Biomedical subjects

L Hejjel

Publications and source records attributed to L Hejjel.

5 recordsLinked to original sources

PubMed2001

Heart rate variability analysis.

The expansion of heart rate variability analysis has been facilitated by the remarkable development of computer sciences and digital signal processing during the last thirty years. The beat-to-beat fluctuation of the heart rate originates from the momentary summing of sympathetic and parasympathetic influences on the sinus node. According to the extensive associations of the autonomic nervous system, several factors affect heart rate and its variability such as posture, respiration frequency, age, gender, physical or mental load, pain, numerous disease conditions, and different drugs. Heart rate variability can be quantitatively measured by time domain and frequency domain methods that are detailed in the paper. Non-linear methods have not spread in the clinical practice yet. Various cardiovascular and other pathologies as well as different forms of mental and physical load are associated with altered heart rate variability offering the possibility of predicting disease outcome and assessing stress.

Autonomic Nervous System↗

PubMed2000

[Molecular, cellular and clinical aspects of myocardial ischemia].

The authors summarize the fundamentals and actualities of the molecular and cellular background of myocardial ischaemia-reperfusion for the clinician. Metabolic changes following acute and chronic ischaemia and the role of free radicals, white blood cells, the endothelium, the heat shock proteins are reviewed. "New ischaemic syndromes" are important intrinsic adaptation mechanisms. Stunning is a transient contractile dysfunction following short periods of coronary occlusion in spite of restored perfusion. Hibernating myocardium is resulted after progressive chronic ischaemia including reversible contractile dysfunction, reduced metabolism and cellular dedifferentiation. Preconditioning means concomitant development of a protected state against lethal ischaemia after mild noxious stimuli. Several strategies are considered for myocardial cytoprotection based on the complex physiopathology of ischaemia-induced injury.

Apoptosis↗

PubMed2000

Fatal mediastinitis after routine laparoscopic cholecystectomy.

Laparoscopic cholecystectomy is now considered a routine operation with a low complication rate. In this case study, the authors present a laparoscopic cholecystectomy patient who died of masked mediastinitis and concomitant septicemia caused by an unrecognized esophageal perforation after difficult intubation. The authors call attention to the need for early detection of perforating mediastinitis to prevent a lethal outcome from this infrequent but life-threatening condition.

Brain Edema↗

PubMed1999

Laparoscopic gastric surgery. Early experiences.

In the Department of General Surgery the authors performed 12 elective laparoscopic gastric operations for gastric pathologies. The indications for the procedures were recurrent or therapy resistant and complicated peptic ulcer in 9 cases, benign gastric tumors in 2 cases and early gastric cancer in 1 case. Operative procedures were the next: posterior truncal vagotomy with anterior lesser curve seromyotomy (5 patients), total truncal vagotomy with gastrojejunostomy (2 patients), total truncal vagotomy with pyloroplasty (1 patient), total truncal vagotomy with antrectomy and Billroth-II reconstruction (1 patient), resection of benign gastric tumor by the transgastric approach (1 patient), Billroth-II resection for benign gastric tumor (1 patient), wedge resection of gastric wall for early gastric cancer (1 patient). Intraoperative gastroscopy was used for location of the lesion in 4 of 12 cases. Apart from delayed gastric emptying (2 cases), patients recovered without any problem. The mean hospital stay was 5.7 days. Early experiences with laparoscopic gastric surgery has shown that there are certain important advantages to the approaches. They hold the promise of less pain, less immobility, quicker alimentation, shorter hospitalization, less wound and respiratory complications and an earlier return to normal activities.

Anastomosis, Surgical↗

PubMed1997

[Alternatives to heart transplantation].

This paper is about the alternatives of curing the drug-refractory heart failure with the exception of cardiac transplantation. It includes even the newest methods mostly being in the phase of animal experiment in the meantime. The authors give a review on the different possibilities of skeletal muscle autotransplantation for cardiac support, such as cardiomyoplasty which has already been done in Hungary too, externally powered mechanical devices for long-term support, molecular and cellular cardiomyoplasty. The partial ventriculectomy and transmyocardial laser revascularization are mentioned as well. Although, most part of the enumerated procedures is not available in Hungary at this time, they are expected to enter the arsenal of medicine in the future.

Assisted Circulation↗