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L Hightower

Publications and source records attributed to L Hightower.

5 recordsLinked to original sources
PubMed1987

Antispermatogenic effects of cyclophosphamide in the Syrian hamster.

Cyclophosphamide is an alkylating antineoplastic drug and has been shown to impair spermatogenesis after chronic exposures. The purpose of this investigation was to determine the effect of cyclophosphamide on sperm production in hamsters following subacute intraperitoneal (ip) exposures. The Syrian hamster, Mesocricetus auratus, aged 10-11 wk, received single daily ip doses for 4 d ranging from 10 to 250 mg cyclophosphamide/kg body weight. Control hamsters received an equivalent volume of phosphate-buffered saline solution. Testis weight, caudal sperm number, and sperm morphology were monitored for 12 wk. Cyclophosphamide failed to induce sperm abnormalities. Testis weight and sperm count were slightly suppressed at wk 1 and 4 before returning to normal at wk 12. This study showed that subacute doses of cyclophosphamide in hamsters did not significantly affect the sperm production as previously reported in other animals.

Animals↗
PubMedDate not supplied

Osteoporosis: pediatric disease with geriatric consequences.

Osteoporosis affects 28 million Americans. The National Osteoporosis Foundation estimates this number will increase to 41 million by 2015. Ninety percent of bone growth occurs between the ages of 10 and 20. Present lifestyles of adolescents leave them predisposed to osteoporosis because they are producing lower peak bone mass. If teenagers can be taught to build their bones as strong as possible with diet and exercise, many cases of this disease may be prevented. This article outlines a method of teaching teens about osteoporosis that has been used with 250 junior high and high school students with favorable results.

Adolescent↗