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Biomedical subjects

L Hendel

Publications and source records attributed to L Hendel.

36 records · Page 2Linked to original sources
PubMed1986

Long-term ranitidine in progressive systemic sclerosis (scleroderma) with gastroesophageal reflux.

Eighteen patients with progressive systemic sclerosis and symptomatic gastroesophageal reflux were studied for 20 weeks. All patients were initially treated with ranitidine for a 6-week period. From the 7th week the patients were randomized to further treatment with either ranitidine or placebo. Heartburn and dysphagia, the endoscopic appearance of the esophageal mucosa, the esophageal motility, and gastroesophageal reflux were assessed during the study. The efficacy of ranitidine was maintained during the 20-week period. A shift to placebo was recognized by the patients almost immediately and caused heartburn and esophageal mucosal inflammation to increase significantly.

Adult↗
PubMed1986

Bioavailability of D-penicillamine in a patient with gastrointestinal progressive systemic sclerosis.

D-penicillamine pharmacokinetics were studied in a patient with gastrointestinal progressive systemic sclerosis possibly complicated by malabsorption. D-penicillamine bioavailability was examined after oral, duodenal, intravenous and rectal administration. No D-penicillamine was detectable in plasma after administration to the gastrointestinal tract. The pharmacokinetics after intravenous administration agreed closely with the corresponding situation in healthy volunteers.

Administration, Oral↗
PubMed1986

Collagen components in the duodenal and rectal mucosa in progressive systemic sclerosis and other diseases.

Small intestinal mucosa from 14 patients suffering from progressive systemic sclerosis and 22 patients with various other diseases was analysed for collagen components. There was no significant difference in the concentration of hydroxyproline, hydroxylysine and proline between the two groups. Rectal mucosa from 11 progressive systemic sclerosis patients, 5 patients with ulcerative colitis and 7 patients with various other diseases was analysed for collagen components. No significant difference was demonstrated in the concentration of hydroxyproline, hydroxylysine and proline between progressive systemic sclerosis patients and patients with various other diseases, but in patients with ulcerative colitis the concentration of hydroxyproline, hydroxylysine and proline were found to be significantly lower than in the two other groups.

Adolescent↗
PubMed1984

Collagen in the esophageal mucosa of patients with progressive systemic sclerosis (PSS).

Eighteen consecutive patients with an established diagnosis of Progressive Systemic Sclerosis (PSS) underwent different investigative procedures to determine possible esophageal involvement. Esophageal sclerosis was demonstrated by X-ray and manometry in 13 patients. In all patients endoscopic biopsies of esophageal mucosa were obtained. In all biopsies the concentrations of hydroxyproline, hydroxylysine and proline were determined. Patients suffering from PSS involving the esophagus were found to have a significantly higher concentration of collagen specific amino acids (hydroxyproline and hydroxylysine) in the esophageal mucosa (endoscopic obtainable biopsies) than patients with PSS not affecting the esophagus.

Adult↗
PubMed1983

Treatment of gastroduodenal ulcers with cimetidine in combination with low-dose propantheline.

Fifty-eight adult outpatients with endoscopically verified gastric, prepyloric or duodenal ulcers completed a double-blind trial of treatment with either cimetidine, 1 g daily, plus propantheline, 45 mg daily (group A) or cimetidine, 1 g daily, plus placebo (group B). After neither three nor six weeks of treatment was there any significant difference between the two groups with regard to ulcer healing or symptomatic relief. The ulcers of 22 (79%) of the 28 patients in group A and 25 (83%) of the 30 patients in group B were healed after six weeks, and 93% of the patients in both groups became painfree. We were thus not able to show any advantage in combining cimetidine treatment for ulcer healing with low-dose propantheline. In a small open trial the patients with healed ulcers received prophylactic treatment for 12 months with 1) cimetidine 800 mg daily, 2) cimetidine 400 mg at bedtime plus propantheline 45 mg daily or 3) propantheline 90 mg daily. No significant differences were found between the ulcer recurrence rates, but it cannot be excluded that a larger number of patients in each group might have yielded real differences.

Adolescent↗
PubMed1981

Effect of Pentagastrin, secretin, and cholecystokinin on gastric secretion of pepsin in man.

In eight volunteers the effect of pentagastrin (0.15, 1.0 and 6.0 microgram/kg body weight/h), secretin (0.5 and 1.0 clinical units/kg b.w./h), and cholecystokinin (CCK) (0.5 and 1.0 Ivy dog units/kg b.w./h) on the gastric secretion of pepsin was investigated to ascertain whether interaction occurred. A high intraindividual variation was found, and also a significant washout of pepsin in the initial period after stimulation. Pepsin secretion was stimulated after pentagastrin (50% above basal level) and even more after secretin (75%-200% above basal level), whereas no stimulation but a tendency for depression was seen after CCK. With the doses of gastrointestinal hormones used in this investigation, no interaction between secretin and CCK on gastric secretion of pepsin in man was demonstrated.

Adult↗
PubMed1976

Combined effect of glucagon and cholecystokinin on gastric secretion in man.

The inhibition of the pentagastrin-stimulated (1 ug/kg b.w./hour) gastric secretion by glucagon (20 ug/kg b.w./hour), cholecystokinin (0.5 IDU/kg b.w./hour), and a combination of these were investigated in 7 volunteers. Glucagon as well as CCK given isolated inhibited the gastric secretion, but no augmentation of inhibition was demonstrated when the hormones were in combination.

Adult↗
PubMed1972

Interaction of calcium and pentagastrin on gastric acid secretion in man.

In a recent report based on the study of a single human subject calcium was found to potentiate the action of pentagastrin on gastric acid secretion. To elucidate this problem gastric acid secretion was studied in five patients during stimulation with pentagastrin and during stimulation with pentagastrin and calcium. No potentiation between the two agents was found.

Adult↗