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Biomedical subjects

L Handl-Zeller

Publications and source records attributed to L Handl-Zeller.

At least 19 recordsLinked to original sources
PubMed2005

Teleradiotherapy of joints in rheumatoid arthritis: lack of efficacy.

BACKGROUND: Low dose radiotherapy is commonly used for painful rheumatic conditions in clinical practice. Teleradiotherapy may be a cheap, painless procedure which is applicable to many joints at a time. OBJECTIVE: To determine if the local application of x rays to inflamed joints in rheumatoid arthritis (RA) affects the signs and symptoms of inflammation. METHODS: In a randomised, controlled, double blind study, roentgen irradiation was administered in a total dose of 20 Gy during 2 weeks to single joints in six patients with RA who were receiving constant and stable pharmacological treatment with DMARDs and NSAIDs. Single inflamed joints on the contralateral side of the body were used as controls and received sham irradiation. Swelling and tenderness was assessed by blinded investigators before and until 3 months after the irradiation; general disease activity and pain scales were included in the assessment. RESULTS: No change in the scores for tenderness, swelling, pain, or disease activity was seen. The trial was stopped for ethical reasons. CONCLUSION: Local roentgen treatment of RA at a substantial dose of 20 Gy was ineffective in this pilot trial.

Adult↗
PubMed1994

Experimental perforating injury with high energy electrons to inhibit intraocular proliferation.

Since 1980, the fibroblast model creating experimental proliferative vitreoretinopathy has been used to evaluate the antiproliferative effect of various drugs. In previous studies radiation therapy was found to reduce effectively intraocular proliferation in this model. We therefore investigated the effect of high energy electrons in a standard perforating injury model creating a traumatic proliferative vitreoretinopathy. In 36 eyes we performed a 8 mm pars plana incision and injected 0.4 ml of 80% fibronectin solution intravitreally. Ten rabbits (20 eyes) received radiation therapy with a Betatron accelerator in a total dosage of 3000 cGy to each eye divided into 10 single fractions starting on the first post-operative day. Maximum concentration of the dose was focused to the posterior vitreous. The other 9 rabbits, 18 eyes, served as control. In our perforating injury model we observed a reduction of retinal detachment rate of 72% in the controls to 55% in the treated group. The effect of radiation therapy with high energy electrons and total dosage of 3000 cGy was not statistically significant in experimental traumatic proliferative vitreoretinopathy.

Animals↗
PubMed1993

Analysis of temperature distributions of interstitial hyperthermia using a hot water system.

PURPOSE: Interstitial hyperthermia is being increasingly used as an adjunct to brachytherapy in the treatment of implantable tumors. Of the several interstitial hyperthermia systems available, perhaps the simplest to use are the circulating hot water systems. An analysis of the thermal distributions obtained during our initial experience with interstitial hyperthermia using steel needles and the KHS-9 hot water system was therefore undertaken. METHODS AND MATERIALS: Between September 1988 and June 1991, 23 patients were treated with interstitial Iridium-192 high dose-rate brachytherapy immediately followed by interstitial hot water hyperthermia. A total of 32 implants were performed in these patients, of whom 14 presented with primary anal carcinomas, six with recurrent gynecological tumors, and three with subcutaneous metastases from malignant melanoma. All but the patients with anal cancers had failed in previously irradiated sites. One or two heat treatments were delivered to each tumor with the goal to reach and maintain an intratumoral temperature 42.5 degrees C over a period of 40 min. Temperature measurements were carried out by mapping three-point thermocouple probes along the track of one or two needles parallel to the implanted needles. RESULTS: Minimum intratumoral temperatures exceeded 42.0 degrees C in 41%, 42.5 degrees C in 19%, 43.0 degrees C in 13%, and 44.0 degrees C in 3% of treatments. The average minimum, maximum, and mean intratumoral temperatures for all treatments were 41.7 degrees C, 43.5 degrees C, and 42.6 degrees C, respectively. CONCLUSION: The temperature profiles obtained in this series compare favorable to those reported in literature for radiofrequency local current field systems and suggest the hot water device may be an alternative heating method. It is relatively simple to use, does not require shielding of the treatment room, and can easily be adapted to currently used brachytherapy systems. Further patient accrual and longer follow-up will be needed to assess the clinical results in terms of tumor response and duration of response.

