitation. A hundred and fifty-one patients were followed-up from 1 to 11 years (4.6): 5 patients died, 3 of non-cardiac and 2 of undetermined causes, with one sudden death in a 29 year old man. Fifty-three patients were reviewed 4.5 years after the initial examination: 9 pre-excitations (7 right, 2 left) had disappeared. In conclusion, the higher prevalence of WPW in men decreases with age. This decrease appears to be essentially due to the disappearance of the ventricular pre-excitation and not to an increased mortality. Arrhythmias are more frequent in older patients with left-sided pre-excitation.

Adult↗
PubMed1978

[Distribution and correlations of serum uric-acid in two French adult populations : 13,885 men and 6,861 women (author's transl)].

Distributions and correlations of serum uric acid (SUA) were studied in 13.885 men and 6.861 women who were between the ages of 20 and 90. In men and women the distribution of SUA is unimodal. The average SUA value is 628 mg/100 ml (SD : 1,19) IN MEN AND 5,05 MG/100 ML (SD : 1,10) in women. 27% of the men and 4% of the women have a SUA level above 7 mg/100 ml. In men and in women correlations of SUA with an obesity index is strong (r = 0,272; r = 0,311). In men partial correlations between SUA and age, blood pressure, cholesterolemia, glycemia and hemoglobinemia diminish when obesity index is fixed. In women these correlations are stronger and do not vary when obesity index is fixed. In men and women the correlation between SUA and creatininemia is strong and do not vary when obesity index is fixed.

Adult↗
PubMed1978

[The double ventricular response phenomenon in 2 cases of Wolff-Parkinson-White syndrome].

The authors report two cases of "true" consecutive double ventricular response caused by a single premature atrial stimulation; both were young men with Wolff-Parkinson-White syndrome. In both cases, the presence of a bundle of Kent was confirmed. The phenomenon of double ventricular response arising successively from the bundle of Kent and node-His pathway is rare, being mentioned in only two cases in the literature. It is only found when there is the combination of a good bundle of Kent, fair forward conduction, and a relative ventricle-His retrograde block. Amongst the other mechanisms for double ventricular repsonse, re-entry from branch to branch presents the most difficult differential diagnosis. From our observations, the forward characteristics of the spread through the bundle of His which always procedes the bundle of His which always precedes the second ventricular complex have been confirmed, especially in view of the freat variation in the position of this potential which can easily be explained by variations in intra-nodal conduction. In one of these cases, the atriogram, taken after the second ventriculogram, was provided by retrograde activity in the bundle of Kent.

Adolescent↗
PubMed1978

[Evaluation of sino-atrial function using the method of extrasystole induced by constant-relative premature impulses. 1. Method and normal results].

Atrial pacemaking under conditions of relative constancy (40 or 50% of the preceding cycle) enables us to calculate the immediate sino-atrial conduction time (retrograde and antegrade) (SACT). 17 patients were chosen for their normal sino-atrial function under spontaneous changes of the sinus cycle (SC). In each case, a significant inverse linear relationship was found between SACT and the corresponding SC. The mean correlation slope was -0.36 in 10 patients with no post-pacing depression (PPD). The slope was greater in 7 patients with a PPD (-0.89); if this depression is taken into account when the SACT is calculated, the slope decreases. In 5 patients, atropine (1 mg I.V. reduced the mean value of SC, and shortened (constant relative value) the SACT. The mechanisms for the spontaneous and induced variations in the sinus output are discussed; it may be that there are substitute pacemakers within the cells of the sino-artrial node, which are affected by variations in sympathetic or parasympathetic activity or by pacing. In clinical practice, automatism and conduction with the sinus node should be interpreted as inter-related functions, both under normal conditions and after vagal block.

Adult↗
PubMed1978

[Evaluation of sino-atrial function using the method of extrasystole induced by constant-relative premature impulses. 2. Application in 50 normal and abnormal studies].

The total immediate sino-atrial conduction time (SACT) as calculated by constant relative pacing, 40 or 50% of the immediate sinus cycle (SC), normally varies inversely with the SC. 50 patients were investigated by this method. In 38 patients without sino-atrial block (SAB) on the surface ECG, it was found that the mean slope of correlation between SACT and SC varied with the shape of the curve of Strauss and with the presence or absence of a post-pacing depression. The smallest slope was found in the group in which the curve of Strauss was horizontal in zone II, and in which there was no depression. In the groups with a rising zone II, comparative use of pacing with a fixed relationship in milliseconds suggested a phenomenon of decreasing retrograde conduction. In cases with sinus arrhythmia and a Strauss curve with scattered coordinates, the relationship between SACT and SC was maintained. 1st degree right-sided SAB should therefore be defined as a function of the immediate SC. In 12 other patients with SAB on the surface ECG, the immediate SACT was greatly lengthened so as to be immeasurable, and bore no relationship to the SC.

