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Biomedical subjects

L Hellgren

Publications and source records attributed to L Hellgren.

At least 19 recordsLinked to original sources
PubMed1994

Children with deficits in attention, motor control and perception (DAMP) almost grown up: psychiatric and personality disorders at age 16 years.

Fifty-six cases with childhood onset deficits in attention, motor control and perception (DAMP) were followed-up at age 16 years and compared with 45 children without DAMP. Both groups had originally been recruited from the general population at the age of 6 years. Psychiatric disorders (affective disorders in particular) were more common in the DAMP group. Personality disorders were common in both groups, but the DAMP group much more often had a combination of several different personality disorders. The reasons for the discrepancies between teenagers with and without a prior history of DAMP are discussed.

Adolescent↗
PubMed1993

Psychotic disorders diagnosed in adolescence. Outcome at age 30 years.

Fifty-five cases who had been diagnosed in adolescence as suffering from a psychotic condition while attending a child or adult psychiatric clinic were compared with age-, sex- and school-matched cases with respect to various outcome measures at age 30 years. Overall, the outcome for young people who need psychiatric care for psychotic conditions in adolescence appears to be gloomy with respect to psychosocial adjustment. There were clear differences in outcome depending on specific psychosis diagnosis category at the time of original diagnosis. Females tended to have better outcome than males, but differences were small and not conclusive in this respect.

Adolescent↗
PubMed1993

Children with deficits in attention, motor control and perception (DAMP) almost grown up: general health at 16 years.

One hundred and one children (56 with and 45 without deficits in attention, motor control and perception (DAMP)), originally diagnosed at six or seven years of age and belonging to a representative cohort of children from the general population were followed up at 16 and 17 years of age. There was a significant excess of substance abuse, fractures and other accidents in the DAMP group than among controls, in addition to more motor co-ordination problems, clumsiness, and height and weight problems. Mean complex visual reaction time was significantly longer in the DAMP group, accounted for by the number of boys in the group. It appears that 10-year outcome for children who had attention problems and clumsiness during the preschool period is considerably poorer than for those who did not have such problems.

Adolescent↗
PubMed1989

Chromosome findings in twins with early-onset autistic disorder.

In a twin study of autistic disorder, chromosome analyses were carried out in nine pairs of monozygotic (MZ) twins, two pairs of dizygotic (DZ) twins, one set of MZ triplets, one single twin from a MZ pair, and seven single twins from DZ pairs. All but one of the MZ sets were concordant for autistic disorder; all DZ pairs were discordant. Fragile X(q)(27.3) was found in one pair of MZ twins and in MZ triplets, i.e., in 9% of the population with autistic disorder. A marker chromosome of unknown origin was detected in a male twin with autistic disorder from a discordant DZ pair.

Autistic Disorder↗
PubMed1989

Biochemical and biological profile of a new enzyme preparation from Antarctic krill (E. superba) suitable for debridement of ulcerative lesions.

A protease extract from Antarctic krill (E. superba) intended as a new enzymatic debrider for necrotic ulcers has been characterized by sodium dodecyl sulphate polyacrylamide gradient gel electrophoresis and fast protein liquid chromatography. The predominant enzymes in the preparation represent trypsin-like activity associated with three serine proteinases. In addition two carboxypeptidases A and B are present as cooperative enzymes for a more complete breakdown of complex proteinaceous substrates. Biological studies on a well-defined substrate (fibrin) originating from leg ulcers, demonstrated more effective degradation by krill enzymes than bovine trypsin, a common component in marketed enzymatic debriders. These findings support previously in vitro/in vivo studies in an animal model (rat) using excised rat skin as "necrotic" tissue.

Animals↗
PubMed1989

A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden.

The Nordic countries were screened for the occurrence of cases of autism with a same-sexed twin under age 25 years. Twenty-one pairs (11 monozygotic and 10 dizygotic) of twins and one set of identical triplets were found and extensively examined. The concordance for autism by pair was 91% in the monoygotic and 0% in the dizygotic pairs. The corresponding concordances for cognitive disorder were 91% and 30%, respectively. In most of the pairs discordant for autism, the autistic twin had more perinatal stress. The results lend support for the notion that autism sometimes has a hereditary component and that perinatal stress is involved in some cases.

Adolescent↗
PubMed1986

Proteases of Antarctic krill--a new system for effective enzymatic debridement of necrotic ulcerations.

The Antarctic krill (Euphausia superba) possesses an "over-dimensioned' digestive system, which is of vital importance for the survival of this euphaucean shrimp in the extreme marine environment. The isolated enzymes contain a well-balanced mixture of both endo- and exopeptidases, assuring fast and complete breakdown of proteinaceous material. These unique properties have now been shown to be extremely valuable for the effective removal of necrotic debris, fibrin or blood crusts in vitro. Therefore the krill enzymes should be considered as an important resource in the future management of necrotic wounds.

Animals↗
PubMed1986

Teenage psychoses--epidemiology, classification and reduced optimality in the pre-, peri- and neonatal periods.

This is a population-based survey from Göteborg, Sweden, of all youngsters treated as in-patients for operationally defined 'psychotic disorders' during their teens. It was shown that 0.54% of all teenagers in Göteborg had been treated for such disorders at least once during the 13- to 19-year-old age period. Boys and girls were about equally affected, but schizophreniform disorders tended to be much more common among the boys and affective disorders more common among the girls. Child psychiatric services had been consulted much less frequently than adult ones, in spite of the many developmental aspects of the psychotic disorders. Scores for reduced optimality in the pre- and perinatal periods were marginally, though significantly, more common in the psychosis groups than in an age-, sex- and maternity clinic-matched control group.

Adolescent↗
PubMed1983

Cleansing properties of stabilized trypsin and streptokinase-streptodornase in necrotic leg ulcers.

The cleansing effects on pus and debris of streptokinase-streptodornase and of stabilized crystalline trypsin were compared in 40 patients (12 males, 28 females) with necrotic varicose or arteriosclerotic leg ulcers. Both preparations produced significant partial or total cleansing of the ulcers of necrotic material, and both enhanced the granulation and epithelialization of most of the ulcers. Streptokinase-streptodornase was significantly more effective in removing freshly formed damp and smearing pus and debris. Neither preparation prevented the formation of or removed very deep adherent necrotic areas, especially in arteriosclerotic leg ulcers. Trypsin caused significantly more pain than streptokinase-streptodornase during the treatment period and on changing dressings. Both enzymes indirectly reduced the bacterial flora of the ulcers, probably by removal of necrotic wet material.

Aged↗