Anus Neoplasms↗
PubMed1993

Irradiation pretreatment before fibroblast implantation in experimental PVR.

Fibroblast injection into the vitreous body causes traction detachment in the rabbit's eye. Various working groups reported different results on the main causes of the development of experimental PVR. These contradictions encouraged us to investigate the main source of experimental PVR by irradiating the ocular tissues before fibroblast implantation thus suppressing cell proliferation originating from host tissue. Over a period of 3 weeks, 22 eyes received ten radiations in a total dosage of 3000 rad. After the last radiation, 250,000 fibroblasts were implanted into 22 eyes. In another 4 eyes, fibroblast implantation but no radiation was carried out. After 8 weeks, 59% of 22 eyes developed different stages of retinal detachment. Comparison with the group of unirradiated eyes, which developed retinal detachment in 85%, revealed no significant differences in the number of detachments.

Animals↗
PubMed1993

Influence of size of primary breast tumour on local control.

Four hundred and five (405) patients with histologically proven primary breast carcinoma were analysed in this study. There was complete response of 64.2% after surgery and radiotherapy. This is a better result in comparison with developing countries, for example, Nigeria where over 90% of cancer patients report at a late stage before treatment and inadequate radiotherapy facilities lead to long waiting list. A tumour regression rate (complete and partial) of 98.3% was obtained. This work has shown that most women with breast cancer could be cured when the lesions are detected very early and sizes smaller.

Adult↗
PubMed1993

Endosonographic features of the lower pelvic region in Crohn's disease.

Anorectal complications in long-term Crohn's disease are frequent and evaluation of inflammatory changes in the lower pelvic region is difficult. Abnormalities are fistulas and abscesses which can be demonstrated rapidly and easily by endosonographic measures. Further topographical localization of the abnormalities is possible. Over a period of 2 yr, 55 patients with anorectal complications were examined. Using endosonography, 46 fistulas were found in 36 patients. Forty patients presented inflammatory changes. Abscesses were demonstrated in four cases. Our findings were verified by surgery, fistulography, and correlation with clinical course of illness. Limiting factor of the examination procedure proved to be painful and strictures in male patients, whereas in female patients the alternative of performing the examination via vagina was given. Our results demonstrate that endosonography is an excellent screening method for detecting and evaluating fistulas and abscesses in Crohn patients. Omitting radiation exposure is a further advantage of endosonography.

Abscess↗
PubMed1992

Radiation of jejunal interposition in T3-T4 upper aerodigestive tumours.

30 patients with T3 and T4 tumours of the upper aerodigestive tract had their tumours resected by pharyngolaryngectomy. This was followed by reconstruction of a gullet or creation of a siphon as a tracheohypopharyngeal shunt for voice restoration with a free jejunal autograft. All patients were treated postoperatively with 60Co gamma radiation, 6 MeV photons or 7.5 to 10 MeV electrons of a beta-tron, with a dose of 50-65 Gy in the area of the primary tumour and 50-65 Gy to the neck. 4 patients refused further treatment after a depth dose of between 16 and 32 Gy. Local recurrence occurred in 40% of cases. The survival rate was 36.6% (11/30) after a mean follow-up time of 21.5 months, although 2 patients died of intercurrent diseases without recurrence of their tumours. The results obtained justify active surgical intervention with postoperative irradiation even at an advanced stage of the tumour.

Aged↗
PubMed1992

[Transrectal sonographic (TRUS) prostatic volumetry in assessing tumor response to radiation].