Adolescent↗
PubMed1977

[Value of the exercise test after aortocoronary bypass].

The 100 patients who underwent an exercise test and a follow-up coronary arteriogram at a mean interval of 10.1 months after an aorto-coronary bypass had suffered preoperatively from incapacitating angina 50%), a threatened infarction syndrome (35%), or Prinzmetal's angina (15%). The majority had a single bypass graft (72%), but 28% had two or three grafts. The exercise test was positive 39 times, negative 51 times, and indeterminate in 10. Correlation with the clinical picture shows that 27% of the patients in functional category I had a positive exercise test. Correlation with coronary arteriography shows that a positive test is reliable evidence for a defect or occlusion of the graft. On the other hand, a negative exercise test is a less reliable indicator of a good result. No instances of positive exercise tests were found when there was complete alleviation of the coronary condition.

Adult↗
PubMed1976

[Sinus node function in man. Statistical analysis].

The sinus function of 60 patients was studied by atrial stimulation at a fixed rate, and also at a rate linked with the preceding sinus cycle. These patients were divided into 3 groups according to the surface-recorded ECG; 10 had clear evidence of sinus dysfunction, 23 had an isolated sinus bradycardia, and 27 were considered as controls a their sinus rate was above 60/min., with a normal PR interval. Calculation of the limits of tolerance showed that at the 5% level, 95% of the values for all the controls fell between 96.8 and 568.7 ms for the corrected post-stimulatory pause, and between 114.5 and 434.3 ms for the corrected maximum return cycle. A study of the distribution zones of the graph CT/CR-AA/AA proved that an absent zone II is a pathological finding. In the group of sinus bradycardias the limits of what constitutes pathology are less clear, and the situation is not improved by noting whether atrial "echos" are present or absent. Because there is a narrow positive correlation between the values given by the two methods, the physio-pathology of sinus dysfunction can be discussed.

Bradycardia↗
PubMed1975

[Pacemaker treatment of tachyarrhythmias by programmed rate-related interval stimulation(author's transl)].

Programmed rate-related interval stimulation proved to be a low-risk method when applied to 74 patients with drug-resistant ventricular tachycardia or runs of ventricular extrasystoles as precursors of tachycardia. Atrial flutter was converted to atrial filbrillation and sinus rhythm by atrial interval-related multiple stimulations. Tachycardias, which could not be terminated by simple or double stimulation, were successfully suppressed by sequential ventricular R-R related multiple stimulations. Rare-related stimulation has proved to be an alternative method of treating tachy-arrhythmias unresponsive to conventional means.

Aged↗
PubMed1975

Premonitory sign of heart block in acute posterior myocardial infarction.

The appearance of the ARS complex in leads V3R and V4R was analysed in a series of 94 patients with acute posterior myocardial infarction. The cases of posterior myocardial infarction with direct signs of injury (ST segment elevation with a rise of 0.5 mm or more of point F and/or QS pattern) in leads V3R and/or V4R were complicated three times as often by atrioventricular block as those in which such signs were absent (66% and 22%, respectively; P smaller than 0.001). When one of these signs was present in leads V3R and/or V4R, the disorder of conduction was "severe" (complete atrioventricular block or sinotrial block with pauses) in half the cases and "unstable" (bradycardia below 50 beats/min; ventricular pause with or without syncope; widening of QRS complex; ventricular hyperexcitability) in one-third, justifying the introduction of a stimulating catheter. Such disorders were found, respectively, only 1 in 7 (14%), and less than 1 in 10 (8%) when these signs were absent (P smaller than 0.001). The association of ST segment elevation and QS pattern was rarer (15 cases) than the isolated finding of either sign. It was found in the most severe disorders of atrioventricular conduction. The changes observed in leads V3R and/or V4R before the appearance of atrioventricular block enable one to predict which patients with posterior myocardial infarction are the most likely to develop atrioventricular block. These electrocardiographic features seem to indicate septal involvement.

Adult↗
PubMed1975

[Unruptured aneurysms of Valsalva sinus of septal origin].

Aneurysms of Valvsalva sinus unruptured into a cavity, but developing into the membranous and even muscular interventricular septum are exceptional. Two cases illustrating this fact are reported. In one of them, a massive mitral incompetence by elongated chordae tendinae related to the presence of a voluminous intra-septal pouch. Atrio-ventricular and intraventricular conduction disturbances were present in both patients. The interest of supra-valvar angiography which makes it possible to advise operation before the eventual rupture is underlined.

Adult↗