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Biomedical subjects

L H Wee

Publications and source records attributed to L H Wee.

6 recordsLinked to original sources
PubMed1999

Remifentanil infusion for major abdominal surgery in small infants.

Neonates are known to be sensitive to volatile anaesthetic agents which may lead to prolonged recovery. In this study, a remifentanil infusion was used in conjunction with an infusion of epidural ropivacaine and isoflurane anaesthesia for major abdominal surgery in small infants. This led to a short recovery time for infants aged 7 days to 3 months but a prolonged recovery in those under the age of 7 days. Good perioperative analgesia was achieved.

Abdomen↗
PubMed1996

The incidence of post dural puncture headache in children.

One hundred and five children with malignant disease attended for lumbar puncture which was performed under general anaesthesia. A questionnaire was answered over the next three days to determine the incidence of post dural puncture headache Ninety-seven questionnaires were returned and the results show that no child aged under ten years developed a headache. Of the children aged 10-12 years, two out of seventeen developed a headache (11.8%). In children aged 13-18 years, five out of ten developed a headache (50%).

Adolescent↗
PubMed1988

Ethyl eicosapentaenoate restored the immunosuppression in mice fed fat-free diet.

The effects of eicosapentaenoic acid (EPA) on the humoral immune response in fat free diet-fed (FF) mice were studied. The lowered anti-SRBC PFC activity of ICR male FF mice was restored in a dose-dependent manner when EPA was administered orally at doses of 60-360 mg/kg/day for 20 days. In in vitro experiments, EPA similarly enhanced anti-SRBC PFC activity but did not affect the response against lipopolysaccharide. Furthermore, EPA did not cause any substantial effect on T suppressor cell activity induced by Concanavalin A in vitro. On the other hand, T helper cell activity induced by keyhole limpet hemocyanin was augmented. From these results, it is suggestive that EPA caused immunopotentiation to FF mice at least partially by an enhancement of T helper cell activities.

Animals↗
PubMed1986

The effect of inhaled 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in man.

Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects inhaled increasing concentrations of 5-HT and methacholine, and airway response was measured as FEV1, Vmax30 and sGaw. All subjects bronchoconstricted with methacholine, geometric mean provocation concentrations causing a 20% fall in FEV1 (PCf20) for the normal, atopic non-asthmatic and atopic asthmatic subjects being 28.6, 18.3 and 0.71 mM respectively. In contrast, 5-HT up to a maximum concentration of 77 mM had no consistent effect on FEV1, Vmax30 or sGaw in any of the subject groups. Thus, in contrast to a variety of animals, 5-HT is unlikely to serve as a significant bronchoconstrictor mediator in man.

Administration, Inhalation↗