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Biomedical subjects

L Hashimoto

Publications and source records attributed to L Hashimoto.

27 records · Page 2Linked to original sources
PubMed1989

Histologic findings and prognostic factors in carcinoma of the upper bile duct.

The histopathologic features of 34 resected carcinomas of the upper bile duct were reviewed. Patients with papillary adenocarcinoma showed a 3-year survival rate of 75 percent, which was better than those with poorly differentiated adenocarcinoma with no 2-year survivors. Infiltration to the serosa of the bile duct, lymph node metastasis, and vascular invasion were important prognostic factors, since the survival was better for the patients without than those with these factors. Among patients with papillary adenocarcinoma, none had hepatic infiltration and lymph node metastasis and most had no infiltration to the serosa. Patients with poorly differentiated adenocarcinoma, in contrast, had extensive association of those prognostic factors. Seventy-five percent of the patients with papillary adenocarcinoma and only 22 percent of patients with poorly differentiated adenocarcinoma were considered to have curative resection. These findings suggest that the histologic type strongly influenced the prognosis of the patients with carcinoma of the upper bile duct and can be used for the determination of the extent of this tumor.

Adenocarcinoma↗
PubMed1987

Effects of superselective arterial embolization and chemoembolization on energy charge and total blood flow of the rat liver.

The superselective transcatheter arterial embolization (TAE) and chemoembolization (TAC) of the periphery of the left and median lobes of the rat liver were performed using 1.5 mg of gelatin sponge dissolved in saline solution and mitomycin (MMC) at a dose of 1.6 mg/kg b.wt. The energy charge (EC) of the embolized and chemoembolized lobes decreased after the embolization but was restored 3 h later. The total hepatic blood flow (THBF) was reduced to about one half and required 1 week to be restored to the preembolization levels in both groups. Microscopic centrilobular necrosis and vacuolization were found. The addition of MMC did not produce marked untoward effects. Thus, the normal liver is able to restore its energy pool despite a reduction in the THBF after superselective arterial embolization, and this recovery is not altered even by the use of a high dose of MMC.

Adenine Nucleotides↗
PubMed1987

The significance of activation of reticuloendothelial function on hepatectomy.

The prognosis of patients after massive hepatectomy is poor in certain cases whose hepatic reserve, including reticuloendothelial function, is deteriorated. We administered OK-432 before 70% hepatectomy on rats to activate the reticuloendothelial function and studied its effect on postoperative course. The elevations in plasma endotoxin, GOT and GTP were attenuated, and the deterioration of the complement activity after hepatectomy was greatly improved by OK-432 treatment. The RNA content in the liver was significantly increased by OK-432 administration. These findings suggest that activation of the reticuloendothelial function at the time of massive hepatectomy enhances endotoxin clearance from blood and thereby contributes in lessening the magnitude of hepatic injury, maintaining the serum complement, and improving liver protein synthesis.

Animals↗
PubMed1987

Activation of reticuloendothelial function for prevention of endotoxemia after hepatectomy in cirrhotic patients.

In order to prevent endotoxemia after hepatectomy in cirrhotic patients, we administered OK-432 before and after hepatectomy to activate the reticuloendothelial function and studied its effect on postoperative endotoxemia. In the cirrhotic group without OK-432 administration (7 patients), the value of endotoxin increased significantly after hepatectomy, compared to the cirrhotic group which received OK-432 administration (5 patients) and the non-cirrhotic group (12 patients), and the endotoxin level was still higher than the preoperative value even on the 14th day. On the other hand, the cirrhotic group with OK-432 administration and the non-cirrhotic group showed minimal increases of endotoxin levels at the first day, which returned to the preoperative values at the third day. Base on these findings, it is suggested that activation of the reticuloendothelial function bears substantial significance as one of the therapeutic modalities for prevention of endotoxemia after hepatectomy in cirrhotic patients.

Biological Products↗
PubMed1985

Superselective arterial embolization of the rat liver.

The superselective transcatheter arterial embolization has currently become an accepted treatment of hepatic tumors. We have developed an experimental model for the evaluation of this therapy in the rat liver. Using the retrograde catheterization of the superior pancreaticoduodenal artery, only the peripheral intrahepatic arterial branches and sinusoids of the median and left lobes of the liver were embolized with 1.2 and 1.5 mg of Gelfoam powder. This method resembles the clinical practice because the superselective embolization could be performed adequately and allows the comparative evaluation of the responses of the embolized and non-embolized lobes.

Animals↗
PubMedDate not supplied

Presentation and management of cystic neoplasms of the pancreas.

Pancreatic cystic neoplasms are uncommon, but it is important to differentiate them from pseudocysts and ductal adenocarcinoma. A retrospective review was performed to determine distinguishing characteristics and optimal treatment. In 51 patients operated on between 1981 and 1994 at a referral center, the following cystic neoplasms were found: 20 serous cystadenomas, 10 mucinous cystadenomas, 11 mucinous cystadenocarcinomas, five cases of mucinous ductal ectasia, and five papillary cystic neoplasms. Both mucinous ductal ectasia and papillary cystic neoplasms had distinguishing features when compared to other cystic neoplasms. Mucinous ductal ectasia was seen only in men, presented with typical symptoms, and had distinctive features on endoscopic retrograde cholangiopancreatography. Papillary cystic neoplasms occurred in young women (mean age 31 years) and were larger (mean 10.3 cm). Mucinous tumors were always symptomatic, whereas 55% of serous tumors were asymptomatic (P <0.001). The overall rate of resectability was 80%, and there was one operative death (2%). Intraoperative biopsy was diagnostic in 18 (78%) of 23 cases. An actuarial 5-year survival of 52% was found for resected mucinous cystadenocarcinomas. In conclusion, papillary cystic neoplasms and mucinous ductal ectasia have distinct characteristics that differentiate them from other types of pancreatic cystic tumors. Serous cystadenoma should be considered in asymptomatic patients and these patients should be closely observed. Symptomatic neoplasms should be resected with long-term survival expected for malignant forms. (J Gastrointest Surg 1998;2:504-508.)

Adenocarcinoma, Mucinous↗