The aim of this study was to document the grading-related response of carcinoma of the prostate to radiotherapy, especially in views of the fact that the PSA values of hormonal therapy are not evaluable if hormonal therapy is done prior to radiotherapy or in patients with high likelihood of metastatic spread. Controls were done on 55 patients before, during and after primary external radiotherapy of carcinoma of the prostate with volumetric analysis of transrectal ultrasound (TRUS) of the prostate. There were significant differences between G1 and G2 tumors on the one hand and G3 tumors on the other hand. The latter had a much larger volume to start with and their volume reduced more rapidly after therapy.

Aged↗
PubMed1992

[The disease coping of radiation cancer patients compared].

Emotional well-being and physical complaints of 87 outpatients undergoing radiotherapy were compared with those of a variety of other patients. The emotional and physical status were assessed by a list of emotional symptoms (German: "Befindlichkeitsskala") [18] and a list of physical complaints (German: "Beschwerdeliste") [19]. Although they have to cope with a fair amount of physical strain, values of the "oncologic group" rank second lowest, outranked only by healthy controls. The results strengthen the hypothesis of an adaptive denial to cope with the strain of the treatment. In conclusion, concrete suggestions are made for the doctor-patient relationship.

Adaptation, Psychological↗
PubMed1992

[The psychosocial care of cancer radiology patients--the requirement, subjective need and acceptance].

The topic of the investigation was the discrepancy between the documented objective need for psychosocial support of cancer patients on the one hand, and of the patient's little subjective needs on the other, the latter resulting in only low acceptance of care offered. In an empiric study the attitude of 38 radio-oncological patients (29 female, nine male) toward psychosocial support was investigated. The study revealed a tendency, independent of sex, that may be described as a social retreat (e.g. emphasis on personal independence, desire not to burden anybody, to hold back own interests and feelings, to be of help rather to others). We interpret this attitude as a specific reaction of coping with the problem, attempting at self-stabilisation.

Adult↗
PubMed1991

[Incidence of osteoradionecrosis after combined radiotherapy-chemotherapy of head and neck tumors].

Combined modality therapy, consisting of radiation, chemotherapy and surgery are used to treat primary tumours aiming to preserve function and increase tumour control. In the present prospective trial 112 patients underwent combined preoperative radio-chemotherapy, 35 patients were treated with combined radio-chemotherapy as only treatment. At a median follow-up of 26 months eight patients (2.8%) have developed an osteo-radionecrosis, which is comparable with data from the literature. When known risk factors are avoided the incidence of osteo-radionecrosis is not increased following combined therapy. The most important factors for development of osteo-radionecrosis following radio-chemotherapy are large tumours and tumour infiltration in the mandible.

Combined Modality Therapy↗
PubMed1991

Dose estimation in postoperative keloid irradiation with special consideration of ovarian dose.

For a long time now, surgery followed by irradiation has been the preferred therapy in the treatment of keloids. Radiation can be administered by means of X-rays (energy level less than or equal to 100 KV), electrons (energy level less than or equal to 5 MeV) or 192Ir wires. The choice of one of these methods depends on the availability of suitable facilities within a short period of time (less than 24 hours postoperatively), and the possibility of adapting the irradiation field quickly and easily to the scar. A further criterion is the dose received by underlying organs possibly, especially the ovaries of women of child-bearing age. It consists of primary and secondary (scattered) parts of radiation and was measured in two standard field sizes for the various types of radiation so as to allow a rapid evaluation. Apart from the types of radiation mentioned above, such measurements were also carried out for 125I seeds. With a field size of 20 x 1.5 cm2 and a surface dose of 10 Gy, ovaries at a depth of 10 cm in the central beam will receive a dose of between less than 1 m Gy in electron therapy to around 1 Gy in X-ray therapy (100 KV).

Brachytherapy↗
PubMed1991

[Interstitial Ir-192 afterloading therapy with sequential warm-water hyperthermia].

