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Biomedical subjects

L Hens

Publications and source records attributed to L Hens.

At least 37 records · Page 2Linked to original sources
PubMed1981

Cerebral disseminated coagulation. An encephalitis-like syndrome in a boy with dissecting aortic aneurysm.

A boy was suspected of having meningoencephalitis probably of viral origin, although all microbiological, including virological, tests were negative. Postmortem examination revealed a dissecting aortic aneurysm and disseminated intravascular coagulation involving the central nervous system exclusively. The clinical evolution, the age of the patient, and the association of DAA with this cerebral disseminated coagulation is very unusual.

Adolescent↗
PubMed1981

[Shulman's syndrome. Diffuse fasciitis with eosinophilia. A differential diagnosis from polymyositis (author's transl)].

A case of diffuse fasciitis with eosinophilia is reported. The clinical pattern of this disease has some resemblance with polymyositis. In 1974, Shulman described this syndrome as a new entity. The differential diagnosis of those inflammatory and sclerodermatous changes in the perimuscular fascia is considered. An histological, immunological and electrophysiological investigation has been performed. We propose an auto-immunological mechanism in the etiopathogenesis of this syndrome.

Autoantibodies↗
PubMed1980

Telomere and centromere association tendencies in the human male metaphase complement.

"Generalized distances" between centromeres and between telomeres were statistically analyzed (chi 2 tests) in 100 trypsin-banded metaphase figures derived from normal males. Analysis of association tendencies on the first column of obtained c-c, p-p, q-p, and p-q histograms showed significant heterochromatin attraction not only between nonacrocentrics and acrocentrics but also between two nonacrocentric chromosome pairs (1 and 16). However since not all c-heterochromatin-rich chromosomes were involved in associations (pair 5), and conversely, since chromosomes without an important centromeric heterochromatin block were involved in associations (pairs 8 and 11), it is probable that centromeric heterochromatin is not the only factor responsible for chromosome association. Moreover associations occur not only at the centromeres; in our circle analysis of the binding capacity of the telomeres or centromere of one chromosome pair with the telomeres or the centromeres of all other chromosome pairs, we also found preferential associations for T(4,13), T(9,15), T(11,15), T(13,19), T(15,19), T(17,18), T(17,22), and T(19,20). We therefore suggest that heterochromatin is not the only reason for chromosome association and that telomeres may also play an important part in this process.

Adult↗
PubMed1980

Comparison of acrocentric associations in male and female cells. Relationship to the active nucleolar organizers.

This work deals with a computer-aided study of associations between trypsin-banded acrocentrics in different male and female samples in a total of 900 cells. In female samples, acrocentrics 21 appeared as the most frequently involved in associations, followed by chromosome 13, whereas in male samples cell associations seemed more randomly distributed in the different samples. In addition, investigations in one female subject showed a very high correlation between the frequency with which an acrocentric was found in association and the presence and size of its active rDNA genes as shown by silver staining followed by staining with acridine orange.

Chromosomes, Human, 13-15↗
PubMed1980

Metrizamide enhanced CT in hydrosyringomyelia.

The exact evaluation of a hydrosyringomyelic cyst by metrizamide enhanced CT is reported. After intraventricular injection of metrizamide and overflow of contrast medium in the central canal of the spinal cord, CT scan revealed the exact shape and extension of the cyst from C0 to T7.

Adult↗
PubMed1980

Optokinetic training for central anystagmus. A case report.

A good result was obtained by optokinetic training in a patient with complaints of dizziness and instability, only presenting a central nystagmus without further neurological disturbances. This case illustrates that central vestibular disturbances may occur separately without further neurological context; it emphasizes the importance of a thorough ENG investigation in every case presenting some problems of dizziness and/or instability and it suggests the possibility of curing some central cases by training therapy.

Brain Diseases↗
PubMed1979

Catecholamine secreting tumor of the glomus jugulare.

