Biomedical subjects
L Har-Zahav
Publications and source records attributed to L Har-Zahav.
[Thyroid function in elderly patients with atypical signs and symptoms].
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[The character and function of mononuclear cells in the spleen and peripheral blood in Hodgkin's disease].
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A hypodiploid clone and its duplicate in acute lymphoblastic leukemia.
Examination of the bone marrow of a 63-year-old man who had acute lymphoblastic leukemia revealed a population of cells with 32 chromosomes and another population with 64 chromosomes, the karyotypical exact duplicate of the first clone. The karyotypic evolution was studied and the findings compared with those described in two similar cases previously reported. It is postulated that severe hypodiploidy is associated with reduced capability of cellular survival, promoting a strong tendency for duplication.
[Treatment of precocious puberty with cyproterone].
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Ultrastructural alterations of peripheral blood cells due to Vipera palaestinae snake bite.
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[The role of zinc in growth and development].
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Acute pancreatitis secondary to hypercalcemia. Occurrence in a patient with breast carcinoma.
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[Subacute dissection of the aorta].
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Clinical and ultrastructural observations in primary acquired sideroblastic anemia.
The clinical and laboratory findings in three patients with primary acquired sideroblastic anemia (PASA) are described. The results demonstrate that what seems to be a well defined entity of the large group of sideroblastic anemias, is in itself a heterogeneous subgroup, with differences capable of detection by more extensive studies. Electron microscopic examination of erythroid cell precursors confirmed previously described features such as deposition of large amounts of iron, mainly in the mitochondria. The precipitated serum proteins revealed an increased content of ferritin molecules only in the patients and not in control individuals, suggesting an increased supply of iron to the erythroid precursors. This finding could serve as an additional mechanism for the accumulation of iron in the erythroid precursors, considering also the defect in heme synthesis and increased permeability of the erythroid membrane for iron, described in this condition.