For selective heating of superficially located or easily accessible tumors interstitial hyperthermia has become an increasing popular method in combination with interstitial radioactive implants. At our institution the hyperthermia treatment is performed utilizing the warm water system KHS-9, which is adapted to our Ir-192 high-dose-rate afterloading device, so that the same hollow needles for the interstitial radiation can be used for the heating procedure. So far, this technique has been applied for the treatment of primary and carcinomas, gynecological recurrences, and metastases of malignant melanomas after preceding in vitro measurements of temperature distribution. As a result both, in vitro and in vivo investigations showed good homogeneity of the temperature throughout the heated volume. Analysing the temperature data of in vivo measurements the maximum deviation of temperature was found to be 1.5 degrees C. When using a needle spacing of 8 mm, the temperature required for clinical application (42.5 degrees C) could be maintained in all heat treatments with a preselected water temperature of 46 degrees C to 49.5 degrees C.

Anus Neoplasms↗
PubMed1991

[The status of oncologic patients in radiotherapy--physical and psychological aspects].

UNLABELLED: This study examines the psychological strains experienced by patients undergoing radiotherapy, as well as their somatic complaints and the possible connection between these two aspects. The sample consisted of 87 cancer patients, 64 female, 23 male. We used two standardized clinical instruments, one Zerssen's list of somatic complaints ("Beschwerdeliste" in German) and Zerssen's questionnaire of wellbeing ("Befindlichkeitsskala" in German). These two research instruments were implemented four times: at the beginning, in the middle and at the end of radiation, and three months afterwards. RESULTS: Both the psychological state of well-being and somatic complaints remained at approximately the same level during the whole course of therapy. The state of well-being increased significantly after therapy, which is indicated by the decrease in the number of psychological impairments, whereas the score for somatic complaints remained the same. We observed a general tendency on the part of the patients to play down their situation. Sex differences were not observed. The discussion of the results includes their implication on the doctor-patient relationship.

Adaptation, Psychological↗
PubMed1990

[Sonographic localization of the kidneys for the purpose of radiation treatment of the abdomen: how accurate is this method?].

In 31 patients, the kidneys were located with ultrasonography before urography was carried out. The projection of the medial, lateral, cranial and caudal margins of the kidney were marked on the patient's back with a pellet. On X-ray film, the mean distance between the pellet and margin of the kidney varied from 0.12 to 1.13 cm; nevertheless the standard deviations were high (up to 2.63 cm). In 11 patients, more than one-third of the kidney was located outside the sonographically determined borders; on the left side this happened in 10 patients. We conclude that sonographical localization of the kidneys for protection during irradiation of the abdomen should only be used when other localization procedures cannot be carried out.

Abdomen↗
PubMed1990

[Effect of the stress coping mechanisms of oncologic patients on their physical and psychological state in radiotherapy].

An empiric study was designed to investigate how patients cope with radiotherapy and its secondary effects. Subject of inquiry was the influence of variables such as age, sex and individual strategies of coping with stress on the extent of reported strain. 91 cancer patients (66 female, 25 male) undergoing radiotherapy with different diagnoses but comparable history and duration of disease were interviewed concerning physical complaints and impairment of psychic mood at four times: in the beginning, the middle and the end of a 6-week radiotherapy as well as 3 moths afterwards. Additionally general coping strategies were evaluated in the beginning. Results showed that reported impairment (only within the subgroup: women under 50) correlated significantly (p less than 0.01) with a coping behaviour that could be described as a "retreat and giving up".

Adaptation, Psychological↗
PubMed1990

[Increasing the thermal enhancement ratio by simultaneous application of radiation and hyperthermia--technical possibilities in interstitial application].

Whereas the cytotoxic effect of hyperthermia is independent and without any time relationship with the radiation treatment, the heat induced radiosensitization only appears with simultaneous application of radiation and heat. Although the highest thermal enhancement ratio (TER) can be achieved with simultaneous application this protocol is not used in clinical practise because of technical problems. From a practical point of view the major effect of a non simultaneous application will have to rely on hyperthermic cytotoxicity. A two-zone needle which offers the possibility to conduct radiation and heat simultaneously in order to confine this to a three-dimensional radiation and heat is described.

Brachytherapy↗