A case of endocrinologically active glomus jugulare is presented. The localization within the tumor of the catecholamine hyperproduction was demonstrated by selective venous sampling from the vena jugularis externa draining the tumor. The norepinephrine/epinephrine ratio was high and of the same order in blood, urine and cerebrospinal fluid. Bioassay showed high levels of intratumoral norepinephrine and epinephrine. The ways of treatment and their influence on the catecholamines are briefly discussed. In every phaeochromocytoma-like syndrome both the existence of catecholamine hyperproduction and the anatomical site of this hypersecretion have to be precisely documented in order to define the correct treatment to be applied.

Catecholamines↗
PubMed1979

Chromosome distribution studies after inorganic lead exposure.

We studied the chromosome distribution in persons professionally exposed to inorganic lead. The degree of lead exposure was evaluated by biochemical measurements and cytogenetic analysis. The chromosome distribution was analyzed from trypsin banded karyotypes; in particular we studied centromere distances (delta2) and centromere-metaphase-center distances (d2) which were obtained by computer-aided mathematical transformation of the individual metaphase coordinates. Higher concentrations of blood lead and urine delta-ALA and a statistically significant increase in aneuploidy, hypoploidy, and type-B chromosome aberrations revealed appreciable exposure although none of the subjects showed signs of excessive lead absorption. However study of the chromosome distribution showed no major differences with that of the controls indicating that lead acts preferentially (directly or indirectly) on the chromosomes rather than on the spindle apparatus. A dissociation of the acrocentric chromosomes was observed in the lead group when compared with the controls. This is thought to reflect a secondary action of lead on the nucleolar organiser regions.

Adult↗
PubMed1979

Hydrocephalus-dementia-complex in Paget's disease.

The clinical triad of gait disturbances, memory impairment and urinary incontinence is associated with a communicating hydrocephalus in the 'normal pressure hydrocephalus'-syndrome. The authors present a case of H.D.C. (hydrocephalus-dementia-complex) in Paget's disease with an identical syndrome, but with obstructive hydrocephalus, causing a triventricular dilatation. Today, each case of mental deterioration in Paget's disease, should be immediately observed and neurosurgical intervention kept in view. An X-ray of the skull, a CT-scan of the brain and a cisternography are performed as routine procedure. If there are indications of involvement of the basis of the skull, hydrocephalus and/or disturbed pattern of the tracer-migration around the convexities, associated with a certain degree of dementia, impaired gait or urinary incontinence, a ventriculo-subcutaneous drain should be inserted. If clinical improvement follows, a ventriculatrial shunt is indicated. The post-operative clinical outcome seems to be dependent on some clinical and technical factors. The most eventful outcome is observed in cases where the clinial triad, described in patients with a classical 'normal pressure hydrocephalus'-syndrome, is associated with an obstructive hydrocephalus, due to a stenosis of the Sylvian aqueduct.

Cerebrospinal Fluid Shunts↗
PubMed1978

Chromosome distribution studies in phenyl mercury acetate exposed subjects and in age-related controls.

Peripheral blood lymphocytes of phenyl mercury acetate exposed persons and a control population of the same age were cultured for 48 h. In both populations 100 metaphases were trypsin-banded and caryotyped. The relative position of the metaphase chromosomes was studied by means of centromere--centromere distances (delta2) and centromere--metaphase centre distances (d2) obtained by computer-aided mathematical transformation of the individual metaphase coordinates. By comparing both investigated cell populations we mainly observed that the chromosome combinations which statistically differ in mercury-exposed workers from the controls show an increase of centromere-centromere distances after mercury exposure. From the data we may suggest that phenyl mercury acetate influences at first the position of particular chromosomes; especially D-group chromosomes which are involved in nucleolus organisation. This may be due to a greater density of SH-wearing molecules in that region or to a possible inhibition of specific enzymes regulating the nucleolar activity. The exposure level is however too low to allow definite conclusions in this respect.

Adult↗
PubMed1977

Non-random association of trypsin-banded human acrocentric chromosomes.

