Biomedical subjects
L Honoré
Publications and source records attributed to L Honoré.
Holoprosencephalic synophthalmia (cyclopia) in an 8 week fetus.
Histopathological examination of an 8-week-old human cyclopic fetus revealed holoprosencephaly, synophthalmia, and malformed midfacial features. The telencephalon was undivided and projected a single median optic stalk partially subdivided into optic vesicles contained in a single orbit. Aberrant midfacial ossification underlay arrhinia and uncleft lips and palate. Maxillary anodontia and mandibular hypodontia prevailed. Postcranial normality was disturbed by pedal postaxial hexadactyly, suggesting trisomy 13. The exceptionally young age of the specimen distinguishes its detailed analysis from the majority of older cyclopic specimens previously reported.
Drug effects on the EEG of various species of laboratory animals.
The analysis of the results obtained in different tests--sleep studies, cortical and hippocampal EEG activity, PGO-R spikes--in rats or in cats allows the characterization of different classes of drugs and to establish the relative efficacy of psychoactive drugs in these models. Moreover, the sequential spectral analysis of cortical EEG recordings in curarized rats allows the assessment of EEG modifications, of the presence of hypersynchronized rhythms, of the induction and duration of drug action, of topographic drug effects and interactions between different agents. Thus, the use of EEG techniques in various animal species allows a better classification and definition of the central action of drugs.
Re: multiple endocrine adenomatosis: in support of the common origin theories.
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