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Biomedical subjects

L Hartmann

Publications and source records attributed to L Hartmann.

31 records · Page 2Linked to original sources
PubMed1977

[Abdominal manifestations in hereditary acute angioneurotic oedema. Value of study of the complement system (author's transl)].

Four individuals of the same family suffered from a functional deficiency in C1 esterase inhibitor. In three of them, the manifestations of hereditary angioneurotic oedema were abdominal, paroxystic and pseudo-surgical. They were related to the development of visceral or mucosal oedema. The measurement of total complement (and of its fractions) during the acute episode, as well as dynamic complement studies between attacks, represent a simple method for indicating the probable diagnosis. Only estimation of the functional activity of C1 esterase inhibitor provides definite evidence. Familiarity with the clinical and biological characteristics of these acute abdominal episodes makes it possible to avoid repeated, unnecessary operations in these patients. They should be treated medically, under surgical surveillance, since a patient with angioneurotic oedema may have nevertheless a specific lesion, in addition. In addition, the episode may spread at any time, resulting in oedema of the glottis requiring tracheotomy or immediate intubation.

Abdomen, Acute↗
PubMed1977

[Lymphoid cells of the intestinal mucosa with double kappa and lambda specificity in normal man].

The presence of lymphoid cells possessing both kappa and lambda specificities has been observed in the intestinal mucosa of normal subjects. The variability in the number of such cells in different sections of the same sample and in different subjects seems to be a characteristic of this cell population and may reflect the high activity of the immune system in the small intestine.

Fluorescent Antibody Technique↗
PubMed1977

Diagnostic and therapeutic problems associated with hereditary deficiency of the C1 esterase inhibitor.

Six patients in a family with a history of hereditary angioedema reported swelling of the extremities and recurrent abdominal pain occurring spontaneously or after trauma. Attacks of oedema involving the airways, the greatest danger with this disorder, were present only in one case. This autosomal dominant disease is due to deficient activity of the inhibitor of the first component of complement. Low levels of C4, and absence of C1 esterase inhibitor confirm the diagnosis. Two asymptomatic cases with the appropriate biochemical abnormality are reported in this study. For short term prophylaxis of attacks (before surgery expecially), fresh frozen plasma is used, or better still, C1 esterase inhibitor. For long term prophylaxis of attacks antifibrinolytic and hormonal drugs are used: in two cases, the authors obtained good results with methyltestosterone after failure of tranexamic acid.

Adult↗
PubMed1977

An investigation of the complement system in patients with periodic disease (results from 29 cases).

The complement system was investigated in 29 patients suffering from authentic periodic disease. A statistically significant increase in C4, also in total complement and C3 could be demonstrated. It is possible that the increase in C4 was due to the macrophages which are always present in the infiltrates of periodic disease. This biological observation is of clear practical importance for the diagnosis of the condition both before and after colchicine therapy.

Complement C1 Inactivator Proteins↗
PubMed1977

Immunochemical study on serum proteins in systemic sclerosis.

Forty one patients with systemic sclerosis were studied after separation into three groups according to Barnett's classification. A multi-dimensional statistical analysis eight serum proteins revealed a difference between control patients and patients with type I and type II scleroderma. Type I scleroderma was characterised by a rise in alpha 2 macroglobulin and in the C4 fraction of complement, whilst in type II scleroderma all the proteins studied were raised, with the exception of CO complement, which was normal, and transferrin which was markedly decreased.

Blood Proteins↗
PubMed1977

Lymphoid cells of the normal man intestinal mucosa possessing both kappa and lambda light chain specifities.

The presence of lymphoid cells possessing both kappa and lambda specificities has been observed in the intestinal mucosa of normal subjects. The variability in the number of such cells in different sections of the same sample and in different subjects seems to be a characteristic of this cell population and may reflect the high activity of the immune system in the gut.

Antibody-Producing Cells↗
PubMed1976

[Abdominal manifestations of hereditary angioneurotic edema. Importance of the exploration of the complement system (apropos of 29 families)].

Abdominal manifestations are almost constantly present (85% of cases) in the current form of hereditary Quincke's disease. In some cases, these abdominal manifestations occur even when cutaneomucosal edema is not present which leads to unwarranted often repeated and sometimes dangerous surgery. Apart from a story of heredity diagnosis of such troubles is possible, provided the total complement has been assayed to note its sharp fall. It can be subsequently explained by a functional defect of the C1 esterase inhibitor or alpha2-neuraminoglycoprotein.

Adolescent↗
PubMed1976

[A two-step determination of plasma total cholesterol and free cholesterol by gas-liquid chromatography. Suggestion for a reference method (author's transl)].

A technique for the determination of free and esterified plasma cholesterol by gas-liquid chromatography is proposed as a reference method. After a critical examination of all the stages to prove its validity, the method is compared to the usual techniques. Such a comparison confirms that colorimetric methods are more accurate after a lipidic extraction and with a purification step by liquid-solid chromatography.

Cholesterol↗
PubMed1976

Bidimensional immunoelectrophoresis in three stages (semi micromethod).

A three stage bidimensional immunoelectrophoresis enables a single protein to be identified in a complex rocket pattern. This identification is due to evidence of a complete reaction of identity between the antigen-antibody precipitation lines obtained in two gels.

Blood Protein Electrophoresis↗
PubMed1975

Distinction between hereditary and acquired angioneurotic oedema according to the complement system.

It is often impossible to make a clinical distinction between acquired and hereditary acute angioneurotic oedema. Investigation of the complement system is indispensable for this diagnosis to be established. The value of total complement and C4 and C2 are lowered in the sera in the hereditary form (44 cases) and normal in the acquired type (68 cases). The use of tests for the activation of C1 esterase "in vitro" is useful to distinguish these two types of oedema as has been demonstrated by the formal measurement of C1 esterase inhibitor.

Angioedema↗
PubMed1975

[Investigations of the influence of pH on the oxidative degradation of glucose by E. coli (biochemical glucose demand) (author's transl)].

The oxidative degradation of glucose by E. coli was studied in the Warburg manometer. The pH of the medium was established in these studies at values between 5.5 and 8.0. Analysis of the reaction kinetics by plotting time/consumption curves shows that three consecutive reactions can be distinguished as the substrate is eliminated from the medium: An adaptation phase which is generally relatively brief is followed by two reactions, of which the first proceeds more rapidly or more slowly than reaction 3, depending on pH. The important feature in reactions 1 and 2 is that the oxygen demand is evidently independent of the initial concentration of substrate. In spite of these differences, if the reaction is regarded as a whole, there are no relations involving significant dependence on pH of medium. Neither the substrate-specific biochemical oxygen demand nor the reaction time necessary for catabolism show statistically significant dependence within the range of pH examined. It can be assumed therefore that E. coli possesses a regulation mechanism which compensates for unfavourable environmental conditions. The division of substrate catabolism into constituent reactions, combined with a change in concentration of pacemaker enzyme and a "competitive inhibition" may be of significance in this regulations.

Escherichia coli↗
PubMedDate not supplied

Apartheid medicine. Health and human rights in South Africa.

Human rights and health care under apartheid in South Africa were studied. Human rights violations, such as detention without charge or trial, assault and torture in police custody, and restriction orders, have had devastating effects on the health of persons experiencing them. These violations have occurred in the context of a deliberate policy of discriminatory health care favoring the white minority over the black majority. South Africa's medical societies have had mixed responses to the health problems raised by human rights violations and inequities in the health care system. The amelioration of health care for all and prevention of human rights violations depend on ending apartheid and discrimination and greater government attention to these problems.

Delivery of Health Care↗