This paper deals with a computer-aided study of the associations between acrocentric chromosomes as well as between those other chromosomes which in our investigations were revealed to be significantly closer to each other than random. The chromosome pairs were identified by a trypsin-banding technique. The method used has been elaborated previously with the specific aim of determining associations in a manner that avoids all subjective criteria. The tendency for association between homologous chromosomes is in decreasing order: 21 and 13 greater than 1 greater than 14, 18 and 19 greater than 17. Among the nonhomologous acrocentric chromosomes the significant tendencies for associations are between D-D: 13-14 greater than 13-15 greater than 14-15; between D-G: 13-21 greater than 14-21 greater than 13-22 greater than 15-22. The implication of the different tendencies to associate are dicussed in terms of aetiology of numerical and structural chromosome abnormalities.

Adult↗
PubMed1977

Vascularization and angioarchitecture of the human pes hippocampi.

After studying the vascularization and the angioarchitecture of the pes hippocampi by means of selective arteriograms, the authors suggest a number of modifications to the classical concepts of arteriolar penetration into this area. Their most striking finding was the typical stratification of the paraventricular area as compared with the gyrus dentatus which is more monomorphically vascularized. The stratum granulosum appeared not to represent a vascular barrier between these two zones. The authors emphasize the remarkable correlation between the fibrillar and cytological construction of the various layers on one hand and their angioarchitectural characteristics on the other.

Cerebral Angiography↗
PubMed1977

Stability of centromere-center distances in normal human metaphases.

Centromere-center distances were analyzed in 50 normal female and 100 normal male metaphases. Compared with the random distribution of all chromosomes, chromosome pair 6 had a significantly different distribution in both female and male metaphases. Moreover, a significant peripheral location of chromosome pairs 4 and 5 and a significant central location of chromosome pairs 13, 15, 21, and 22 were found in male metaphases. But no specific peripheral location could be assigned to the X or Y chromosomes. No inter- nor intraindividual differences or sex-dependent variation in centromere-center distances were observed. Variance analyses demonstrated consistent centromere-center distances in normal human metaphases obtained from individuals of the same age. The constancy of these chromosome distributions may correlate with chromosome duplication pattern, chromosome length, and chromosome structure.

Adult↗
PubMed1976

Chromosome distribution in a23 Chinese hamster fibroblasts.

This study deals with a systematic chromosome position analysis of 116 anti-mitotic and hypotonic treated a23 chinese hamster cells. No chromosome or pair of chromosomes was found to be located nearer the center or the periphery of the metaphase plate than would be expected by the reference distribution. The homologous chromosomes of pair 2 lie nearer to each other but they do not form a specific angle. The same relative position was shown for the chromosome groups 1-2, 1-E1 and 2-E5 (E standing for an extra chromosome). On the other hand the chromosomes of the combinations X-7, X-8, 7-8, 8-11 and X-E2 were lying further from each other, while chromosomes 10-E1 had a greater mean angle. The non random distribution of the chromosomes 1 and 2 may be interpreted as function of their possibly more frequent participation in the organization of nucleoli. -- To obtain more information about the influence of preparation techniques on the alteration of the chromosome position in metaphase plates, this study deals with some overall considerations about chromosome position. It is shown that in a23 cells the smaller chromosomes do not tend to lie nearer the metaphase plate center (as it happens in human cells). Also a significant correlation between the chromosome position with respect to the metaphase plate center and the mean interchromosomal distances was not found in this type of cells.

Cell Line↗
PubMed1975

Relative position of trypsin banded homologous chromosomes in human (female) metaphase figures.

"Generalized distances" between centromeres were statistically analyzed (chi2 test) on 50 normal female trypsin-banded metaphase figures. This study revealed that the homologous chromosomes of the pairs 13, 17, 14, and 21 lie closer together than would be expected by a reference distribution, and this in a statistically significant way. The same relative position was demonstrated for the chromosome groups 13-14, 13-21, 14-21, 15-22, and 14-22. Evidences were collected that also showed that homologous chromosomes of the pairs 1, 19, and 20 and the chromosome groups 15-21, 13-15, and 18-20 tend to lie closer together. Giving a functional interpretation to the phenomenon of non-random distribution of chromosomes in metaphase figures, it may be suggested that the chromosomes 13, 14, and 21 are involved in the organization of the human nucleolar organizers, more frequently than the other D- and G-group chromosomes.

Cell Nucleus↗