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L Gyarmati

Publications and source records attributed to L Gyarmati.

At least 37 records · Page 2Linked to original sources
PubMed1976

The fate of Depogen in rats.

Studying the metabolism of Depogen in rats we have worked out a method for the purification, isolation and separation of the drug and its potential metabolites. In the basic fraction we have found the same metabolic pathway of Drotaverin published earlier by us. In the focus of our recent work was the fate of the theophylline-7-acetic acid and its eventual biotransformed products. We have stated that theophylline-7-acetic acid contrasts with the theophylline excresa in unchanged form, which has been confirmed by several methods.

Acetates↗
PubMed1975

Data on the metabolism of benzylisoquinoline derivatives. The metabolism of drotaverin.

Studying the metabolism of drotaverin (No-Spa¿), we have elaborated a method for the isolation, purification and separation of metabolites and of drotaverin excreted in unchanged form in the urine and feces. The structure of the chief metabolites was cleared by t.l.c., polarography, UV spectrophotometry, and mass spectrometry. It was stated that beside drotaverin excreted in unchanged form, the biotransformation of the molecule results in the formation of oxidation and desalkylation products.

Animals↗