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Biomedical subjects

L Harman

Publications and source records attributed to L Harman.

7 recordsLinked to original sources
PubMed2003

Reversal and convergence in marsupial chromosome evolution.

The karyotypes of marsupial species are characterized by their relatively low number of chromosomes, and their conservation. Most species have diploid numbers lying between the two modes, 2n = 14 and 2n = 22, but the karyotype of Aepyprymnus rufescens is exceptional in containing 2n = 32 chromosomes. Many differences in diploid number between marsupial species can be accounted for by particular fissions and fusions, which are easy to detect because of the low numbers of chromosomes in each karyotype. This should be a system in which it is possible to detect reversals and repeated chromosome rearrangements. We have used chromosome-specific paints derived from A. RUFESCENS to compare the karyotypes of eight marsupial species, representing closely and distantly related taxa, to trace chromosome change during evolution, and especially to detect reversals and convergence. From these and other painting comparisons, we conclude that there have been at least three reversals of fusions by fissions, and at least three fusions or fissions that have occurred independently in different lineages.

Animals↗
PubMed1991

Increasing Medicaid clients' access to care. Church, state, and private providers collaborate.

Medicaid clients often have difficulty obtaining a physician referral and thus seek treatment for nonemergent conditions in hospital emergency rooms. A committee with representatives from Alexian Brothers Health System, Inc., Elk Grove Village, IL, and Catholic Charities of the Archdiocese of Chicago, Rolling Meadows, IL, has collaborated with six other organizations to put an end to this misuse of the healthcare system in Chicago's northwest suburbs. Catholic Charities Physician Referral Service came about as the result of research conducted by the committee which indicated that persons on public aid have limited resources available to secure primary healthcare. The committee also reviewed a United Way needs assessment and a survey of healthcare professionals and community leaders which substantiated that the community needed a referral service. In the past, Medicaid clients often had to make numerous futile telephone calls to locate physicians who would accept them. Through this service, however, Medicaid clients simply call Catholic Charities Physician Referral Service (which has information on participating physicians' specialty, location, and hospital affiliations) and then call the physician to whom they are referred. When physicians join the referral service, they specify the number of Medicaid patients they are willing to treat during the year. Catholic Charities will help the participating physicians secure payment from the Illinois Department of Public Aid for the health services they have provided.

Catholicism↗
PubMed1987

Generation of radical anions of nitrofurantoin, misonidazole, and metronidazole by ascorbate.

Nitrofurantoin, misonidazole, and metronidazole were reduced to their corresponding nitro anion radicals by ascorbate in anaerobic solutions at high pH. The nitrofurantoin anion radical could be detected at neutral pH. In neutral solutions, the nitro anion radicals of misonidazole and metronidazole were too unstable to be observed by electron spin resonance spectroscopy. At neutral pH, solutions containing ascorbate, nitrofurantoin, or misonidazole consumed oxygen. The addition of superoxide dismutase, catalase, or both superoxide dismutase and catalase decreased the rate of oxygen consumption. These results show that nitro anion radicals are formed by reduction with ascorbate, and superoxide anion radical and hydrogen peroxide are produced by reactions of these radicals with oxygen.

Anaerobiosis↗
PubMed1985

Head and neck complications of epidermolysis bullosa.

Epidermolysis bullosa is a rare congenital skin disease which is characterized by easy formation of traumatic skin bullae. The disease is usually detected in early infancy due to the recurrent bullae. Prognosis is dependent on the histological variant which is present. A case of autosomal recessive epidermolysis bullosa is presented, which demonstrates many of the head and neck complications of the disease. Traditional skin care modalities as well as multiple surgical procedures such as skin grafts and the use of amniotic membrane were used without success. Limited natural healing, which was possibly promoted by oral phenytoin, has occurred.

Child, Preschool↗
PubMed1980

Influence of diuretics on complete denture retention: a preliminary report.

Diuretics were suspected of affecting denture retention. A device was constructed to measure changes in retention. Data were obtained from patients both while they were receiving and not receiving diuretics. Significant changes were noted, and the results indicated that patients taking diuretics are likely to have problems with denture retention.

Denture Retention↗
PubMedDate not supplied

Developing clinical decision-making skills in staff nurses; an educational program.

Clinical decision-making (CDM) is central to professional nursing practice. Use of this process enhances the nurse's ability to assess patients, to identify problems, and to plan individualized care. The Nursing Department at the Toronto General Hospital recognized that in order for nurses to effectively plan individualized care for their patients, they first needed help to develop their CDM skills. In response, a hospital-wide educational program was designed and implemented. This article describes the program and highlights the factors found to be crucial to its success. General recommendations are outlined for those who wish to design similar CDM skill-developing programs.

Clinical Competence↗